Prostate cancer trials in United States

In United States 655 Also abroad 1490

655 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
Where
Albuquerque, Aurora, Cleveland, Dayton, Detroit, Dothan, Duarte, Grand Rapids, Houston, Irvine, Metairie, Miami, Myrtle Beach, Nashville, New Hyde Park, Newport Beach, New York, O'Fallon, Omaha, Phoenix, Pittsburgh, Portland, Salt Lake City, San Francisco, St Louis, Tacoma, Westbrook
Age
18 years and over
People
670 worldwide
Run by
AstraZeneca
See details and how to joinNCT07611110
Phase 2Taking people
Measuring Circulating Tumor Deoxyribonucleic Acid Tumor Fraction to Guide Early 177Lu-PSMA-617 Treatment Discontinuation in Patients With Metastatic Castration-Resistant Prostate Cancer, DYNAMO Trial
Where
Seattle
Age
18 years and over
People
64
Run by
University of Washington
See details and how to joinNCT07698535
No phaseTaking people
Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis
Where
Bethesda
Age
3 years and over
People
1,100
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01441089
No phaseTaking people
Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer
Where
Bethesda
Age
18 years and over
People
10,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03354416
No phaseTaking people
Men at High Genetic Risk for Prostate Cancer
Where
Bethesda
Age
30 years to 75 years
People
500
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03805919
No phaseTaking people
Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer
Where
Bethesda
Age
18 years and over
People
508
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04692675
No phaseTaking people
Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer
Where
Duarte
Age
18 years and over
People
30
Run by
City of Hope Medical Center
See details and how to joinNCT04775355
No phaseTaking people
A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies
Where
Bethesda
Age
18 years and over
People
1,100
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04923178
Phase 2Taking people
18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy
Where
Bethesda
Age
18 years to 120 years
People
130
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05155046
Phase 2Taking people
Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor
Where
Bethesda
Age
18 years to 120 years
People
42
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05616650
Phase 2Taking people
Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy
Where
Bethesda
Age
18 years to 120 years
People
65
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06096870
Phase 1Taking people
A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer
Where
Boston, Chicago, Cleveland, Metairie, Miami, New York, Omaha, Palo Alto, Portland, Rochester, San Diego, Tampa
Age
18 years and over
People
136 worldwide
Run by
AstraZeneca
See details and how to joinNCT06879041
Phase 3Taking people
A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer
Where
Albany, Atlanta, Aurora, Austin, Cincinnati, Fairfax, Fort Myers, Houston, Myrtle Beach, Nashville, Niles, Norfolk, Peoria, Rockville, Santa Barbara, St. Petersburg, Tyler, West Palm Beach, White Plains, Wichita Falls
Age
18 years and over
People
736 worldwide
Run by
BioNTech SE
See details and how to joinNCT07365995 · EU 2025-524445-27-00
Phase 1Taking people
A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)
Where
Dallas, Hackensack, Houston, Nashville, New York, Seattle, St Louis
Age
18 years and over
People
110
Run by
Moonlight Bio, Inc
See details and how to joinNCT07488923
Phase 1Taking people
A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy
Where
Little Rock
Age
18 years to 100 years
People
34
Run by
University of Arkansas
See details and how to joinNCT06044025
Phase 1/2Taking people
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
Where
Boston, Denver, Houston, Miami, Nashville, San Antonio
Age
18 years and over
People
330
Run by
ModeX Therapeutics, An OPKO Health Company
See details and how to joinNCT06239194
Phase 3Taking people
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
Where
Albuquerque, Athens, Baltimore, Boston, Charleston, Chattanooga, Chicago, Cincinnati, Cooperstown, Denver, Detroit, East Brunswick, Fort Myers, Gahanna, Homewood, Iowa City, Kansas City, Lakeway, Metairie, Miami, Milwaukee, Morgantown, Myrtle Beach, New York, Omaha, Orange, Orlando, Palo Alto, Rochester, San Antonio, Santa Barbara, Scarborough, Seattle, St Louis, Syracuse, Tacoma, The Bronx, The Woodlands, Tucson, Voorhees Township
Age
18 years to 100 years
People
940 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06855277
No phaseTaking people
Low-Count Quantitative SPECT for Men Treated With Radium-223
Where
St Louis
Age
18 years and over
People
38
Run by
Washington University School of Medicine
See details and how to joinNCT07221825
Phase 1/2Taking people
A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC
Where
Durham, El Paso, Los Angeles, Murray
Age
18 years and over
People
123 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07226986 · EU 2025-521859-23-00
No phaseTaking people
Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial
Where
Ann Arbor
Age
50 years to 75 years
People
800
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07526545
No phaseTaking people
A Study of Real-World Characteristics, Treatment Patterns, and Clinical Outcomes in Patients With Metastatic Castration-Resistant Prostate Cancer
Where
East Hanover
Age
18 years to 115 years
People
17,111
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07677254
No phaseTaking people
A Study of Real-World Characteristics, Treatment Patterns, and Outcomes Among mCRPC Patients Previously Treated With an Androgen Receptor Pathway Inhibitor, Taxane-Based Chemotherapy, and Lutetium-177 Vipivotide Tetraxetan
Where
East Hanover
Age
18 years to 115 years
People
1,067
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07677267
Phase 1Not yet taking people in United States
Escalating Cycle 1 Dose of Lu-177-PSMA-617 for the Treatment of Metastatic Castration Resistant Prostate Cancer
Where
Ann Arbor
Age
18 years and over
People
20
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07682649
Phase 3Taking people
Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)
Where
Aberdeen, Albuquerque, Ames, Austin, Baltimore, Beverly Hills, Camden, Canton, Chicago, Cincinnati, Dallas, Detroit, Elk Grove Village, Fort Worth, Grand Rapids, Greenville, Hinsdale, Honolulu, Hot Springs, Longview, Los Alamitos, Los Angeles, Margate, Marshall, Miami, Mitchell, Nashville, Orlando, Pierre, Portland, Salt Lake City, San Diego, Shirley, Sioux Falls, Spokane, Springdale, Towson, Wichita Falls, Yankton
Age
18 years and over
People
1,330 worldwide
Run by
AstraZeneca
See details and how to joinNCT07711002 · EU 2026-526275-38-00
No phaseTaking people
Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer
Where
Albert Lea, Eau Claire, La Crosse, Mankato, Rochester
Age
18 years and over
People
164
Run by
Mayo Clinic
See details and how to joinNCT06325046