Pulmonary arterial hypertension trials in United States

In United States 108 Also abroad 305

108 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Natural History of Sickle Cell Disease
Where
Bethesda, Washington D.C.
Age
2 years to 90 years
People
3,500
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00081523
No phaseTaking people
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Where
Bethesda
Age
18 years to 100 years
People
270
Run by
National Institutes of Health Clinical Center (CC)
See details and how to joinNCT01730092
Phase 2/3Not yet taking people in United States
An Open-Label Extension Study to Evaluate Inhaled Treprostinil SMI in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Where
Boston, Chapel Hill, Charleston, Chicago, Dallas, Detroit, Falls Church, Lexington, Palo Alto, Philadelphia, Phoenix, Pittsburgh, San Francisco, Tucson
Age
18 years and over
People
400
Run by
United Therapeutics
See details and how to joinNCT07923526
Phase 2Not yet taking people in United States
Study of Treprostinil Administered Via Soft Mist Inhaler (SMI) in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Where
Birmingham, Boston, Chapel Hill, Charleston, Chicago, Dallas, Detroit, Falls Church, Lexington, Palo Alto, Philadelphia, Phoenix, Pittsburgh, San Francisco, Tucson
Age
18 years and over
People
40
Run by
United Therapeutics
See details and how to joinNCT07923591
No phaseTaking people
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Where
Abington, Albuquerque, Atlanta, Augusta, Austin, Boston, Chapel Hill, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Dallas, Detroit, Gainesville, Grand Rapids, Hackensack, Hershey, Houston, Indianapolis, Iowa City, Kansas City, Lexington, Little Rock, Louisville, Manhasset, Marietta, Memphis, Milwaukee, Minneapolis, Newark, New York, Oakbrook Terrace, Oklahoma City, Omaha, Philadelphia, Phoenix, Pittsburgh, Plano, Portland, Richmond, Rochester, Sacramento, Salt Lake City, San Francisco, Temple, The Bronx, Tulsa, Washington D.C., Weston
Age
18 years and over
People
850 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT06526195
No phaseTaking people
Rehabilitation Program for People With Methamphetamine-Associated Cardiopulmonary Conditions
Where
Salt Lake City
Age
18 years and over
People
45
Run by
Michael Incze
See details and how to joinNCT07915882
Phase 2Taking people
Spironolactone for Pulmonary Arterial Hypertension
Where
Bethesda
Age
18 years to 100 years
People
70
Run by
National Institutes of Health Clinical Center (CC)
See details and how to joinNCT01712620
No phaseTaking people
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Where
Albuquerque, Ann Arbor, Birmingham, Bossier City, Boston, Buffalo, Charleston, Chicago, Cleveland, Dallas, Denver, Hannibal, Houston, Indianapolis, Jackson, Knoxville, Lexington, Little Rock, Minneapolis, Morgantown, New York, Oklahoma City, Omaha, Orlando, Philadelphia, Phoenix, Reno, Richmond, Riverside, Royal Oak, Salt Lake City, San Antonio, Shreveport, Springfield, Winston-Salem
Age
18 years and over
People
900
Run by
Tempus AI
See details and how to joinNCT06911632
Phase 2Taking people
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
Where
Aurora, Cincinnati, Los Angeles, Milwaukee, Nashville, Palo Alto, Philadelphia, San Francisco, Seattle, Washington D.C.
Age
1 year to 17 years
People
42 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05587712 · EU 2023-504861-22-00
Phase 1/2Taking people
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
Where
Dallas, Greenville, Kansas City
Age
18 years and over
People
126
Run by
35Pharma Inc., a GSK company
See details and how to joinNCT07123779
Phase 1/2Taking people
A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults
Where
Boston, Providence, Tampa
Age
18 years and over
People
90 worldwide
Run by
35Pharma Inc., a GSK company
See details and how to joinNCT07143448
Phase 4Taking people
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
Where
Ann Arbor, Atlanta, Aurora, Birmingham, Boston, Charleston, Houston, Indianapolis, Irvine, Little Rock, Los Angeles, Louisville, Memphis, Nashville, Palo Alto, Portland, Salt Lake City, San Diego, Seattle
Age
0 months to 1 month
People
900
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT05213676
Phase 2Taking people
A Clinical Trial of NS-863 in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Where
Knoxville
Age
18 years to 80 years
People
177 worldwide
Run by
NS Pharma, Inc.
See details and how to joinNCT07441278
Phase 3Taking people
An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Where
Bend, Naples
Age
18 years and over
People
344 worldwide
Run by
Insmed Incorporated
See details and how to joinNCT07234032 · EU 2025-521769-29-00
Phase 2Taking people
Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
Where
Allen Park, Boise, Phoenix, San Francisco
Age
18 years to 80 years
People
25 worldwide
Run by
Tectonic Operating Company, Inc.
See details and how to joinNCT07473700
No phaseTaking people
Ventilator Pressure and Optimization of Compliance and Hemodynamics
Where
Birmingham
Age
7 days to 30 days
People
24
Run by
University of Alabama at Birmingham
See details and how to joinNCT06512935
Phase 3Taking people
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Where
Bend, Chapel Hill, Cincinnati, Durham, Fresno, Gainesville, Kansas City, Los Angeles, Naples, New York, Philadelphia, Phoenix, Richmond, Salt Lake City, San Francisco, Santa Barbara, St. Petersburg, Tampa
Age
18 years and over
People
344 worldwide
Run by
Insmed Incorporated
See details and how to joinNCT07179380 · EU 2025-521558-40-00
Phase 2Taking people
Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)
Where
Aurora, Boston, Cincinnati, Omaha
Age
18 years and over
People
99 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07318597 · EU 2024-514754-79-00
Phase 3Taking people
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Where
Bethesda
Age
18 years to 100 years
People
210
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT07613099
Phase 2Not yet taking people in United States
Phase IIA Study of Belzutifan in EPAS1-, EGLN1-, or VHL-Mutant Erythrocytosis
Where
Salt Lake City
Age
18 years and over
People
16
Run by
University of Utah
See details and how to joinNCT07895966
No phaseTaking people
Pulmonary Hypertension (PH) Biorepository for Translational Research
Where
Baltimore, Bethesda, Falls Church
Age
18 years to 100 years
People
1,000
Run by
National Institutes of Health Clinical Center (CC)
See details and how to joinNCT07647549
Phase 2Not yet taking people in United States
LAM-001 for the Treatment of Sarcoidosis Associated Pulmonary Hypertension (SAPH)
Where
Philadelphia
Age
18 years to 80 years
People
60
Run by
IRulya Therapeutics Inc.
See details and how to joinNCT07886554
No phaseTaking people
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Where
Boston, Cleveland, Detroit, Houma, Manhasset, Mechanicsburg, New Haven, New York, Tucson, Tulsa, Weston, Wynnewood
Age
18 years to 85 years
People
750 worldwide
Run by
Pulnovo Medical, Inc.
See details and how to joinNCT07214376
Phase 3Enrolling by invitation
Long-Term Open-Label Extension Study of Oral Levosimendan
Where
Boston, Charleston, Chicago, Durham, Madison, Minneapolis, New York, Omaha, Rochester, St Louis
Age
18 years and over
People
800
Run by
Tenax Therapeutics, Inc.
See details and how to joinNCT07436689
Phase 2Taking people
LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Where
Boston, New Haven, Philadelphia, Tucson
Age
18 years to 85 years
People
85
Run by
IRulya Therapeutics Inc.
See details and how to joinNCT05798923