Sarcoma trials in United States

In United States 300 Also abroad 605

300 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Where
Aurora, Boston, Fargo, Grand Rapids, Houston, Iowa City, Kansas City, Los Angeles, New Brunswick, New Haven, New York, Philadelphia, Portland, Salt Lake City, Sioux Falls, St. Petersburg, Valhalla
Age
6 months to 25 years
People
90 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06395103 · EU 2023-507178-41-00
Phase 2Taking people
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Where
Bethesda
Age
18 years to 120 years
People
320
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06503146
Phase 1Taking people
Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)
Where
Ann Arbor, Baltimore, Boston, Houston, Los Angeles, New York, Philadelphia, Pittsburgh, Rochester
Age
2 years and over
People
50 worldwide
Run by
Amgen
See details and how to joinNCT07297979
No phaseNot yet taking people in United States
my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults
Where
Boston
Age
15 years to 24 years
People
143
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT07516353
No phaseTaking people
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Where
Sioux Falls
People
20,000
Run by
Sanford Health
See details and how to joinNCT01793168
Phase 1/2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Boston, Grand Rapids, Houston, Los Angeles, Nashville, New Haven, Newton, Trumbull
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
Phase 2Taking people
Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor
Where
Ann Arbor, Atlanta, Aurora, Baltimore, Birmingham, Boston, Chicago, Cincinnati, Dallas, Durham, Houston, Indianapolis, Kansas City, Los Angeles, Memphis, Minneapolis, Nashville, New York, Orange, Palo Alto, Philadelphia, Pittsburgh, Portland, Salt Lake City, San Francisco, Seattle, St Louis, St. Petersburg, Valhalla, Washington D.C.
Age
12 years to 39 years
People
55
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04616560
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Grand Rapids, Houston, Lake Success, Los Angeles, Portland, West Valley City
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 1/2Taking people
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Where
Cleveland, Columbus, Dallas, Houston, Kansas City, Lexington, Los Angeles, Madison, Miami, New York, Omaha, Pittsburgh, Rochester, St Louis
Age
18 years to 90 years
People
112
Run by
Perspective Therapeutics
See details and how to joinNCT06710756
Phase 1Taking people
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors
Where
Madison
Age
7 months to 21 years
People
22
Run by
University of Wisconsin, Madison
See details and how to joinNCT02508038
Phase 1Taking people
Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors
Where
Cincinnati, Houston, Palo Alto, Philadelphia, San Francisco
Age
24 months to 18 years
People
20 worldwide
Run by
ITM Solucin GmbH
See details and how to joinNCT06441331 · EU 2024-512831-66-00
Phase 1Taking people
A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies
Where
Boston, Duarte, Houston, Newport Beach, New York
Age
16 years and over
People
171
Run by
SEED Therapeutics, Inc.
See details and how to joinNCT07197554
No phaseTaking people
International PPB/DICER1 Registry
Where
Minneapolis
Age
0 Minutes to 100 years
People
3,400
Run by
Children's Hospitals and Clinics of Minnesota
See details and how to joinNCT03382158
Phase 2Taking people
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Where
Baltimore, Boston, Dallas, Houston, Little Rock, Madison, Memphis, New York, Orange, Phoenix, San Francisco, Washington D.C.
People
90
Run by
Carl Allen
See details and how to joinNCT04079179
Phase 3Taking people
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Where
Albany, Bakersfield, Beverly Hills, Billings, Cincinnati, Houston, Kansas City, Kettering, Lancaster, Madison, Miami Beach, Morristown, Skokie, Springfield, Stamford
Age
18 years and over
People
348 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06345729 · EU 2023-507776-42-00
Phase 2Taking people
A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma
Where
Chicago, Los Angeles, New York
Age
18 years and over
People
47 worldwide
Run by
Sarcoma Alliance for Research through Collaboration
See details and how to joinNCT06942442
Phase 2Taking people
A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors
Where
Atlanta, Basking Ridge, Boston, Chicago, Cincinnati, Commack, Fort Worth, Harrison, Los Angeles, Middletown, Montvale, New York, Palo Alto, Rockville Centre, St Louis, Washington D.C.
Age
12 months and over
People
45
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05985161
Phase 1/2Taking people
STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas
Where
Boston, Cleveland, Fairfax, Grand Rapids, Houston, Irving, Lake Success, Miami, New York, San Antonio, San Francisco, Seattle
Age
18 years and over
People
107
Run by
STORM Therapeutics LTD
See details and how to joinNCT06975293
Phase 2Taking people
A Study of Ivonescimab in People With Leiomyosarcoma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
20
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07516925
Phase 1Taking people
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
Where
Houston, San Antonio, Scottsdale
Age
18 years and over
People
30
Run by
SHY Therapeutics
See details and how to joinNCT07705334
Phase 1/2Taking people
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
Where
Houston
Age
18 years and over
People
74
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06498648
No phaseTaking people
LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy and Spectroscopy-based Molecular Urinalysis in Sarcoma Patients
Where
Charlotte, Winston-Salem
People
300
Run by
Wake Forest University Health Sciences
See details and how to joinNCT06958107
Phase 1Taking people
AOH1996 for the Treatment of Refractory Solid Tumors
Where
Duarte, Long Beach, Scottsdale
Age
18 years and over
People
92
Run by
City of Hope Medical Center
See details and how to joinNCT05227326
Phase 2Taking people
Nirogacestat in Patients With Kaposi Sarcoma
Where
St Louis
Age
18 years and over
People
28
Run by
AIDS Malignancy Consortium
See details and how to joinNCT07539454
Phase 2Taking people
PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility Study
Where
Houston
Age
18 years to 39 years
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07874828