Lupus (SLE) trials in United States

In United States 100 Also abroad 359

79 of 100 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 3Enrolling by invitation
A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus
Where
Atlanta, Avondale, Beckley, Bellaire, Beverly Hills, Birmingham, Brandon, Canton, Charlotte, Chicago, Colleyville, Denver, Detroit, Gainesville, Glendale, Hagerstown, Hershey, Hopkinsville, Idaho Falls, Jackson, Lake Charles, La Palma, Las Vegas, Manhasset, Miami, New Orleans, New York, Ormond Beach, Phoenix, Plantation, San Leandro, Tampa, Tucson
Age
16 years and over
People
760 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT04976322 · EU 2023-506368-14-00
No phaseTaking people
Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus
Where
Birmingham, Cincinnati, Grand Rapids, New Orleans, Seattle, The Bronx
Age
12 years to 22 years
People
175 worldwide
Run by
Michigan State University
See details and how to joinNCT06232304
Phase 3Taking people
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
Where
Anniston, Austin, Baytown, Birmingham, Brandon, Colleyville, Edinburg, Fontana, Houston, Kansas City, La Jolla, Lake Charles, La Palma, Memphis, Menifee, Miami, New Albany, Oklahoma City, Phoenix, San Leandro, Silver Spring, Spokane, St. Petersburg, Sugar Land, Temecula, Tucson, West Long Branch, Willowbrook
Age
18 years to 70 years
People
245 worldwide
Run by
AstraZeneca
See details and how to joinNCT07430306
Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
Phase 2Taking people
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
Where
Amarillo, Aventura, Beverly Hills, Brandon, Charlotte, Clearwater, Colleyville, Denver, Duncansville, Euless, Fayetteville, Frisco, Grand Blanc, Great Falls, Houston, Jackson, Katy, Lansing, La Palma, Memphis, Mesquite, Middleburg Heights, Oklahoma City, Plantation, San Diego, Tampa, Torrance, Upland, West Hills
Age
18 years to 74 years
People
405 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07409181 · EU 2025-523488-39-00
Phase 3Taking people
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
Where
Ann Arbor, Baltimore, Boca Raton, Boston, Charleston, Charlotte, Chicago, Cleveland, Columbus, Dallas, Fort Lauderdale, Indianapolis, Irvine, Los Angeles, New York, Omaha, Phoenix, Portland, Roanoke, Rochester, San Francisco
Age
5 years to 80 years
People
1,072 worldwide
Run by
AstraZeneca
See details and how to joinNCT07691970
Phase 3Taking people
A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]
Where
Troy
Age
18 years to 76 years
People
404
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07840287 · EU 2026-525294-39-00
Phase 3Taking people
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
Where
Anniston, Aurora, Baltimore, Bellaire, Burbank, Clearwater, Cooper City, Detroit, Grand Blanc, Homestead, Jackson, Lake Charles, La Palma, Lawrenceville, League City, Memphis, Middleburg Heights, New Orleans, Pittsburgh, Plantation, Red Oak, Skokie, Tampa, Westlake Village, Willowbrook
Age
12 years to 100 years
People
550 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06133972 · EU 2023-505929-14-00
Phase 3Taking people
Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)
Where
Orchard Park
Age
18 years to 100 years
People
348 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06711887 · EU 2024-515280-60-00
Phase 4Taking people
Dapagliflozin in Active Lupus Nephritis
Where
Boston
Age
18 years to 70 years
People
33
Run by
Brigham and Women's Hospital
See details and how to joinNCT07323524
Phase 3Taking people
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease
Where
Allen, Atlanta, Cooper City, Corpus Christi, Los Angeles, Miami, Tamarac, Tampa, Thousand Oaks, Troy
Age
18 years to 75 years
People
202 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07332481 · EU 2025-523871-44-00
Phase 3Taking people
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
Where
Auburn Hills, Charlotte, DeBary, Fort Lauderdale, Frisco, Hollywood, Houston, Humble, Indianapolis, Lake Charles, Miami, Pembroke Pines, Smithfield, Tampa, Upland
Age
18 years to 75 years
People
202 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07355218 · EU 2025-524855-30-00
Phase 2Taking people
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
Where
Atlanta, Aurora, Cincinnati, El Paso, Hackensack, Indianapolis, Loma Linda, Philadelphia, Queens, San Francisco, Shreveport
Age
5 years to 17 years
People
40 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT05039619 · EU 2023-505825-15-00
Phase 1/2Taking people
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
Where
Houston
Age
18 years and over
People
47
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06434363
Phase 3Taking people
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Where
Amarillo, Atlanta, Aventura, Beverly Hills, Charlotte, Clearwater, Denver, Fayetteville, Frisco, Hemet, Hialeah, Jackson, Katy, Lake Charles, La Palma, Marietta, Mesquite, Miami, Miami Gardens, Miami Lakes, Middleburg Heights, Mission Viejo, Newark, Oklahoma City, Philadelphia, Plano, Plantation, Red Oak, Roanoke, San Leandro, Sterling Heights, Sugar Land, Tampa, Torrance, Tustin, Upland, Voorhees Township, Willowbrook
Age
18 years to 75 years
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07438496 · EU 2025-523552-31-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Where
Aurora, Avondale, Baton Rouge, Bellaire, Beverly Hills, Brandon, Brooklyn, Chandler, Charlotte, Chicago, Clearwater, Coral Gables, Detroit, El Paso, Fort Worth, Frisco, Gainesville, Gilbert, Glendale, Grapevine, Hollywood, Houston, Iowa City, Jackson, Kansas City, La Jolla, Lake Charles, La Palma, Los Alamitos, Los Angeles, Louisville, Manhasset, Mansfield, Margate, Marietta, Menifee, Mesquite, Miami, Murfreesboro, New Albany, New Orleans, New York, Oklahoma City, Orange, Phoenix, Pittsburgh, Plantation, Rockville, San Leandro, Scottsdale, Searcy, Spokane Valley, Syracuse, Tampa, Willowbrook, Winter Park
Age
16 years and over
People
450 worldwide
Run by
UCB Biopharma SRL
See details and how to joinNCT06617325 · EU 2023-508191-11-00
Phase 1Taking people
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Where
Aurora, Baltimore, Charleston, Charlotte, Chicago, Durham, East Brunswick, Greenville, Iowa City, Jacksonville, Kansas City, Loma Linda, Louisville, New York, Phoenix, Salt Lake City, Valhalla
Age
18 years to 74 years
People
66 worldwide
Run by
Allogene Therapeutics
See details and how to joinNCT07085104
Phase 2Taking people
Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)
Where
Houston, New York, San Antonio, Syracuse
Age
12 years to 65 years
People
35 worldwide
Run by
Autolus Limited
See details and how to joinNCT07053800 · EU 2024-519941-32-00
Phase 4Taking people
Safety of the Herpes Zoster Subunit Vaccine in Lupus
Where
New York, Oklahoma City
Age
18 years to 90 years
People
224
Run by
NYU Langone Health
See details and how to joinNCT05559671
Phase 1Taking people
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
Where
Allen, Birmingham, Fullerton, Mesquite, Plantation, St Louis
Age
18 years to 65 years
People
48 worldwide
Run by
AstraZeneca
See details and how to joinNCT07201558 · EU 2025-522273-10-00
Phase 1Taking people
Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis
Where
Gainesville, Houston, Rochester, San Francisco
Age
18 years to 60 years
People
90 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06975787 · EU 2024-518288-37-00
Phase 1Taking people
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Where
Avondale, Boston, Iowa City, Memphis, New York, Orlando, Plano, Rochester, Salt Lake City, Tucson, Webster
Age
18 years to 70 years
People
24 worldwide
Run by
Cullinan Therapeutics Inc.
See details and how to joinNCT06613360 · EU 2024-518780-36-00
Phase 1Taking people
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Where
Boston, Chapel Hill, Chicago, Iowa City, La Jolla, New Orleans, Portland, Redwood City, St Louis
Age
18 years to 70 years
People
80 worldwide
Run by
CRISPR Therapeutics
See details and how to joinNCT06925542
Phase 1Taking people
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Where
Anniston, Clearwater, Greenacres City, Houston, Jackson, Kissimmee, Miami, Orland Park, Plantation, Red Oak, Tampa, Tustin
Age
18 years to 75 years
People
30 worldwide
Run by
AbbVie
See details and how to joinNCT07607964
Phase 1Taking people
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Where
Anniston, Birmingham, Chapel Hill, Iowa City, La Jolla, Omaha, Sacramento
Age
18 years to 70 years
People
72 worldwide
Run by
AstraZeneca
See details and how to joinNCT06916806 · EU 2024-519015-34-00