Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Omega-3 fatty acids (fish oil) helps with Migraine.
What has been studied
- 13In people13 randomised trials
- 1In animals
- 0Only in the lab
What the studies found
Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Migraine.
We found 24 published papers on Omega-3 fatty acids (fish oil) and Migraine. They were published between 1996 and 2026.
13 of them are studies in people (13 randomised trials), 5 are reviews, 1 are studies in animals and 0 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Omega-3 Supplementation with Lipid Biomarker Assessment in Youth with Migraine: A Quasi-Randomized Controlled Feasibility Trial.2026 · medRxiv · Randomised trial
- Omega-3 Supplementation Modulates Whole-Blood EPA and DHA Without Improving Patient-Reported Outcomes in Youth with Migraine: A Quasi-Randomized Pilot Trial.2026 · Nutrients · Randomised trial
- Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data.2025 · Nutrients · Randomised trial
- Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial.2025 · Headache · Randomised trial
- Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients.2024 · Brain Behav · Randomised trial
- A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.2024 · Brain Behav Immun · Randomised trial
- The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial.2023 · Immunopharmacol Immunotoxicol · Randomised trial
- The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial.2021 · BMC Res Notes · Randomised trial
- A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline.2018 · Nutr Neurosci · Study in people
- Omega 3 in Childhood Migraines: a Double Blind Randomized Clinical Trial.2016 · Iran J Child Neurol · Study in people
- Neuroimmunological effects of omega-3 fatty acids on migraine: a review.2024 · Front Neurol · Review
- High Dosage Omega-3 Fatty Acids Outperform Existing Pharmacological Options for Migraine Prophylaxis: A Network Meta-Analysis.2024 · Adv Nutr · Review
- Clinical use of omega-3 fatty acids in migraine: A narrative review.2020 · Medicine (Baltimore) · Review
- Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials.2018 · Nutr Neurosci · Review
- Molecular mechanisms of omega-3 fatty acids in the migraine headache.2017 · Iran J Neurol · Review
- Does fructose have a protective role on migraine?-experimental evidence in a rat model of metabolic syndrome under omega-3 supplementation.2022 · Ann Transl Med · In animals
- A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.2024 · Brain Behav Immun · Other paper
- Extreme ecchymoses in a migraine patient using concomitant treatment with calcitonin gene-related peptide receptor antibodies and fish oil supplements: a case report.2021 · BMC Neurol · Other paper
- Dietary omega 3 fatty acids for migraine.2021 · BMJ · Other paper
- Long-chain omega-3 fatty acids and headache in the U.S. population.2018 · Prostaglandins Leukot Essent Fatty Acids · Other paper