Sarcoma trials in United States

In United States 300 Also abroad 605

300 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma
Where
Atlanta, Houston
Age
1 year to 30 years
People
24
Run by
Emory University
See details and how to joinNCT07144254
No phaseTaking people
Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
Where
Bethesda
Age
18 years to 120 years
People
1,029
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00006518
No phaseTaking people
Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
Where
Bethesda, Charlotte, New York, Orange, Washington D.C.
Age
4 weeks and over
People
6,035
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01109394
No phaseTaking people
Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease
Where
Bethesda
Age
18 years and over
People
280
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03300830
Phase 1/2Taking people
PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma
Where
Bethesda
Age
18 years to 99 years
People
80
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04303117
Phase 1Taking people
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV
Where
Bethesda
Age
18 years to 99 years
People
58
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04902443
Phase 1/2Taking people
Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma
Where
Bethesda
Age
18 years to 99 years
People
111
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04941274
No phaseTaking people
Natural History of KSHV-Associated Multicentric Castleman s Disease
Where
Bethesda
Age
18 years and over
People
195
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04968288
Phase 2Taking people
Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease
Where
Bethesda
Age
18 years to 120 years
People
40
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05907759
Phase 2Taking people
Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)
Where
Bethesda
Age
18 years to 120 years
People
75
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06052618
Phase 1Taking people
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Where
Bethesda
Age
18 years to 120 years
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06066138
Phase 1Taking people
FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma
Where
Bethesda
Age
3 years to 39 years
People
50
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06865664
Phase 2Taking people
Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial
Where
Duarte
People
22
Run by
City of Hope Medical Center
See details and how to joinNCT07650656
Phase 1Taking people
A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
Where
Boston, Fairfax, Houston, Los Angeles, Philadelphia, Salt Lake City, San Antonio, Sarasota, Tampa
Age
18 years and over
People
545
Run by
Kestrel Therapeutics, Inc.
See details and how to joinNCT07458347
Phase 2Taking people
XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
Where
Chicago
Age
18 years and over
People
73
Run by
Northwestern University
See details and how to joinNCT06571734
Phase 3Taking people
Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation
Where
Anaheim, Antioch, Atlanta, Bellflower, Billings, Birmingham, Buffalo, Chadds Ford, Decatur, Dublin, Fremont, Fresno, Irvine, Lebanon, Lewisburg, Los Angeles, Manchester, Marshfield, Menomonee Falls, Milwaukee, Modesto, Newark, New Berlin, Oak Creek, Oakland, Ontario, Orange, Philadelphia, Rancho Cordova, Redwood City, Richmond, Rohnert Park, Roseville, Sacramento, Saint Johnsbury, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, South San Francisco, Stockton, The Bronx, Vacaville, Vallejo, Walnut Creek, West Bend, Weston, Wilkes-Barre
Age
18 years and over
People
296
Run by
SWOG Cancer Research Network
See details and how to joinNCT07615049
No phaseTaking people
Ultra-Rapid Profiling and Drug Screening for Treatment Selection in Patients With Relapsed or Recurrent Rare Brain Tumors
Where
Washington D.C.
Age
Up to 45 years
People
20
Run by
Adriana Fonseca
See details and how to joinNCT07851636
No phaseTaking people
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
Where
Boston
Age
18 years and over
People
32
Run by
Massachusetts General Hospital
See details and how to joinNCT02792270
Phase 4Enrolling by invitation
LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology
Where
Baltimore, Boston, Camden, Cleveland, Columbia, Los Angeles, New Orleans, Tampa
Age
18 years and over
People
2,868
Run by
Massachusetts General Hospital
See details and how to joinNCT03244020
Phase 1Taking people
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Where
Princeton
Age
18 years and over
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07261631
Phase 2Taking people
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma
Where
New York, Tampa
Age
16 years to 70 years
People
80
Run by
Iovance Biotherapeutics, Inc.
See details and how to joinNCT07741877
Phase 1Taking people
Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors
Where
Cincinnati, Dallas, Lubbock, Milwaukee, Oklahoma City
Age
12 months to 20 years
People
30
Run by
South Plains Oncology Consortium
See details and how to joinNCT02013336
Phase 3Taking people
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Where
Ann Arbor, Atlanta, Aurora, Baltimore, Baton Rouge, Bellevue, Bemidji, Birmingham, Bismarck, Boston, Buffalo, Burlington, Camden, Charlotte, Chicago, Columbus, Creve Coeur, Dallas, Derby, Duarte, Durham, Eau Claire, Erie, Fairfield, Fargo, Gainesville, Glastonbury, Greenwich, Guilford, Hackensack, Hartford, Houston, Indianapolis, Irvine, Jacksonville, Jefferson Hills, Kansas City, Knoxville, La Jolla, Lake Success, Lebanon, Louisville, Manhasset, Marshfield, Mechanicsville, Menomonee Falls, Milwaukee, Mineola, Minocqua, Monroeville, Nashville, Natrona Heights, Neptune City, New Berlin, New Brunswick, New Haven, New Hyde Park, New York, North Haven, Oak Creek, Oklahoma City, Omaha, Orange, Overland Park, Paramus, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Rice Lake, Richmond, Roanoke, Rochester, Salt Lake City, Seattle, Sioux Falls, South Hill, Stamford, Stevens Point, St Louis, Stony Brook, Tampa, The Bronx, Trumbull, Waterbury, Waterford, West Bend, Westerly, Weston, Westwood, Wexford, Zion
Age
18 years and over
People
250 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT04031677
Phase 1/2Taking people
Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma
Where
Cleveland
Age
12 years and over
People
78 worldwide
Run by
MedPacto, Inc.
See details and how to joinNCT05588648
Phase 2Taking people
Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study
Where
Boston, Houston
Age
12 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05019703