Migraine trials in United States

In United States 92 Also abroad 249

92 trials · From ClinicalTrials.gov, checked 10 Nov 2026. Ask the study team whether a trial fits you.

Phase 2RecruitingTrial-stage medicine
Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients
Where
Atlanta, Austin, Brooklyn, City of Saint Peters, Dallas, Las Vegas, Lemon Grove, Marlton, Memphis, Nashville, Orlando, Phoenix, Raleigh, Roslindale, Salt Lake City, Stamford, Walnut Creek, Waterbury, Westborough
Age
18 years to 65 years
People
108
Run by
Aspeya, Inc.
See details and how to joinNCT07646613Registry updated 2026-10-09
No phaseRecruitingResearch participation
RELAXaHEAD for Headache Patients (Phase III)
Where
New York
Age
16 years to 80 years
People
450
Run by
NYU Langone Health
See details and how to joinNCT06077838Registry updated 2026-10-08
Phase 3RecruitingTrial-stage medicine
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy
Where
New York
Age
18 years to 55 years
People
32
Run by
Columbia University
See details and how to joinNCT07629635Registry updated 2026-10-08
No phaseRecruitingResearch participation
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Where
Bethesda
Age
8 years to 70 years
People
1,260
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT05669703Registry updated 2026-10-07
Phase 3RecruitingTrial-stage medicine
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Where
Amherst, Anaheim, Ann Arbor, Austin, Bountiful, Brunswick, Cincinnati, Clinton, El Paso, Everett, Fort Collins, Franklin, Friendswood, Greensboro, Gulf Breeze, Homestead, Huntsville, Little Rock, Long Beach, Memphis, Miami, Morristown, Nashville, Newburgh, New York, Oceanside, Oklahoma City, Overland Park, Papillion, Philadelphia, Ridgeland, Salt Lake City, San Jose, Saraland, Spring Hill, The Woodlands, Walnut Creek, Waxahachie, West Chester
Age
6 years to 17 years
People
450 worldwide
Run by
AbbVie
See details and how to joinNCT05711394EU 2022-501100-94-00Registry updated 2026-10-06
Phase 1/2Not yet recruitingTrial-stage medicine
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
Where
Washington D.C.
Age
18 years to 65 years
People
24
Run by
George Washington University
See details and how to joinNCT06792500Registry updated 2026-10-05
Phase 2RecruitingTrial-stage medicine
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
Where
Camden
Age
18 years and over
People
80
Run by
Daniel A Tonetti, MD
See details and how to joinNCT07361549Registry updated 2026-10-01
No phaseNot yet recruitingResearch participation
Using Virtual Reality to Teach Mindfulness to People With Migraine
Where
Boston, Chestnut Hill
Age
18 years to 80 years
People
160
Run by
Brigham and Women's Hospital
See details and how to joinNCT07599228Registry updated 2026-09-30
Phase 1RecruitingTrial-stage medicine
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
Where
Cincinnati, Dallas, Hinesville, Minneapolis, Omaha, Philadelphia, Port Jefferson Station, Salt Lake City, Statesville, Tulsa, Washington D.C., Winston-Salem
Age
6 years to 11 years
People
16
Run by
Pfizer
See details and how to joinNCT06995729Registry updated 2026-09-28
No phaseRecruitingResearch participation
The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and Fibromyalgia
Where
Bridgewater
Age
18 years and over
People
120 worldwide
Run by
Theranica
See details and how to joinNCT07841509Registry updated 2026-09-25
Phase 4RecruitingTrial-stage medicine
A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
Where
Brooklyn
Age
18 years to 65 years
People
80
Run by
Antonios Likourezos
See details and how to joinNCT06473597Registry updated 2026-09-24
No phaseRecruitingResearch participation
EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
Where
Tacoma
Age
18 years to 64 years
People
50
Run by
Cortex Neurovascular
See details and how to joinNCT07652034Registry updated 2026-09-23
No phaseRecruitingTrial-stage medicine
Responding With Evidence and Access for Childhood Headaches
Where
Amherst, Atlanta, Aurora, Austin, Birmingham, Cincinnati, Columbus, Huntington, Louisville, Memphis, New Orleans, Philadelphia, Phoenix, San Francisco, Wilmington
Age
10 years to 17 years
People
400
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT05889624Registry updated 2026-09-21
No phaseRecruitingResearch participation
Puberty, Testosterone, and Brain Development
Where
Aurora
Age
12 years to 20 years
People
100
Run by
University of Colorado, Denver
See details and how to joinNCT06670053Registry updated 2026-09-21
Phase 4RecruitingTrial-stage medicine
Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications
Where
Phoenix
Age
18 years and over
People
200
Run by
Mayo Clinic
See details and how to joinNCT06401642Registry updated 2026-09-17
No phaseEnrolling by invitationResearch participation
A Comprehensive Digital Care Program for Migraine Management
Where
San Francisco
Age
18 years and over
People
140
Run by
Hinge Health, Inc
See details and how to joinNCT07642414Registry updated 2026-09-17
Phase 3RecruitingTrial-stage medicine
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Where
Ames, Amherst, Anaheim, Annandale, Atlanta, Aurora, Austin, Baltimore, Beaumont, Bountiful, Boynton Beach, Brunswick, Burnsville, Centennial, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Colorado Springs, Columbus, Dallas, Decatur, DeSoto, El Paso, Everett, Fort Myers, Franklin, Fresno, Friendswood, Gainesville, Glenwood, Greenville, Greer, Gulf Breeze, Hialeah, Hickory, Hoffman Estates, Hollywood, Homestead, Hot Springs, Houston, Huntsville, Kerrville, Kingwood, Lakeland, Lampasas, La Palma, Lexington, Little Rock, Long Beach, Los Angeles, Mansfield, Mequon, Meridian, Miami, Modesto, Morristown, Mount Kisco, Nashua, Nashville, New York, Norfolk, Oceanside, Oklahoma City, Orange City, Orlando, Overland Park, Ozark, Palm Harbor, Papillion, Petal, Philadelphia, Phoenix, Plano, Port Jefferson Station, Portland, Richmond, Ridgeland, Runnemede, Salt Lake City, San Antonio, San Diego, San Jose, Saraland, Savannah, Scottdale, Smithfield, Spring Hill, Stamford, Stockbridge, Syracuse, Tacoma, Tampa, The Woodlands, Upland, Walnut Creek, Washington D.C., Waxahachie, West Chester, Weston, Wichita, Winnetka, Winter Park, Woodstock
Age
6 years to 17 years
People
1,059 worldwide
Run by
AbbVie
See details and how to joinNCT05125302Registry updated 2026-09-14
No phaseRecruitingResearch participation
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Where
Iowa City
Age
18 years to 80 years
People
120
Run by
Randy Kardon
See details and how to joinNCT03694626Registry updated 2026-09-08
No phaseRecruitingResearch participation
Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine
Where
Baltimore
Age
18 years to 80 years
People
13
Run by
Johns Hopkins University
See details and how to joinNCT07223008Registry updated 2026-09-03
No phaseNot yet recruitingResearch participation
The Effect of Static Magnetic Fields on Neuroinflammation in Migraine
Where
Charlestown
Age
18 years to 65 years
People
10
Run by
Marco Loggia
See details and how to joinNCT07584382Registry updated 2026-08-31
No phaseNot yet recruitingResearch participation
Behavioral Resources and Awareness for Veterans With Episodic Migraine: Impact on Neurological Disability and Quality of Life- Pilot
Where
San Antonio, West Haven
Age
18 years and over
People
24
Run by
Yale University
See details and how to joinNCT07792291Registry updated 2026-08-31
No phaseRecruitingResearch participation
A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
Where
Charlotte, Newnan, Olney
Age
22 years to 84 years
People
150
Run by
Salvia BioElectronics
See details and how to joinNCT07719608Registry updated 2026-08-28
No phaseRecruitingResearch participation
Emgality for Migraine in Breastmilk
Where
San Francisco
Age
18 years to 45 years
People
30
Run by
University of California, San Francisco
See details and how to joinNCT06085144Registry updated 2026-08-11
No phaseRecruitingResearch participation
Headache Ear Auditory Dizziness Sinus (HEADS) Registry
Where
North Kingstown
Age
18 years and over
People
10,000
Run by
Association of Migraine Disorders
See details and how to joinNCT07754266Registry updated 2026-08-10
Phase 3RecruitingTrial-stage medicine
BOTOX® vs. XEOMIN® for Chronic Migraine
Where
Jacksonville
Age
18 years to 89 years
People
128
Run by
Naval Medical Center Camp Lejeune
See details and how to joinNCT05598723Registry updated 2026-07-22

All Migraine trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error