Written based on 22 research studies on PubMed, searched on 2026. nov. 11..
The claim
Posts online say that stem cell treatment helps with psoriasis.
Where research stands
We found 94 published papers on stem cell treatment and psoriasis. They were published between 1997 and 2026. 2 of them are studies in people. None of them compared people who got it with a group that did not. 29 were studies in animals, and 11 were only in cells in the lab. 27 papers are reviews that sum up other studies. 4 research projects on stem cell treatment for psoriasis are funded and still running.
- 2In people
- 29In animals
- 11Only in the lab
What the studies found
We have not summed up these studies in words yet. The most important papers are listed under Sources.
Verdict
Stem cell treatment has been studied in people with psoriasis, but not in randomised trials.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- A phase 1, open-label study to determine safety and tolerability of the topical application of mesenchymal stem/stromal cell (MSC) exosome ointment to treat psoriasis in healthy volunteers.2025 · Cytotherapy · Study in people
- Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study.2022 · Signal Transduct Target Ther · Study in people
- Umbilical Cord Mesenchymal Stem Cells as a Meritorious Option to Treat Psoriasis.2026 · Curr Stem Cell Res Ther · Review
- Effectiveness of Exosomes from Different Mesenchymal Stem Cells in the Treatment of Psoriasis: A Murine Study and Meta-Analysis of Experimental Studies.2025 · Biomedicines · Review
- Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review.2025 · Front Immunol · Review
- Psoriasis, stem cells, and obesity: metabolic exploration for therapeutics.2025 · J Med Life · Review
- Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.2025 · Dermatol Pract Concept · Review
- Therapeutic Potential of Mesenchymal Stem Cells in Psoriasis.2025 · Cell Biochem Biophys · Review
- Piceatannol loaded Mesenchymal Stem Cells derived Exosomes for cutaneous regenerative treatment of psoriasis-like symptoms in Imiquimod-Induced Mice Model: Modulation of the JAK/STAT3 signaling pathway.2026 · Nanomedicine · In animals
- Dermal mesenchymal stem cells promote angiogenesis in HMEC-1 via activation of the angiopoietin 1/Tie2 pathway in psoriasis.2026 · Front Cell Dev Biol · In animals
- Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis.2026 · Stem Cell Res Ther · In animals
- Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT.2026 · Stem Cell Res Ther · In animals
- Amelioration of psoriasis-like skin lesions by human amniotic mesenchymal stem cells: insights from multiomics profiling in mice.2026 · Front Immunol · In animals
- Evaluation of 3D biomimetic microcarriers for enhancing therapeutic efficacy of human umbilical cord mesenchymal stem cells in psoriasis treatment.2026 · Front Immunol · In animals
- Effects of Adalimumab on Mitochondria of Psoriatic Mesenchymal Stem Cells.2025 · J Cell Mol Med · In the lab
- Normal dermal mesenchymal stem cells improve the functions of psoriatic keratinocytes by inducing autophagy.2025 · Acta Histochem · In the lab
- Distinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis.2024 · Arch Dermatol Res · In the lab
- Generation of two induced pluripotent stem cell lines from psoriatic patient with cardiovascular comorbidity.2023 · Stem Cell Res · In the lab
- Severe plaque psoriasis exacerbation during lenalidomide maintenance after autologous stem cell transplantation for multiple myeloma.2026 · JAAD Case Rep · Other paper
- Impulsive stem cell transplantation to modulate psoriasis: Insights of complex cytokine network.2026 · Math Biosci · Other paper
- Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series.2025 · Front Immunol · Other paper
- Proteomic Analysis of Mesenchymal Stem Cell-derived Exosomes in Psoriasis.2025 · Curr Mol Med · Other paper
