Smoking and nicotine dependence trials in United States

In United States 164 Also abroad 269

164 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseNot yet taking people in United States
Quit-Smoking Study for Native Hawaiians
Where
Honolulu
Age
18 years to 80 years
People
75
Run by
University of Hawaii
See details and how to joinNCT07075575
No phaseTaking people
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Where
New Haven
Age
21 years and over
People
256
Run by
Yale University
See details and how to joinNCT06077240
Early phase 1Taking people
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
Where
San Diego
Age
22 years and over
People
200
Run by
University of California, San Diego
See details and how to joinNCT06582888
No phaseTaking people
ACT Lung Health Intervention: Phase Two
Where
Boston
Age
18 years to 100 years
People
50
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT06945120
No phaseNot yet taking people in United States
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
Where
New Haven
Age
11 years to 15 years
People
1,251
Run by
Yale University
See details and how to joinNCT07460622
No phaseTaking people
Enhancing Smoking Cessation Via Telehealth Options in Primary Care
Where
Charleston
Age
18 years and over
People
672
Run by
Medical University of South Carolina
See details and how to joinNCT05493254
No phaseTaking people
Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments
Where
Charleston
Age
18 years and over
People
288
Run by
Medical University of South Carolina
See details and how to joinNCT05764759
No phaseEnrolling by invitation
Rural COPD E-Visit Study
Where
Charleston
Age
40 years and over
People
144
Run by
Medical University of South Carolina
See details and how to joinNCT06236347
No phaseTaking people
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
Where
Tulsa
Age
18 years and over
People
150
Run by
University of Oklahoma
See details and how to joinNCT07080788
No phaseTaking people
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
Where
Atlanta
Age
21 years to 35 years
People
84
Run by
Emory University
See details and how to joinNCT07165808
Phase 3Taking people
Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment
Where
Kansas City
Age
18 years and over
People
500
Run by
University of Kansas Medical Center
See details and how to joinNCT05732272
Phase 2Taking people
Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD
Where
Durham
Age
18 years to 75 years
People
50
Run by
VA Office of Research and Development
See details and how to joinNCT05723588
Phase 3Taking people
Tobacco Education and Lung Health Study (TEAL)
Where
Washington D.C.
Age
50 years to 80 years
People
1,188
Run by
Georgetown University
See details and how to joinNCT06290869
No phaseTaking people
Take A Break - Rural
Where
Winston-Salem
Age
18 years and over
People
800
Run by
Wake Forest University Health Sciences
See details and how to joinNCT05790486
Phase 2Taking people
The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence
Where
Gainesville
Age
21 years to 75 years
People
76
Run by
University of Florida
See details and how to joinNCT05814055
No phaseTaking people
Veteran Social Support for Enhancing Use of Smoking Cessation Treatment
Where
Minneapolis
Age
18 years and over
People
2,376
Run by
VA Office of Research and Development
See details and how to joinNCT05868421
No phaseTaking people
Harm Reduction for Smokers With Mental Illness
Where
Louisville, Providence
Age
21 years and over
People
250
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT06543407
No phaseEnrolling by invitation
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
Where
Rochester
Age
21 years and over
People
120
Run by
Rochester Institute of Technology
See details and how to joinNCT06619964
No phaseTaking people
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Where
Durham
Age
21 years and over
People
60
Run by
Duke University
See details and how to joinNCT06747871
Phase 1Taking people
Oral Cannabidiol for Tobacco Cessation
Where
Baltimore
Age
18 years to 65 years
People
50
Run by
Johns Hopkins University
See details and how to joinNCT05445804
Phase 2Taking people
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
Where
New York
Age
21 years and over
People
70
Run by
VapeAway
See details and how to joinNCT07322432
Phase 2Taking people
A Trial of Varenicline for E-cigarette Cessation
Where
Charleston, New Haven
Age
18 years and over
People
326
Run by
Yale University
See details and how to joinNCT07040566
Phase 2Taking people
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
Where
Los Angeles
Age
18 years to 65 years
People
64
Run by
University of California, Los Angeles
See details and how to joinNCT06617312
Phase 4Taking people
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
Where
San Francisco
Age
18 years and over
People
150
Run by
University of California, San Francisco
See details and how to joinNCT07148232
No phaseTaking people
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
Where
Newark
Age
18 years to 55 years
People
42
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT06695884