Written based on 13 research studies on PubMed, searched on 2026. nov. 11..
The claim
Posts online say that CBD (cannabidiol) helps with psoriasis.
Where research stands
We found 17 published papers on CBD (cannabidiol) and psoriasis. They were published between 2019 and 2026. 1 of them is a study in people. 1 of them compared people who got it with a group that did not. 4 were studies in animals, and 3 were only in cells in the lab. 1 paper is a review that sums up other studies.
- 1In people1 with a comparison group
- 4In animals
- 3Only in the lab
What the studies found
We have not summed up these studies in words yet. The most important papers are listed under Sources.
Verdict
CBD (cannabidiol) has been tested in randomised trials in people with psoriasis.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Efficacy and safety of cannabidiol oil in psoriasis: a randomized, double-blind, placebo-controlled trial.2026 · J Dermatolog Treat · Randomised trial
- The Perspective of Cannabidiol in Psoriasis Therapy.2024 · Psoriasis (Auckl) · Review
- Encapsulation of Cannabidiol in Chitosan-Stabilized Argan Oil Nanoemulsion as a Potential Dermal Drug Delivery System for Psoriasis Treatment.2026 · Pharmaceutics · In animals
- Cannabidiol-loaded hydrogel microneedle patches inhibit TRIM14/TRAF3/ NF-κB axis for the treatment of psoriasis.2025 · Int J Biol Macromol · In animals
- Cannabidiol Alleviates Imiquimod-Induced Psoriasis by Inhibiting JAK2-STAT3 in a Mouse Model.2024 · Biomedicines · In animals
- Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.2023 · Molecules · In animals
- Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation.2021 · Int J Mol Sci · In the lab
- Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients.2020 · Int J Mol Sci · In the lab
- Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris.2020 · Biomolecules · In the lab
- Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris.2024 · Front Immunol · Other paper
- Cannabidiol Mediates In Vitro Attenuation of Proinflammatory Cytokine Responses in Psoriatic Disease.2024 · Cannabis Cannabinoid Res · Other paper
- Topical cannabidiol-based treatment for psoriasis: A dual-centre randomized placebo-controlled study.2022 · J Eur Acad Dermatol Venereol · Other paper
- Cannabidiol Decreases Metalloproteinase Activity and Normalizes Angiogenesis Factor Expression in UVB-Irradiated Keratinocytes from Psoriatic Patients.2021 · Oxid Med Cell Longev · Other paper
