Myeloproliferative neoplasms trials in Canada

In Canada 21 Also abroad 210

21 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)
Where
Montreal
Age
18 years and over
People
460 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07357727 · EU 2025-523555-66-00
Phase 4Taking people
Asciminib Roll-over Study
Where
Montreal
Age
7 years to 100 years
People
347 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT04877522 · EU 2023-507557-16-00
Phase 2Taking people
Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)
Where
Calgary, Edmonton, Greenfield Park, Halifax, Montreal, Ottawa, Toronto, Winnipeg
Age
18 years to 59 years
People
335 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05554406
Phase 3Taking people
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
Where
Calgary, Hamilton, Lévis, London, Montreal, Toronto
Age
18 years and over
People
324 worldwide
Run by
Takeda
See details and how to joinNCT07623161 · EU 2026-525660-17-00
Phase 3Taking people
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
Where
Hamilton, Kingston, Montreal, Québec, Toronto, Vancouver
Age
18 years and over
People
426 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07623200 · EU 2026-525398-38-00
Phase 2/3Taking people
A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025).
Where
Toronto
Age
18 years and over
People
380 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07722611 · EU 2026-525630-38-00
Phase 1Taking people
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Where
Calgary, Montreal, Toronto
Age
18 years and over
People
300 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06150157 · EU 2023-505584-36-00
Phase 2Taking people
Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis
Where
Montreal, Toronto, Vancouver
Age
18 years and over
People
68 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06517875 · EU 2024-518225-15-00
Phase 2Taking people
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Where
Calgary, Edmonton, Greenfield Park, Halifax, Hamilton, Montreal, Ottawa, Toronto, Winnipeg
Age
18 years and over
People
2,000 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05564390
Phase 1Taking people
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
Where
Montreal, Toronto
Age
18 years and over
People
218 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07441694 · EU 2026-525217-31-00
Phase 1/2Taking people
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Where
Calgary, Hamilton, Montreal, Toronto, Vancouver
Age
18 years and over
People
240 worldwide
Run by
Sumitomo Pharma America, Inc.
See details and how to joinNCT04176198 · EU 2022-502597-16-00
Phase 2Taking people
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
Where
Edmonton, Toronto
Age
18 years and over
People
140 worldwide
Run by
Cogent Biosciences, Inc.
See details and how to joinNCT04996875 · EU 2024-511407-42-00
No phaseTaking people
Project: Every Child for Younger Patients With Cancer
Where
Calgary, Edmonton, Halifax, Hamilton, Kingston, London, Montreal, Ottawa, Québec, Saskatoon, Sherbrooke, St. John's, Toronto, Vancouver, Winnipeg
Age
Up to 25 years
People
75,000 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT02402244
Phase 2Taking people
Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms
Where
Toronto
Age
18 years and over
People
40
Run by
University Health Network, Toronto
See details and how to joinNCT05074355
Phase 3Taking people
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
Where
Toronto
Age
18 years and over
People
665 worldwide
Run by
Celgene
See details and how to joinNCT04064060
Phase 2Not yet taking people in Canada
Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX)
Where
Winnipeg
Age
18 years and over
People
75
Run by
University of Manitoba
See details and how to joinNCT07528417
Phase 2Taking people
Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Where
Winnipeg
Age
18 years and over
People
75
Run by
University of Manitoba
See details and how to joinNCT06599762
Phase 2Taking people
A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
Where
Montreal
Age
18 years and over
People
58 worldwide
Run by
Karyopharm Therapeutics Inc
See details and how to joinNCT05980806
No phaseTaking people
OURA Ring Wearable Testing in MDS Patients: a Feasibility and Discovery Pilot Study
Where
Toronto
Age
18 years and over
People
60
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT06270771
No phaseNot yet taking people in Canada
EVAluation of Erythrocytosis PRospEctive Cohort STudy
Where
London
Age
18 years and over
People
1,500
Run by
Cyrus Hsia
See details and how to joinNCT06785870
No phaseTaking people
Myeloproliferative Neoplasms (MPNs) Patient Registry
Where
Toronto
People
5,000
Run by
University Health Network, Toronto
See details and how to joinNCT02760238