Sickle cell disease trials in United States

In United States 133 Also abroad 204

34 of 133 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseEnrolling by invitation
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
Where
Bethesda, Fairfax
Age
18 years to 100 years
People
2,000
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00047996
No phaseTaking people
Natural History of Sickle Cell Disease
Where
Bethesda, Washington D.C.
Age
2 years to 90 years
People
3,500
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00081523
No phaseTaking people
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
Where
Bethesda
Age
18 years to 80 years
People
800
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT03685721
No phaseTaking people
HPC Offered for PRESERVE Expansion
Where
Birmingham, Columbus, Detroit, Duarte, Nashville
Age
12 years to 80 years
People
10
Run by
Ossium Health, Inc.
See details and how to joinNCT07145411
No phaseNot yet taking people in United States
Data Collection For Patients With Sickle Cell Disease
Where
Houston
Age
18 years and over
People
500
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07911618
No phaseTaking people
Blood Sampling for Research Related to Sickle Cell Disease
Where
Bethesda
Age
18 years to 100 years
People
250
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT00542230
No phaseTaking people
Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
Where
Bethesda
Age
18 years to 100 years
People
200
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05213572
No phaseTaking people
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Where
Bethesda
Age
18 years to 70 years
People
300
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03937817
No phaseTaking people
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Where
Bethesda
Age
18 years to 120 years
People
80
Run by
National Institutes of Health Clinical Center (CC)
See details and how to joinNCT05170412
No phaseTaking people
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)
Where
Cleveland
Age
12 years and over
People
100
Run by
University Hospitals Cleveland Medical Center
See details and how to joinNCT02824471
No phaseTaking people
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Where
Bethesda
Age
2 years to 99 years
People
50
Run by
National Human Genome Research Institute (NHGRI)
See details and how to joinNCT06944067
No phaseTaking people
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Where
Akron, Albuquerque, Atlanta, Austin, Baltimore, Boston, Buffalo, Chapel Hill, Charlotte, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Dayton, Detroit, Gainesville, Green Bay, Greenville, Hartford, Houston, Hyde Park, Indianapolis, Iowa City, Kansas City, Las Vegas, Little Rock, Los Angeles, Memphis, Miami, Milwaukee, Nashville, Newark, New Haven, New Orleans, New York, Norfolk, Oakland, Orlando, Peoria, Philadelphia, Phoenix, Pittsburgh, Providence, Reno, Rochester, Sacramento, San Antonio, San Bernardino, San Diego, San Francisco, Savannah, Scarborough, Seattle, St Louis, St. Petersburg, Tampa, The Bronx, Toledo, Washington D.C., Wilmington, Winston-Salem
People
3,000
Run by
American Thrombosis and Hemostasis Network
See details and how to joinNCT04398628
No phaseTaking people
Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)
Where
Memphis
Age
8 years and over
People
145
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT05810181
No phaseTaking people
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Where
Memphis
Age
12 years to 25 years
People
65
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06477289
No phaseTaking people
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation
Where
Cincinnati
People
200
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT04093986
No phaseTaking people
Investigation of the Genetics of Hematologic Diseases
Where
Memphis
People
1,716
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT02720679
No phaseTaking people
Sickle Cell Clinical Research and Intervention Program
Where
Baton Rouge, Charlotte, Memphis, Peoria
People
10,000
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT02098863
No phaseTaking people
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Where
Atlanta, Birmingham, Boston, Buffalo, Chapel Hill, Charlotte, Chicago, Columbus, Hackensack, Houston, Indianapolis, Memphis, New York, Oklahoma City, Philadelphia, Queens, Rochester, San Antonio, St Louis, The Bronx, Washington D.C., Wilmington
Age
3 years to 20 years
People
480 worldwide
Run by
University of Rochester
See details and how to joinNCT06941389
No phaseTaking people
Functional Ovarian Reserve in Sickle Cell Disease
Where
Memphis
Age
10 years to 18 years
People
440
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07392216
No phaseTaking people
Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders
Where
Memphis
Age
13 years and over
People
352
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT04416178
No phaseTaking people
ATHNdataset Registry
Where
Hickory
People
200,000
Run by
American Thrombosis and Hemostasis Network
See details and how to joinNCT06820515
No phaseTaking people
Sickle Cell Kidney Biorepository
Where
Dallas
Age
18 years to 65 years
People
800
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07064174
No phaseTaking people
A Long-term Follow-up Study in Patients Who Received BEAM-101
Where
Atlanta, Birmingham, Boston, Charleston, Cleveland, Detroit, Hackensack, Jacksonville, Memphis, Milwaukee, Minneapolis, Nashville, New York, Philadelphia, Phoenix, St Louis
Age
14 years to 37 years
People
50
Run by
Beam Therapeutics Inc.
See details and how to joinNCT07373639
No phaseTaking people
Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease
Where
Cincinnati
Age
6 months to 6 years
People
130 worldwide
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT07356050
No phaseTaking people
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
Where
Pittsburgh
Age
2 months to 60 years
People
50
Run by
Paul Szabolcs
See details and how to joinNCT04528355