Systemic sclerosis (scleroderma): open trials in United States

• NCT07085104

  A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

  Trial Treatment · Phase 1 · Allogene Therapeutics

  University of Colorado Denver, Aurora · Johns Hopkins Hospital, Baltimore · Medical University of South Carolina, Charleston · Atrium Health Rheumatology-Southpark, Charlotte · The University of Chicago Medical Center, Chicago · Duke University Medical Center, Durham · Astera Cancer Care, East Brunswick · Prisma Health, Greenville · University of Iowa, Iowa City · Mayo Clinic, Jacksonville · University of Kansas Medical Center, Kansas City · Loma Linda University Medical Center, Loma Linda · Norton Cancer Institute, St. Matthews Campus, Louisville · Icahn School of Medicine at Mount Sinai, New York · Mayo Clinic, Phoenix · LDS Hospital - lntermountain Health, Salt Lake City · New York Medical College, Valhalla

  Registry updated 2026-11-02

• NCT06733935

  A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)

  Trial Treatment · Phase 1/2 · Nkarta, Inc.

  Nkarta Investigational Site, Ann Arbor · Nkarta Investigational Site, Charlotte · Nkarta Investigational Site, Dallas · Nkarta Investigational Site, Fairway · Nkarta Investigational Site, Hackensack · Nkarta Investigational Site, Los Angeles · Nkarta Investigational Site, Minneapolis · Nkarta Investigational Site, New York · Nkarta Investigational Site, Plantation · Nkarta Investigational Site, Summit · Nkarta Investigational Site, Syracuse · Nkarta Investigational Site, Tampa

  Registry updated 2026-10-30

• NCT01793168

  Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

  Research · Sanford Health

  Sanford Health, Sioux Falls

  Registry updated 2026-10-28

• NCT06925542

  A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

  Trial Treatment · Phase 1 · CRISPR Therapeutics

  Boston Medical Center, Boston · University of North Carolina TraCS Institute - CTRC, Chapel Hill · Northwestern Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago · University of Iowa, Iowa City · UC San Diego Health, La Jolla · Tulane University Medical Center, New Orleans · Oregon Health Sciences University, Portland · Stanford University Medical Center, Redwood City · Washington University School of Medicine, St Louis

  Registry updated 2026-10-26

• NCT01776398

  Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

  Research · Weill Medical College of Cornell University

  Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine, New York

  Registry updated 2026-10-23

• NCT06328777

  RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis

  Trial Treatment · Phase 2/3 · Cabaletta Bio

  University of Michigan, Ann Arbor · Northwestern Memorial Hospital, Chicago · The University of Chicago Medical Center, Chicago · Duke University, Durham · Mayo Clinic Florida, Jacksonville · University of Kansas Medical Center, Kansas City · Yale University, New Haven · Columbia University Irving Medical Center, New York · Mayo Clinic - Rochester, Rochester · University of Rochester, Rochester

  Registry updated 2026-10-16

• NCT07873931

  A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases

  Trial Treatment · Phase 1 · Bristol-Myers Squibb

  Local Institution - 0004, Ann Arbor · Local Institution - 0052, Great Neck · Local Institution - 0007, Morristown · Local Institution - 0064, Newport Beach · Local Institution - 0062, Omaha · Local Institution - 0008, Philadelphia · Local Institution - 0013, Saint Paul · Local Institution - 0015, Salt Lake City · Local Institution - 0003, Seattle · Local Institution - 0005, Seattle · Local Institution - 0001, Worcester

  Registry updated 2026-10-14

• NCT07854483

  C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Systemic Sclerosis (SSc) Refractory to Standard Therapy

  Trial Treatment · Phase 1 · AbelZeta Inc.

  Research Site, Gilbert

  Registry updated 2026-10-13

• NCT03816345

  Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  Emory University Hospital/Winship Cancer Institute, Atlanta · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · National Institutes of Health Clinical Center, Bethesda · National Cancer Institute Developmental Therapeutics Clinic, Bethesda · University of Alabama at Birmingham Cancer Center, Birmingham · Massachusetts General Hospital Cancer Center, Boston · Dana-Farber Cancer Institute, Boston · University of Chicago Comprehensive Cancer Center, Chicago · Northwestern University, Chicago · Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters · Ohio State University Comprehensive Cancer Center, Columbus · Siteman Cancer Center at West County Hospital, Creve Coeur · UT Southwestern Simmons Cancer Center - RedBird, Dallas · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Wayne State University/Karmanos Cancer Institute, Detroit · University of Kansas Clinical Research Center, Fairway · UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth · HaysMed, Hays · UT MD Anderson Cancer Center, Houston · University of Kansas Cancer Center, Kansas City · University Health Truman Medical Center, Kansas City · University of Kansas Cancer Center - North, Kansas City · Lawrence Memorial Hospital, Lawrence · University of Kansas Cancer Center - Lee's Summit, Lee's Summit · University of Kentucky/Markey Cancer Center, Lexington · NYU Langone Hospital - Long Island, Mineola · Rutgers Cancer Institute of New Jersey, New Brunswick · Smilow Cancer Center/Yale-New Haven Hospital, New Haven · Yale University, New Haven · Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · NYP/Weill Cornell Medical Center, New York · University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City · The University of Kansas Cancer Center - Olathe, Olathe · University of Kansas Cancer Center-Overland Park, Overland Park · University of Kansas Hospital-Indian Creek Campus, Overland Park · Stanford Cancer Institute Palo Alto, Palo Alto · Thomas Jefferson University Hospital, Philadelphia · Mercy Hospital Pittsburg, Pittsburg · UPMC Hillman Cancer Center, Pittsburgh · UT Southwestern Clinical Center at Richardson/Plano, Richardson · VCU Massey Comprehensive Cancer Center, Richmond · University of California Davis Comprehensive Cancer Center, Sacramento · Salina Regional Health Center, Salina · Huntsman Cancer Institute/University of Utah, Salt Lake City · Washington University School of Medicine, St Louis · Siteman Cancer Center at Christian Hospital, St Louis · Siteman Cancer Center-South County, St Louis · University of Kansas Health System Saint Francis Campus, Topeka · MedStar Georgetown University Hospital, Washington D.C. · University of Kansas Hospital-Westwood Cancer Center, Westwood

  Registry updated 2026-10-05

• NCT02422875

  Comparative Autoantibody and Immunologic Cell Marker Study

  Research · Emory University

  Emory University/Winship Cancer Institute, Atlanta · Grady Health System, Atlanta · Emory University Hospital, Atlanta

  Registry updated 2026-10-01

• NCT04797286

  Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

  Trial Treatment · Phase 2 · Johns Hopkins University

  Johns Hopkins, Baltimore · Louisiana State University, New Orleans

  Registry updated 2026-09-28

• NCT01884051

  Hormonal, Metabolic, and Signaling Interactions in PAH

  Research · Vanderbilt University Medical Center

  Vanderbilt University Medical Center, Nashville

  Registry updated 2026-09-25

• NCT05878717

  A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease

  Trial Treatment · Phase 2/3 · GlaxoSmithKline

  GSK Investigational Site, Ann Arbor · GSK Investigational Site, Aurora · GSK Investigational Site, Baltimore · GSK Investigational Site, Chicago · GSK Investigational Site, Cincinnati · GSK Investigational Site, Denison · GSK Investigational Site, El Paso · GSK Investigational Site, Houston · GSK Investigational Site, Jacksonville · GSK Investigational Site, Los Angeles · GSK Investigational Site, Miami · GSK Investigational Site, New Brunswick · GSK Investigational Site, New York · GSK Investigational Site, Philadelphia · GSK Investigational Site, Phoenix · GSK Investigational Site, Pittsburgh · GSK Investigational Site, Potsdam · GSK Investigational Site, Scottsdale · GSK Investigational Site, Tucson · GSK Investigational Site, Upland · GSK Investigational Site, Washington D.C.

  Registry updated 2026-09-08

• NCT06195072

  Platform Clinical Study for Conquering Scleroderma

  Trial Treatment · Phase 2 · Scleroderma Research Foundation, Inc.

  University of Michigan, Ann Arbor · Emory University School of Medicine, Atlanta · Johns Hopkins University School Of Medicine, Baltimore · University of Alabama - Division of Pulmonary and Critical Care Medicine, Birmingham · Boston University (BU), Boston · Massachusetts General Hospital, Boston · Medical University of South Carolina (MUSC), Charleston · Northwestern University, Chicago · The University of Chicago Medical Center (UCMC), Chicago · Cleveland Clinic, Cleveland · Duke University Medical Center, Durham · Northwell Health, Great Neck · University of Texas Houston - Division of Rheumatology and Clinical Immunogenetics, Houston · University of Kansas, School of Medicine, Kansas City · University of California, Los Angeles (UCLA) Ronald Reagan Medical Center, Los Angeles · Keck School of Medicine at USC Medical Center, Los Angeles · Cedars-Sinai Medical Center, Los Angeles · Froedtert Hospital and the Medical College of Wisconsin, Milwaukee · Vanderbilt University Medical Center, Nashville · Meharry Medical College, Nashville · Robert Wood Johnson Medical School, New Brunswick · Yale University School of Medicine - Epilepsy, New Haven · Columbia University Medical Center, New York · Hospital for Special Surgery, New York · Stanford University Medical Center, Palo Alto · Temple University Hospital, Philadelphia · Thomas Jefferson University Hospital, Philadelphia · University of Pennsylvania, Philadelphia · University of Pittsburgh Medical Center, Pittsburgh · Oregon Health & Science University (OHSU), Portland · Mayo Clinic, Rochester · The University of Utah Health Sciences Center, Salt Lake City · Washington University School of Medicine, St Louis · Georgetown University Medical Center - Department of Rheumatology, Washington D.C.

  Registry updated 2026-08-18

• NCT03630211

  Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

  Trial Treatment · Phase 2 · Paul Szabolcs

  Children's Hospital of Pittsburgh of UPMC, Pittsburgh · University of Pittsburgh Medical Center, Pittsburgh

  Registry updated 2026-08-14

• NCT06991114

  AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.

  Trial Treatment · Phase 2 · Artiva Biotherapeutics, Inc.

  Artiva Investigational Site Arlington, Arlington · Artiva Investigational Site Bellaire, Bellaire · Artiva Investigational Site Charleston, Charleston · Artiva Investigational Site Charlotte, Charlotte · Artiva Investigational Site Chula Vista, Chula Vista · Artiva Investigational Site Covina, Covina · Artiva Investigational Site Gainesville, Gainesville · Artiva Investigational Site Iowa Great Falls, Great Falls · Artiva Investigational Site Hixson, Hixson · Artiva Investigational Site Iowa, Iowa City · Artiva Investigational Site Irving, Irving · Artiva Investigational Site Jackson, Jackson · Artiva Investigational Site Jupiter, Jupiter · Artiva Investigational Site Katy, Katy · Artiva Investigational Site Los Alamitos, Los Alamitos · Artiva Investigational Site Los Angeles, Los Angeles · Artiva Investigational Site Mesquite, Mesquite · Artiva Investigational Site Miami, Miami · Artiva Investigational Site Norcross, Norcross · Artiva Investigational Site Phoenix, Phoenix · Artiva Investigational Site Plantation, Plantation · Artiva Investigational Site Red Oak, Red Oak · Artiva Investigational Site Roanoke, Roanoke · Artiva Investigational Site Santa Ana, Santa Ana · Artiva Investigational Site Statesville, Statesville · Artiva Investigational Site Tucson, Tucson · Artiva Investigational Site Tuscaloosa, Tuscaloosa · Artiva Investigational Site Tustin, Tustin · Artiva Investigational Site Willowbrook, Willowbrook · Artiva Investigational Site Woodland, Woodland

  Registry updated 2026-07-31

• NCT07729995

  BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease

  Trial Treatment · Phase 1 · Luminary Therapeutics

  Boston Children's Hospital, Boston

  Registry updated 2026-07-28

• NCT07090226

  Diffuse Cutaneous Scleroderma (DSSc) SFDI Study

  Trial Treatment · Boston University

  Shapiro Outpatient Rheumatology Clinic at Boston Medical Center, Boston

  Registry updated 2026-07-23

• NCT07115745

  A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

  Trial Treatment · Phase 1 · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

  Brigham and Womens Hospital, Boston · Duke University, Durham

  Registry updated 2026-07-14

• NCT01808937

  Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository

  Research · University of Texas Southwestern Medical Center

  UT Southwestern Medical Center - Department of Dermatology, Dallas

  Registry updated 2026-05-12

• NCT07348263

  EFESO: Study on Juvenile Onset Eosinophilic Fasciitis

  Research · Meyer Children's Hospital IRCCS

  University of Alabama at Birmingham, Birmingham · SUNY Upstate Pediatric Rheumatology, Syracuse

  Registry updated 2026-03-11

• NCT04402086

  Rheumatology Patient Registry and Biorepository

  Research · Yale University

  Yale New Haven Hospital, New Haven

  Registry updated 2026-02-13

• NCT03276923

  Maternal Autoimmune Disease Research Alliance (MADRA) Registry

  Research · Duke University

  Duke University, Durham

  Registry updated 2026-01-08

• NCT06675344

  The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life

  Trial Treatment · Robyn T. Domsic, MD, MPH

  University of Michigan, Ann Arbor · Vanderbilt University Medical Center, Nashville · DelRicht Research Center, New Orleans · University of Pittsburgh and UPMC Scleroderma Center, Pittsburgh

  Registry updated 2026-01-08

• NCT01656447

  Scleroderma Registry & Repository at the Hospital for Special Surgery

  Research · Hospital for Special Surgery, New York

  Hospital for Special Surgery, New York

  Registry updated 2025-11-26

All Systemic sclerosis (scleroderma) trials and the map

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