Multiple sclerosis trials in United States

In United States 186 Also abroad 506

48 of 186 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Where
Bethesda
Age
1 month to 99 years
People
2,400
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT00794352
No phaseTaking people
Kesimpta (Ofatumumab) Pregnancy Registry
Where
La Jolla
Age
18 years to 100 years
People
725
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05634967
No phaseTaking people
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Where
Altamonte Springs, Amherst, Ann Arbor, Atlanta, Aurora, Austin, Avon, Baltimore, Basalt, Bethlehem, Billings, Birmingham, Boca Raton, Boston, Bridgewater, Burlington, Centerville, Charlotte, Charlottesville, Cherry Hill, Chicago, Cincinnati, Clearwater, Cleveland, Coeur d'Alene, Colorado Springs, Columbus, Cullman, Dallas, Denver, Detroit, Edinburg, Evanston, Farmington, Fort Collins, Franklin, Freehold, Fresno, Frisco, Gainesville, Gilbert, Glen Burnie, Golden Valley, Grand Junction, Greenfield, Hartford, Honolulu, Huntsville, Kirkland, Knoxville, Lake Success, Las Vegas, Lexington, Lincoln, Livingston, Louisville, Lubbock, Maitland, Miami, Milwaukee, Mobile, Morgantown, Mount Juliet, Naples, Nashville, Neenah, Neptune City, New Bern, Newport Beach, New York, Norfolk, Norman, Ogden, Omaha, Orange, Orlando, Owosso, Paramus, Pensacola, Phoenix, Plymouth, Portland, Raleigh, Rochester Hills, Roeland Park, Salem, Salt Lake City, San Antonio, Savannah, Scottsdale, Smyrna, Spring Hill, Teaneck, The Bronx, Toledo, Urbana, Vienna, Virginia Beach, Washington D.C., Waukesha, West Hollywood, Weston
Age
18 years and over
People
2,000 worldwide
Run by
TG Therapeutics, Inc.
See details and how to joinNCT06433752
No phaseTaking people
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
Where
Bethesda
Age
2 years to 120 years
People
700
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT01730131
No phaseTaking people
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
Where
Wilmington
Age
15 years to 50 years
People
728
Run by
TG Therapeutics, Inc.
See details and how to joinNCT06433765
No phaseTaking people
iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis
Where
Waltham
People
20,000
Run by
Accelerated Cure Project for Multiple Sclerosis
See details and how to joinNCT02486562
No phaseTaking people
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Where
Bethesda
Age
18 years to 120 years
People
3,750
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT00001248
No phaseTaking people
Care in Multiple Sclerosis (MS)
Where
Aurora, Birmingham, Boston, Cleveland, Houston, San Francisco
Age
18 years to 29 years
People
300
Run by
NYU Langone Health
See details and how to joinNCT07011914
No phaseTaking people
Early Versus Delayed Start of Ocrevus Zunovo for Relapsing Multiple Sclerosis
Where
Oklahoma City
Age
18 years and over
People
45
Run by
Oklahoma Medical Research Foundation
See details and how to joinNCT07878923
No phaseTaking people
Identifying and Characterizing Preclinical MS
Where
North Haven
Age
18 years and over
People
1,000
Run by
Yale University
See details and how to joinNCT05787795
No phaseTaking people
A Study Comparing Effectiveness of Kesimpta® (Ofatumumab) Versus Ocrevus® (Ocrelizumab) in Real-world Practice
Where
East Hanover
Age
18 years to 100 years
People
7,466
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07779460
No phaseTaking people
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Where
Aurora, Durham
People
908 worldwide
Run by
Biogen
See details and how to joinNCT05658497
No phaseTaking people
Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)
Where
San Francisco
Age
18 years to 64 years
People
250
Run by
University of California, San Francisco
See details and how to joinNCT06940323
No phaseTaking people
Brain Imaging and Immune Changes During Remibrutinib Treatment in Multiple Sclerosis.
Where
St Louis
Age
40 years to 70 years
People
15
Run by
Washington University School of Medicine
See details and how to joinNCT07758270
No phaseTaking people
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
Where
St Louis
Age
18 years and over
People
80
Run by
Washington University School of Medicine
See details and how to joinNCT07115017
No phaseTaking people
Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia
Where
Lawrenceville
People
15
Run by
Bristol-Myers Squibb
See details and how to joinNCT07732907
No phaseNot yet taking people in United States
Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study
Where
Seattle
Age
50 years to 70 years
People
14
Run by
University of Washington
See details and how to joinNCT07723599
No phaseTaking people
Ocrevus Zunovo for MS: Mixed Methods
Where
Chicago
Age
18 years and over
People
150
Run by
Northwestern University
See details and how to joinNCT07710105
No phaseTaking people
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
Where
New York
Age
18 years and over
People
170
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT05982925
No phaseEnrolling by invitation
Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab
Where
Baltimore
Age
18 years to 70 years
People
75
Run by
Johns Hopkins University
See details and how to joinNCT06167642
No phaseTaking people
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
Where
Bethesda
Age
18 years to 120 years
People
250
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT02659956
No phaseTaking people
Intestinal Immunity in Neurologic Disease
Where
North Haven
Age
18 years to 99 years
People
100
Run by
Yale University
See details and how to joinNCT06329453
No phaseEnrolling by invitation
Serum Auto-Antibodies in Neurological Diseases
Where
Sacramento
Age
18 years and over
People
120
Run by
University of California, Davis
See details and how to joinNCT00704626
No phaseTaking people
Genes and Environment in Multiple Sclerosis
Where
Bethesda, Boston, New York, Pittsburgh
Age
18 years and over
People
5,000
Run by
Columbia University
See details and how to joinNCT01353547
No phaseTaking people
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
Where
Boston
Age
18 years and over
People
800
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT04603196