Stem cell treatment & Sickle cell disease

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that Stem cell treatment helps with Sickle cell disease.

What has been studied

• 7In people
• 6In animals
• 1Only in the lab

What the studies found

!Stem cell treatment has been studied in people with Sickle cell disease, but not in randomised trials.

We found 160 published papers on Stem cell treatment and Sickle cell disease. They were published between 2001 and 2026.

7 of them are studies in people (0 randomised trials), 68 are reviews, 6 are studies in animals and 1 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Sustained improvement in sickle cell cardiomyopathy after haematopoietic stem cell transplantation is superior to that with disease-modifying therapy.2026 · Br J Haematol · Study in people
2. HLA-haploidentical hematopoietic stem cell transplantation in patients with sickle cell disease: results from the phase II DREP-HAPLO trial.2026 · Haematologica · Study in people
3. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease.2024 · Sci Rep · Study in people
4. In vivo measurement of RBC survival in patients with sickle cell disease before or after hematopoietic stem cell transplantation.2024 · Blood Adv · Study in people
5. Significant improvement of child physical and emotional functioning after familial haploidentical stem cell transplant.2022 · Bone Marrow Transplant · Study in people
6. Allogeneic stem cell transplantation with omidubicel in sickle cell disease.2021 · Blood Adv · Study in people
7. Haploidentical stem cell transplantation with CD3+-/CD19+- depleted peripheral stem cells for patients with advanced stage sickle cell disease and no alternative donor: results of a pilot study.2017 · Bone Marrow Transplant · Study in people
8. Sickle cell disease and hematopoietic stem cell transplantation: donor expansion, gene-modified grafts and prenatal horizons.2026 · Curr Opin Hematol · Review
9. Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations.2026 · Bone Marrow Transplant · Review
10. Medication Adherence in Pediatric Sickle Cell Disease and Hematopoietic Stem Cell Transplantation: An Integrative Review of Literature.2026 · J Pediatr Hematol Oncol Nurs · Review
11. Pre-transplant imaging evaluation in sickle cell disease: recommended protocols before allogeneic hematopoietic stem cell transplantation.2026 · Radiol Bras · Review
12. Curative Approach to the Treatment of Beta-Thalassemia and Sickle Cell Disease with Hematopoietic Stem Cell Transplantation.2026 · J Clin Med · Review
13. Implementation of a Dedicated Hematopoietic Stem Cell Transplant Program for Sickle Cell Disease in Lagos, Nigeria: Challenges and Opportunities.2026 · Hemoglobin · Review
14. Development of CRISPR_SCD001, an autologous hematopoietic stem cell gene therapy for sickle cell disease.2026 · Mol Ther · In animals
15. Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans.2026 · Sci Transl Med · In animals
16. Human haematopoietic stem cells remember inflammatory stress.2026 · Nature · In animals
17. Improved lentivector-modified hematopoietic stem cell transplantation in the Townes mouse model of sickle cell disease.2026 · Cytotherapy · In animals
18. In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery.2026 · Nat Biomed Eng · In animals
19. UM171 enhances fitness and engraftment of gene-modified hematopoietic stem cells from patients with sickle cell disease.2024 · Blood Adv · In animals
20. Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts.2026 · Stem Cell Res · In the lab
21. Is the use of GCSF to mobilize peripheral blood stem cells in sickle cell disease the answer to poor mobilization? Not so fast.2026 · Br J Haematol · Other paper
22. The use of G-CSF for stem cell mobilization in patients with sickle cell disease undergoing gene therapy.2026 · Br J Haematol · Other paper
23. Sickle cell disease-specific barriers to in vivo hematopoietic stem cell gene therapy.2026 · Semin Hematol · Other paper
24. Case Report: Recurrence of recipient-derived erythropoiesis in hematopoietic stem cell transplant for sickle-cell anemia: multi-lineage chimerism analysis as a tool to distinguish atypical pure red cell aplasia from poor erythroid engraftment.2026 · Front Immunol · Other paper

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