Prostate cancer trials in United States

In United States 655 Also abroad 1489

655 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Where
Allentown, Atlanta, Aurora, Austin, Bala-Cynwyd, Baltimore, Bethesda, Boston, Camden, Canton, Chandler, Cincinnati, Cleveland, Dallas, Denver, Durham, East Brunswick, Edgewood, Edwards, Fairfax, Fountain Valley, Grand Junction, Hershey, Houston, Jackson, Knoxville, La Jolla, Lakewood, Lincoln, Lisle, Little Rock, Los Alamitos, Los Angeles, Louisville, Metairie, Mineola, Myrtle Beach, New Brunswick, New York, Orlando, Pembroke Pines, Pittsburgh, Riverside, Saint Louis Park, Saint Paul, San Diego, Santa Monica, Sarasota, Seattle, Sioux Falls, Springdale, Springfield, Sterling Heights, St Louis, Sugar Land, The Bronx, The Woodlands, Towson, Watertown, Wichita
Age
18 years and over
People
800 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07225946 · EU 2025-522713-29-00
Phase 1Taking people
A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer
Where
Cleveland, New York, Sarasota
Age
18 years and over
People
40 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07319871
Phase 2Not yet taking people in United States
Whole Versus Partial Gland Boost During Prostate SBRT
Where
Omaha
Age
19 years and over
People
160
Run by
University of Nebraska
See details and how to joinNCT07574489
Phase 3Taking people
A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)
Where
Bala-Cynwyd, Canton, Charlotte, Coral Springs, Dallas, Fort Worth, Glendale, Holland, Houston, Jeffersonville, Lancaster, Murray, Myrtle Beach, Nashville
Age
18 years and over
People
600 worldwide
Run by
ORIC Pharmaceuticals
See details and how to joinNCT07723248 · EU 2026-525340-15-00
Phase 1Taking people
A Study of JNJ-98768111 in Participants With Advanced Prostate Cancer
Where
Grand Rapids, New York, Sarasota, West Valley City
Age
18 years and over
People
160 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07746713 · EU 2026-525894-37-00
Phase 2Taking people
A Study of JNJ-101556143 in Participants With Metastatic Prostate Cancer
Where
Carmel, Chicago Ridge, Germantown, Lafayette, Largo, Plymouth, Syracuse
Age
18 years and over
People
100 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07832292
Phase 2Not yet taking people in United States
Testosterone-Informed De-Escalation in Metastatic Prostate Cancer (TIDE PC)
Where
Omaha
Age
19 years and over
People
56
Run by
University of Nebraska
See details and how to joinNCT07904026
Phase 3Taking people
A Study of JNJ-101556143 With Best Supportive Care in Participants With Metastatic Prostate Cancer
Where
El Paso, Murray, The Woodlands
Age
18 years and over
People
400 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07906717 · EU 2026-527547-18-00
Phase 2Taking people
Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05873192
No phaseTaking people
Evaluating Tolerability of ePUHRT With Brachytherapy Boost
Where
Indianapolis
Age
18 years and over
People
31
Run by
Indiana University
See details and how to joinNCT06817668
Phase 4Taking people
Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance
Where
Miami
Age
18 years and over
People
35
Run by
University of Miami
See details and how to joinNCT07278362
Phase 2Taking people
Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial
Where
Seattle
Age
18 years and over
People
60
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07466498
Phase 1Taking people
A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer
Where
Boston, Grand Rapids, Irvine, Kansas City, Metairie, Miami, Omaha, Pittsburgh
Age
18 years and over
People
138
Run by
Aktis Oncology, Inc.
See details and how to joinNCT07581184
Phase 4Taking people
Autonomic and Renal Contributions to Hypertension With ADT
Where
Richmond
Age
40 years and over
People
60
Run by
Virginia Commonwealth University
See details and how to joinNCT07848828
No phaseTaking people
CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer
Where
Atlanta
Age
18 years and over
People
100
Run by
Emory University
See details and how to joinNCT07859722
Phase 1Taking people
A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors
Where
Houston, Miami
Age
18 years and over
People
152
Run by
Aktis Oncology, Inc.
See details and how to joinNCT07887971
No phaseTaking people
Evaluating Prostate Cancer Patient Natural Killer Cell Function Across Racial Background and Addressing Functional Disparities With Trispecific Killer Engagers
Where
Minneapolis
Age
18 years and over
People
45
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT07910019
Phase 2Taking people
A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer
Where
Basking Ridge, Commack, Duarte, Harrison, Hartford, Los Angeles, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
102
Run by
City of Hope Medical Center
See details and how to joinNCT05751434
Phase 2Taking people
Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial
Where
Chicago
Age
18 years and over
People
50
Run by
Sean Sachdev
See details and how to joinNCT06499870
Phase 3Taking people
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
Where
Anaheim, Bonney Lake, Chandler, Fayetteville, Federal Way, Fountain Valley, Gig Harbor, Gilbert, Glendale, Goodyear, Laguna Hills, Little Rock, Los Angeles, Mesa, Myrtle Beach, Phoenix, Puyallup, Quincy, Rogers, San Antonio, San Diego, Santa Fe, Scottsdale, Seattle, Springdale, Tacoma, The Bronx
Age
18 years and over
People
900 worldwide
Run by
Pfizer
See details and how to joinNCT06629779 · EU 2024-511652-40-00
Phase 2Taking people
The COSMYC Trial (COmbined Suppression of MYC)
Where
Baltimore
Age
18 years and over
People
50
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT06922318
Phase 3Taking people
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Baltimore, Billings, Boston, Chicago, Clermont, Clovis, Columbus, Dallas, Detroit, Duarte, Grand Island, Grand Rapids, Hackensack, Houston, Irvine, Jacksonville, La Jolla, Las Vegas, Lexington, Long Beach, Los Angeles, Madison, Memphis, Milwaukee, Nashville, New Haven, New York, Omaha, Orange, Orange City, Palo Alto, Philadelphia, Phoenix, Portland, Roanoke, Rochester, Saint Louis Park, Saint Paul, Seattle, Washington D.C., West Haven, Williamsville
Age
18 years and over
People
1,440 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06925737 · EU 2024-517423-40-00
Phase 1/2Taking people
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Where
Doral, Fort Worth, Hialeah, Houston, Lake Success, Los Angeles, Morristown, New York, Plantation, Tamarac
Age
18 years and over
People
160 worldwide
Run by
Eikon Therapeutics
See details and how to joinNCT07262619 · EU 2026-525248-13-00
No phaseTaking people
Pluvicto Real-world Investigation in Survival in Metastatic CRPC
Where
East Hanover
Age
18 years and over
People
1,085
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07697989
No phaseTaking people
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
Where
Washington D.C.
Age
18 years and over
People
15,000
Run by
Cancer Support Community, Research and Training Institute, Philadelphia
See details and how to joinNCT02333604