Hypertrophic cardiomyopathy trials in United States

In United States 21 Also abroad 88

21 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic Cardiomyopathy
Where
Burlington, Manhasset, Plano, Rock Hill
Age
18 years to 85 years
People
210
Run by
Braveheart Bio, Inc.
See details and how to joinNCT07755904 · EU 2026-526007-30-00
No phaseNot yet taking people in United States
NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices
Where
Atlanta, Boston, Charlottesville, Roanoke, Roslyn, The Bronx, Washington D.C., York
Age
21 years to 100 years
People
200
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT07806149
Phase 1Taking people
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HTX-001
Where
Boston, Cincinnati, Kansas City
Age
18 years to 70 years
People
10
Run by
Haya Therapeutics, Inc.
See details and how to joinNCT07867288
Phase 2Taking people
A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy
Where
Atlanta, Baltimore, Boston, Burlington, Charlotte, Charlottesville, Chicago, Grand Rapids, Houston, La Jolla, Los Angeles, Miami, Milwaukee, New York, Oak Lawn, Philadelphia, Plano, Portland, Richmond, Rochester, Salt Lake City, San Francisco, St Louis, Washington D.C.
Age
18 years and over
People
165 worldwide
Run by
Imbria Pharmaceuticals, Inc.
See details and how to joinNCT07023614
No phaseTaking people
HCMR Re-Imaging Study
Where
Ann Arbor, Boston, Charlottesville, Cleveland, Medford, Rochester
Age
18 years to 65 years
People
314 worldwide
Run by
Christopher Kramer
See details and how to joinNCT07054073
Phase 2/3Enrolling by invitation
Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM
Where
Anchorage, Ann Arbor, Atlanta, Birmingham, Boston, Burlington, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Dallas, Detroit, Durham, Falls Church, Fayetteville, Fort Lauderdale, Greenville, Honolulu, Houston, Iowa City, Kansas City, La Jolla, Los Angeles, Manhasset, Milwaukee, Minneapolis, Morgantown, Morristown, Murray, Nashville, New Haven, New York, Philadelphia, Phoenix, Pittsburgh, Portland, Rochester, Salt Lake City, San Francisco, Seattle, Tulsa, Valhalla, Washington D.C.
Age
18 years to 85 years
People
900 worldwide
Run by
Cytokinetics
See details and how to joinNCT04848506 · EU 2023-508963-58-00
Phase 2Taking people
A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease
Where
Boston, La Jolla, Philadelphia
Age
8 years and over
People
18 worldwide
Run by
Rocket Pharmaceuticals Inc.
See details and how to joinNCT06092034
Phase 2Taking people
Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy
Where
Tampa
Age
6 years and over
People
26
Run by
Lexeo Therapeutics
See details and how to joinNCT07721025 · EU 2025-524970-40-00
No phaseTaking people
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Where
Anchorage, Aurora, Baltimore, Bethlehem, Boston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Cooperstown, Dallas, Durham, Grand Rapids, Greenville, Hackensack, Hartford, Honolulu, Houston, Indianapolis, Iowa City, Jacksonville, Kansas City, La Jolla, Lancaster, Little Rock, Los Angeles, Madison, Milwaukee, Minneapolis, Morgantown, Morristown, Nashville, New York, Omaha, Palo Alto, Pittsburgh, Plano, Richmond, Roanoke, Roslyn, San Francisco, Seattle, St Louis, Temple, Tucson, Tupelo, Valhalla, Washington D.C., West Bloomfield, Wilkes-Barre
Age
18 years and over
People
1,700 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT05489705
No phaseTaking people
Study of the Progression of Chronic Cardiovascular Conditions
Where
Chicago
Age
18 years and over
People
5,000
Run by
Prolaio
See details and how to joinNCT07420907
No phaseTaking people
Cardiovascular Multimodality Imaging Study
Where
The Bronx
Age
18 years and over
People
10,000
Run by
Montefiore Medical Center
See details and how to joinNCT06610019
No phaseTaking people
Pediatric Cardiomyopathy Mutation Analysis
Where
Indianapolis
People
300
Run by
Indiana University
See details and how to joinNCT02432092
No phaseTaking people
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Where
Beverly Hills, Boston, Cleveland, New York, Rochester
Age
50 years and over
People
1,663
Run by
Columbia University
See details and how to joinNCT06034405
Phase 4Taking people
Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy
Where
Kansas City, Portland
Age
18 years to 90 years
People
40
Run by
Oregon Health and Science University
See details and how to joinNCT07600177
Phase 1/2Taking people
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Where
Atlanta, Boston, Cincinnati, Cleveland, Houston, La Jolla, Philadelphia, Portland, Rochester, San Francisco
Age
18 years to 75 years
People
30
Run by
Tenaya Therapeutics
See details and how to joinNCT05836259
No phaseEnrolling by invitation
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Where
Baltimore
Age
18 years to 85 years
People
100
Run by
Johns Hopkins University
See details and how to joinNCT02413450
No phaseTaking people
Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
Where
San Francisco
Age
18 years to 80 years
People
70
Run by
University of California, San Francisco
See details and how to joinNCT05818605
No phaseTaking people
Mavacamten Pregnancy Surveillance Program
Where
Wilmington
Age
15 years and over
People
20
Run by
Bristol-Myers Squibb
See details and how to joinNCT05939700
No phaseTaking people
Large Language Models To Improve the Quality of Care of Cardiology Patients
Where
Palo Alto
Age
18 years and over
People
12
Run by
Stanford University
See details and how to joinNCT06935253
No phaseTaking people
Real-world Patient Reported Outcomes Among Patients Treated With Camzyos
Where
Boston
Age
18 years and over
People
118
Run by
Bristol-Myers Squibb
See details and how to joinNCT06551129
No phaseTaking people
Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM
Where
Charlottesville
Age
18 years to 85 years
People
20
Run by
Michael Ayers
See details and how to joinNCT06023186