Lupus (SLE): open trials in United States

100 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT06875960
A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132
Trial Treatment · Phase 4 · Bristol-Myers Squibb
Farmington · Jackson · New York University School of Medicine, New York · Oklahoma Medical Research Foundation, Oklahoma City
Registry updated 2026-09-09
NCT06659029
Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users
Research · AstraZeneca
Wilmington
Registry updated 2026-09-02
NCT07800871
FT839 in Autoimmune Diseases
Trial Treatment · Phase 1/2 · Fate Therapeutics
Providence Medical Foundation, Fullerton
Registry updated 2026-09-02
NCT05799378
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
Trial Treatment · Phase 3 · NYU Langone Health
Emory University School of Medicine, Atlanta · Hackensack Meridian Health, Hackensack · Penn State MS Hershey Medical Center, Hershey · University of California, Los Angeles, Los Angeles · NYU Langone Health, New York · NYC Health + Hospitals / Bellevue, New York · Hospital for Special Surgery, New York · Columbia University Irving Medical Center/New York Presbyterian, New York · VA NY Harbor Healthcare System, New York · Oklahoma Medical Research Foundation, Oklahoma City · University of California San Diego, San Diego · Montefiore Medical Center-Albert Einstein College of Medicine, The Bronx
Registry updated 2026-08-20
NCT06458075
Intervention to Improve Communication and Medication Adherence in Lupus
Trial Treatment · Duke University
Duke University, Durham
Registry updated 2026-08-17
NCT06977724
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)
Trial Treatment · Phase 1 · AbbVie
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 278239, Avon Park · Clinical Research Of West Florida - Phase I Unit /ID# 275834, Clearwater · Integrative Rheumatology of South Texas - Harlingen /ID# 276458, Harlingen · Life Clinical Trials - Colonial Drive - Margate /ID# 276050, Margate · Private Practice - Dr. Ramesh C. Gupta /ID# 275826, Memphis · Advanced Quality Medical Research /ID# 278462, Orland Park · Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 275836, Tampa
Registry updated 2026-08-10
NCT07180537
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
Trial Treatment · Terry L. Wahls
Univeristy of Iowa, Iowa City
Registry updated 2026-08-10
NCT07611214
PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis
Trial Treatment · Phase 4 · Aurinia Pharmaceuticals Inc.
Western Nephrology & Metabolic Bone Disease, PC, Arvada · Novel Research LLC, Bellaire · Joint and Muscle Research Institute, Charlotte · Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte · Dunes Clinical Research, Dakota Dunes · Liberty Research Center, Dallas · Texas Arthritis Center, El Paso · Integrative Rheumatology of South Texas, Harlingen · Northwest Houston Arthritis Center, Houston · West Tennessee Research Institute, Jackson · Swati Shah MD Rheumatology, LLC, Jacksonville · Kansas City Physician Partners, Kansas City · Vida Clinical Research, Kissimmee · Accurate Clinical Research, Inc, Lake Charles · Purushotham & Akther Kotha MD, Inc, La Mesa · University of Nevada Las Vegas, Las Vegas · Parris and Associates Rheumatology, Lawrenceville · Valerius Medical Group & Research Center of Greater Long Beach, Inc., Los Alamitos · Texas Tech University Health Science Center, Lubbock · Life Clinical Trials, Margate · Buffalo Rheumatology and Medicine, PLLC, Orchard Park · CTR Oakwater, Orlando · Texas Rheumatology Research Institute LLC, Plano · Arthritis and Rheumatism Associates, Rockville · Nephrology Leaders and Associates, PLLC, Van Vleck · Sahni Rheumatology & Therapy, West Long Branch · Rheumatic Disease Associates, Ltd., Willow Grove
Registry updated 2026-08-03
NCT06032923
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Trial Treatment · Phase 1/2 · National Heart, Lung, and Blood Institute (NHLBI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-07-31
NCT07201129
A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment
Trial Treatment · Phase 3 · Viatris Innovation GmbH
Rheumatology Care Center, PLLC, Bellaire · Dolphin Medical Research, Doral · Texas Arthritis Center, El Paso · Northwest Houston Arthritis, Houston · Novel Research LLC, Houston · Alloy Clinical Research LLC, Kissimmee · Allied Biomedical Research Institute, Miami · DH NationalResearchCenters INC, Miami · ProfessionalResearchCenter INC, Miami · SouthCoast Research Center, Miami · San Marcus Research Clinic, Inc., Miami Lakes · Discovery Clinical Trials LLC, San Antonio · Revive Research Institute, LLC, Sterling Heights · Azul Bioresearch Llc, Sugarland
Registry updated 2026-07-30
NCT00756769
Systemic Lupus Erythematosus in Gullah Health
Research · Medical University of South Carolina
Medical University of South Carolina, Charleston
Registry updated 2026-07-28
NCT07729995
BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease
Trial Treatment · Phase 1 · Luminary Therapeutics
Boston Children's Hospital, Boston
Registry updated 2026-07-28
NCT07089121
Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders
Trial Treatment · Phase 1/2 · Cartesian Therapeutics
Cincinnati Children's Hospital Medical Center, Cincinnati · H03- Washington University School of Medicine, St Louis · H01- Children's National Hospital, Washington D.C.
Registry updated 2026-07-27
NCT04833465
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Research · Children's National Research Institute
Children's National Health System, Washington D.C.
Registry updated 2026-07-24
NCT06217107
Wellness & Workforce Solution for Lupus/Lupus Nephritis
Trial Treatment · Morehouse School of Medicine
Morehouse School of Medicine, Atlanta
Registry updated 2026-07-24
NCT07237659
Phase 1a/b Tolerability of NTR-1011 in Healthy Adults and Adult Patients With SLE and RA
Trial Treatment · Phase 1 · Neutrolis
Carewell Arthritis Center, Apple Valley · Attune Health Research Inc, Beverly Hills · Covina Arthritis Clinic, Covina · Novamed, Monterey Park · Southland Arthritis Clinic, Riverside · Southland Arthritis Clinic, Temecula · Foothill Arthritis Clinic, Tujunga
Registry updated 2026-07-20
NCT07115745
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Trial Treatment · Phase 1 · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Brigham and Womens Hospital, Boston · Duke University, Durham
Registry updated 2026-07-14
NCT07138898
Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty
Trial Treatment · Phase 2 · NYU Langone Health
NYU Langone Health, New York
Registry updated 2026-07-09
NCT06527872
Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
Research · GlaxoSmithKline
Baltimore · Charlotte · Columbus · Hixson
Registry updated 2026-07-02
NCT06518668
A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus
Trial Treatment · Phase 1 · Hospital for Special Surgery, New York
Hospital for Special Surgery, New York · Columbia University Irving Medical Center, New York
Registry updated 2026-06-22
NCT06576271
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
Trial Treatment · Phase 1 · GlaxoSmithKline
Aurora · Columbus · Dallas · Las Vegas · Oklahoma City · Scottsdale
Registry updated 2026-06-22
NCT06708845
US Zamto-cel Autoimmune Diseases
Trial Treatment · Phase 1 · Miltenyi Biomedicine GmbH
Froedtert Hospital and the Medical College of Wisconsin, Milwaukee
Registry updated 2026-06-11
NCT06557265
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Trial Treatment · Phase 1/2 · Nkarta, Inc.
Ann Arbor · Atlanta · Chicago · Dallas · Gainesville · Houston · Little Rock · Miami · New Orleans · New York · Plantation · Stony Brook · Summit · Syracuse · Tampa · Tustin · Worcester
Registry updated 2026-06-04
NCT06625671
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE/CLE Participants
Trial Treatment · Phase 1/2 · DualityBio Inc.
US03-0, Clearwater · US04-0, Irving · US06-0, La Palma · US05-0, Orlando · US02-0, San Antonio · US08-0, Syracuse
Registry updated 2026-06-02
NCT06308978
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Trial Treatment · Phase 1 · Fate Therapeutics
Wallace Rheumatic Center, Beverly Hills · MetroHealth, Cleveland · Duke University Health System, Durham · Providence Medical Foundation, Fullerton · University of Florida, Gainesville · University of California, Irvine, Irvine · Children's Hospital Los Angeles Division Of Rheumatology, Los Angeles · University of Louisville, Louisville · Regional One Health, Memphis · Nicklaus Children's Hospital, Miami · University of Minnesota Medical School, Minneapolis · Montefiore Medical Center, New York · University of Oklahoma, Oklahoma City · University of Nebraska Medical Center, Omaha · Jefferson Einstein Hospital Philadelphia, Philadelphia · University of California San Francisco, San Francisco
Registry updated 2026-05-22

All Lupus (SLE) trials and the map

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