Omega-3 fatty acids (fish oil) & Sickle cell disease

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that Omega-3 fatty acids (fish oil) helps with Sickle cell disease.

What has been studied

• 7In people5 randomised trials
• 0In animals
• 0Only in the lab

What the studies found

!Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Sickle cell disease.

We found 17 published papers on Omega-3 fatty acids (fish oil) and Sickle cell disease. They were published between 1991 and 2023.

7 of them are studies in people (5 randomised trials), 1 are reviews, 0 are studies in animals and 0 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Cost-effectiveness analysis of adding omega-3 or vitamin D supplementation to standard therapy in treating painful crises of pediatric sickle cell disease patients.2022 · Eur Rev Med Pharmacol Sci · Randomised trial
2. Comparative effectiveness of adding Omega-3 or Vitamin D to standard therapy in preventing and treating episodes of painful crisis in pediatric sickle cell patients.2022 · Eur Rev Med Pharmacol Sci · Randomised trial
3. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease.2015 · Blood Cells Mol Dis · Randomised trial
4. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients.2013 · Prostaglandins Leukot Essent Fatty Acids · Randomised trial
5. Effect of omega-3 (n-3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial.2013 · Am J Clin Nutr · Randomised trial
6. An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease.2023 · Prostaglandins Leukot Essent Fatty Acids · Study in people
7. Pilot study of omega-3 fatty acid supplements in sickle cell disease.2011 · APMIS · Study in people
8. Biochemical and therapeutic effects of Omega-3 fatty acids in sickle cell disease.2020 · Complement Ther Med · Review
9. "Selection of statistical tests influences the interpretation of a study outcome" a comment on "Giriraja KV, Bhatnagar SK, Tomlinson L, Sancilio F. An open-label, multicenter, phase 2 study of a food enriched with docosahexaenoic acid in adults with sickle cell disease. Prostaglandins Leukot Essent Fatty Acids. 2023 Jun; 193:102574. Doi: 10.1016/j.plefa.2023.102574. Epub 2023 Apr 7. PMID: 37121179".2023 · Prostaglandins Leukot Essent Fatty Acids · Other paper
10. Omega 3 fatty acids - Potential modulators for oxidative stress and inflammation in the management of sickle cell disease.2022 · J Pediatr (Rio J) · Other paper
11. Pilot assessment of omega-3 fatty acids and potassium thiocyanate in sickle cell anemia patients with conditional peak systolic cerebral artery blood velocity.2021 · Blood Cells Mol Dis · Other paper
12. Impact of omega-3 fatty acids on calorie intake and certain anthropometric measurements in children with sickle cell disease in Saudi Arabia.2019 · Bioinformation · Other paper

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