Multiple sclerosis trials in United States

In United States 186 Also abroad 506

138 of 186 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Austin, Birmingham, Boston, Buffalo, Chapel Hill, Charlottesville, Chicago, Cleveland, Columbus, Draper, Honolulu, Kansas City, Knoxville, Madison, New York, Novi, Omaha, Philadelphia, Rockville, San Diego, Santa Rosa, Seattle, Shreveport, Tampa, Towson, Tucson, Worcester
Age
18 years to 80 years
People
100
Run by
Reunion Neuroscience Inc
See details and how to joinNCT07002034
Phase 3Taking people
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Where
Bradenton, Columbus, Cordova, Greenville, Kansas City, Livingston, Maitland, Milwaukee, Orlando, Pheonix, Raleigh, Roeland Park, San Antonio, Scottsdale, Sherman, St Louis, Tampa, West Hollywood
Age
18 years to 60 years
People
705 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07067463 · EU 2025-524316-11-00
Phase 2Taking people
Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis
Where
Baltimore, Kansas City, New York
Age
18 years to 60 years
People
120
Run by
Johns Hopkins University
See details and how to joinNCT07497399
No phaseTaking people
Investigating the Impact of Treadmill-integrated Virtual Reality Training on Walking Outside the Clinic
Where
Atlanta
Age
18 years and over
People
10
Run by
Shepherd Center, Atlanta GA
See details and how to joinNCT07927439
No phaseNot yet taking people in United States
Non-invasive Brain Stimulation to Improve Memory in Multiple Sclerosis
Where
Richardson
Age
18 years to 64 years
People
80
Run by
The University of Texas at Dallas
See details and how to joinNCT07914257
Phase 3Taking people
Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
Where
Boston
Age
25 years to 75 years
People
48
Run by
MGH Institute of Health Professions
See details and how to joinNCT06136728
Phase 2Taking people
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
Where
Buffalo
Age
55 years to 75 years
People
30
Run by
State University of New York at Buffalo
See details and how to joinNCT06463743
No phaseNot yet taking people in United States
Evaluating the Effect of the Zeen Mobility Device on Clinical Practicality, Safety, and Impact (Via Assessments of Walking, Standing Tolerance, Balance, Endurance, Effort, and Participation in Daily Tasks) in an Outpatient Rehabilitation Setting for Individuals With Mobility Impairments.
Where
Pomona
Age
18 years and over
People
20
Run by
Casa Colina Hospital and Centers for Healthcare
See details and how to joinNCT07923201
Phase 3Taking people
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Where
Albuquerque, Boca Raton, Boston, Bradenton, Clearwater, Columbus, Cordova, Fullerton, Greenville, Indianapolis, Kansas City, Maitland, Naples, New York, Oklahoma City, Phoenix, Rochester Hills, Roeland Park, San Antonio, Scottsdale, Sherman, St Louis, Tampa, Torrance, West Hollywood, Worcester
Age
18 years to 60 years
People
990 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07299019 · EU 2025-524322-18-00
No phaseTaking people
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
Where
Gainesville
Age
18 years to 100 years
People
15
Run by
University of Florida
See details and how to joinNCT07376772
No phaseTaking people
HOBSCOTCH-MS-Efficacy Trial
Where
Lebanon
Age
20 years to 75 years
People
125
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT06951919
No phaseTaking people
Understanding and Enhancing Human Health and Movement
Where
Cleveland
Age
18 years and over
People
75
Run by
Louis Stokes VA Medical Center
See details and how to joinNCT07738978
Phase 4Taking people
A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
Where
Atlanta, Birmingham, Cordova, Fort Collins, Maitland, Savannah, Scottsdale
Age
18 years to 65 years
People
100 worldwide
Run by
Genentech, Inc.
See details and how to joinNCT07609719
Phase 2Taking people
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
Where
Atlanta, Columbus, Dallas, Oklahoma City, Raleigh, Stony Brook, Tampa
Age
18 years to 70 years
People
20
Run by
Sundance Biosciences, Inc.
See details and how to joinNCT07840326
Phase 2/3Taking people
Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis
Where
Salt Lake City
Age
10 years to 17 years
People
240 worldwide
Run by
TG Therapeutics, Inc.
See details and how to joinNCT07220252 · EU 2025-522257-19-00
No phaseTaking people
Dry Needling in Multiple Sclerosis
Where
Tampa
Age
18 years to 80 years
People
24
Run by
University of South Florida
See details and how to joinNCT07615725
Phase 2Taking people
Efgartigimod for the Treatment of Acute Optic Neuritis
Where
Boston
Age
18 years and over
People
20
Run by
Anastasia Vishnevetsky, MD, MPH
See details and how to joinNCT06453694
Phase 1Taking people
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
Where
Ann Arbor, Cleveland, Columbus, La Jolla, Milwaukee, New York, Omaha, Rochester
Age
18 years and over
People
100
Run by
TG Therapeutics, Inc.
See details and how to joinNCT06680037
Phase 2Taking people
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Where
Aurora, Birmingham, Cincinnati, Columbus, Farmington, Foxborough, Kansas City, Kirkland, Knoxville, Lewisville, Naples, Philadelphia, Scottsdale, Southfield, St Louis, Tampa
Age
18 years to 70 years
People
200 worldwide
Run by
Celgene
See details and how to joinNCT06782490
No phaseNot yet taking people in United States
Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis
Where
Chicago
Age
18 years to 70 years
People
100 worldwide
Run by
Otto Bock Healthcare Products GmbH
See details and how to joinNCT07897760
Phase 3Taking people
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Where
Albuquerque, Altamonte Springs, Austin, Boston, Buffalo, Burlington, Centerville, Chapel Hill, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Fargo, Farmington Hills, Fort Worth, Foxborough, Gainesville, Greenfield, Greenville, Hollywood, Irvine, Kansas City, Knoxville, Las Vegas, Maitland, Miami, Milwaukee, Naples, Olney, Orlando, Owosso, Plano, Portland, Raleigh, Richmond, Scottsdale, St Louis, Tallahassee, Tampa, Teaneck, Vero Beach, Washington D.C.
Age
40 years to 70 years
People
400 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06846281 · EU 2023-509275-17-00
Phase 3Taking people
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
Where
Atlanta, Birmingham, Boston, Charlotte, Chicago, Cincinnati, Cleveland, Cullman, Dayton, Farmington, Fort Collins, Foxborough, Golden Valley, Greenville, Houston, Indianapolis, Iowa City, Kirkland, Knoxville, Lutherville, Milwaukee, New York, North Worcester, Oklahoma City, Orange, Overland Park, Plymouth, Raleigh, Salt Lake City, Savannah, Seattle, Spokane, St Louis, Tampa, Vienna, Washington D.C., Wellesley
Age
18 years to 65 years
People
800 worldwide
Run by
TG Therapeutics, Inc.
See details and how to joinNCT05877963 · EU 2024-519284-18-00
No phaseTaking people
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
Where
Atlanta
Age
18 years to 89 years
People
138
Run by
Emory University
See details and how to joinNCT06495138
No phaseNot yet taking people in United States
Efficacy of Seated Physical Activity INtervention(SPIN) for Wheelchair Users With Multiple Sclerosis
Where
Houston
Age
18 years and over
People
100
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07891520
Phase 1/2Taking people
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Where
Bethesda
Age
18 years to 120 years
People
250
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03109288