Macular degeneration: open trials in United Kingdom

• NCT06847542

  A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

  Trial Treatment · Phase 3 · Hoffmann-La Roche

  Bristol Eye Hospital, Bristol · Gloucestershire Royal Hospital, Gloucester · Leicester Royal Infirmary, Leicester · Moorfields Eye Hospital NHS Foundation Trust, London

  Registry updated 2026-11-06

• NCT06541704

  A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

  Trial Treatment · Phase 3 · Regeneron Pharmaceuticals

  University Hospitals Bristol NHS Foundation Trust, Bristol · Liverpool University Hospitals NHS Foundation Trust-Royal Liverpool University Hospital, St Paul's Eye Unit-Ophthalmology, Liverpool · Moorfields Eye Hospital NHS Foundation Trust, Moorfields Eye Hospital, London · Imperial College Healthcare NHS Trust, London · The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne · York and Scarborough Teaching Hospitals NHS Foundation Trust, York

  Registry updated 2026-11-05

• NCT06635148

  A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

  Trial Treatment · Phase 2/3 · Janssen Research & Development, LLC

  Bristol Eye Hospital, Bristol · Oxford Eye Hospital, Headington · The Retina Clinic London, London · Royal Victoria Infirmary, Newcastle upon Tyne

  Registry updated 2026-11-03

• NCT07007065

  Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

  Trial Treatment · Phase 3 · AbbVie

  Bristol Eye Hospital /ID# 266155, Bristol · Gloucestershire Royal Hospital /ID# 276072, Gloucester · Royal Liverpool University Hospital /ID# 265854, Liverpool · Moorfields Eye Hospital /ID# 267227, London · The Retina Clinic London /ID# 266156, London · The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 267024, Newcastle upon Tyne · Sunderland Royal Hospital /ID# 266664, Sunderland

  Registry updated 2026-10-29

• NCT03683251

  Extension Study for the Port Delivery System With Ranibizumab (Portal)

  Trial Treatment · Phase 3 · Hoffmann-La Roche

  Bristol Eye Hospital, Bristol · Royal Liverpool University Hospital, Liverpool · Moorfields Eye Hospital NHS Foundation Trust, London · Kings College Hospital NHS Foundation Trust, London · Central Middlesex Hospital, London · Royal Victoria Infirmary, Newcastle upon Tyne · Sunderland Eye Infirmary, Sunderland · Royal Wolverhampton hospital, Wolverhampton

  Registry updated 2026-10-27

• NCT07215234

  A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

  Trial Treatment · Phase 1/2 · Sanofi

  London

  Registry updated 2026-10-20

• NCT07064759

  Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

  Trial Treatment · Phase 3 · 4D Molecular Therapeutics

  Bradford Royal Infirmary, Bradford · The Retina Clinic London, London · Sunderland Eye Infirmary, Sunderland

  Registry updated 2026-10-19

• NCT07144137

  A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)

  Research · Complement Therapeutics

  Belfast City Hospital, Belfast · Frimley Park Hospital, Frimley · Gloucestershire Royal Hospital, Gloucester · Moorfields Eye Hospital, London · The Retina Clinic London, London · Central Middlesex Hospital, London · Manchester Royal Eye Hospital, Manchester · University Hospital Southampton, Southampton · Sunderland Eye lnfirmary, Sunderland

  Registry updated 2026-10-16

• NCT07392255

  An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)

  Trial Treatment · Phase 1/2 · Complement Therapeutics

  Gloucestershire Royal Hospital, Gloucester · The Retina Clinic London, London · Moorfields Eye Hospital, London · Sunderland Specialist Eye Hospital, Sunderland

  Registry updated 2026-10-16

• NCT07441642

  A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

  Trial Treatment · Phase 2 · Novartis Pharmaceuticals

  Bristol · London · Newcastle upon Tyne · Southampton

  Registry updated 2026-10-13

• NCT07440225

  A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

  Trial Treatment · Phase 2/3 · EyeBiotech Ltd.

  University Hospitals of Leicester NHS Trust (Site 209), Leicester · South West Retina, Liverpool · London North West University Healthcare NHS Trust (LNWH) (Site 201), London

  Registry updated 2026-10-02

• NCT05481827

  ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study

  Trial Treatment · Phase 2 · Gyroscope Therapeutics Limited

  The Retina Clinic London, London · South Tyneside and Sunderland NHS Foundation Trust - Sunderland Eye Infirmary, Sunderland

  Registry updated 2026-09-28

• NCT07606365

  A Study in Adults With Geographic Atrophy

  Trial Treatment · Phase 2 · Sitala Bio LTD

  University Hospitals of Leicester NHS Trust, Leicester · The Retina Clinic London, London · Royal Victoria Infirmary, Newcastle upon Tyne · Southampton General Hospital, Southampton

  Registry updated 2026-09-21

• NCT04663750

  Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).

  Trial Treatment · Phase 3 · King's College Hospital NHS Trust

  Belfast Health and Social Care Trust, Belfast · University Hospitals Sussex NHS Trust, Brighton · Bristol Eye Hospital, Bristol · Kent & Canterbury Hospital (East Kent University), Canterbury · Mid and South Essex NHS Foundation Trust, Chelmsford · The Princess Alexandra Eye Pavilion, Edinburgh · Royal Devon and Exeter Hospital, Exeter · Gartnavel General Hospital, Glasgow · Hull Royal Infirmary, Hull · Leicester Royal Infirmary, Leicester · Royal Liverpool University Hospital, Liverpool · Moorfields Eye Hospital, London · Barts Health NHST trust - Whipps Cross University Hospital, London · King's College Hospital NHS Foundation Trust, London · Imperial College Healthcare NHS Foundation Trust (The Western Eye Hospital), London · Maidstone and Tunbridge Wells NHS Trust, Maidstone · Manchester Royal Eye Hospital, Manchester · James Cook University Hospital, (South Tees NHSFT), Middlesbrough · Royal Victoria Infirmary, Newcastle upon Tyne · Nottingham University Hospitals, Nottingham · Oxford University Hospitals NHS Foundation Trust, Oxford · University Hospitals Plymouth NHST, Plymouth · University Hospital Southampton NHS Foundation Trust, Southampton · Sunderland Eye Infimary, Sunderland · Torbay and South Devon NHS, Torquay · New Cross Hosp, Royal Wolverhampton NHST, Wolverhampton

  Registry updated 2026-09-11

• NCT06659445

  Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

  Trial Treatment · Phase 2 · ONL Therapeutics

  Royal Victoria Hospital (Ophthalmology Research Suite, EODU), Belfast · Gloucestershire Hospitals NHS Foundation Trust, Gloucester · King's College Hospital NHS Foundation Trust, London · The Retina Clinic, London · Newcastle Upon Tyne NHS Foundation Trust, Newcastle · University Hospital Southampton NHS Foundation Trust, Southampton · Sunderland Eye Infirmary, Sunderland · Hull University Teaching Hospitals NHS Trust, Hull Royal Infirmary, York

  Registry updated 2026-09-10

• NCT06990269

  Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

  Trial Treatment · Phase 2 · ADARx Pharmaceuticals, Inc.

  Dorchester · Liverpool · London · Sunderland · Wolverhampton

  Registry updated 2026-09-03

• NCT06662162

  Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration

  Trial Treatment · i-Lumen Scientific AUS PTY LTD

  Queens University Belfast / Belfast City Hospital, Belfast · King's College Hospital, London · London North West University Healthcare, Middlesex · Sunderland Eye Infirmary, Sunderland

  Registry updated 2026-08-26

• NCT06604104

  Visual Frailty in Ageing

  Research · University of Edinburgh

  Anne Rowling Clinic, Edinburgh · The Princess Alexandra Eye Pavilion, Edinburgh

  Registry updated 2026-03-04

• NCT07170683

  Microperimetry Changes in Retinal Function in Macular Disorders

  Research · University of Nottingham

  Nottingham University Hospitals NHS Trust, Nottingham

  Registry updated 2025-09-12

• NCT06351657

  Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression

  Research · Medical University of Vienna

  Queen's Unviversity Belfast, Belfast

  Registry updated 2025-05-15

• NCT06351670

  Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression

  Research · Medical University of Vienna

  Queen's Unviversity Belfast, Belfast

  Registry updated 2025-05-15

• NCT06682455

  Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - SUMMIT (Part 2)

  Research · University of Southampton

  Frimley Health NHS Foundation Trust, Frimley · The Princess Alexandra Hospital Nhs Foundation Trust, Harlow · Moorfields Eye Hospital, London · St. Mary's Hospital, Newport · John Radcliffe Hospital, Oxford · Salisbury NHS Foundation Trust, Salisbury · University Hospital Southampton, Southampton

  Registry updated 2024-11-12

All Macular degeneration trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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