Stem cell treatment & ALS (motor neurone disease)

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that Stem cell treatment helps with ALS (motor neurone disease).

What has been studied

• 9In people1 randomised trial
• 15In animals
• 18Only in the lab

What the studies found

!Stem cell treatment has been tested in randomised trials in people with ALS (motor neurone disease).

We found 146 published papers on Stem cell treatment and ALS (motor neurone disease). They were published between 2002 and 2026.

9 of them are studies in people (1 randomised trials), 84 are reviews, 15 are studies in animals and 18 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis.2023 · Brain · Randomised trial
2. Safety and efficacy of first-in-man intrathecal injection of human astrocytes (AstroRx®) in ALS patients: phase I/IIa clinical trial results.2023 · J Transl Med · Study in people
3. Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study.2020 · Stem Cell Rev Rep · Study in people
4. The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus.2015 · Bull Exp Biol Med · Study in people
5. Human neural stem cell transplantation in ALS: initial results from a phase I trial.2015 · J Transl Med · Study in people
6. Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes.2014 · Neurosurgery · Study in people
7. Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility.2012 · Cell Transplant · Study in people
8. Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial.2010 · Exp Neurol · Study in people
9. Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients.2009 · Cytotherapy · Study in people
10. Motor Neuron Disease in a Dish: The Power of Human Induced Pluripotent Stem Cell-Derived Spinal Motor Neurons and Glial Cells.2026 · Cells · Review
11. Advances in the clinical application of mesenchymal stem cells for neurological disorders.2026 · Stem Cell Res Ther · Review
12. The Effectiveness Based on Optimal Dose and Administration Route, and Safety Profiles of Stem Cells and Derived Products in the Treatment of Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.2026 · Stem Cells Int · Review
13. Current and emerging therapeutic strategies for amyotrophic lateral sclerosis: from pharmacological approaches to gene and stem cell therapies.2026 · Front Neurol · Review
14. Revisiting oligodendrocytes in amyotrophic lateral sclerosis using human multicellular stem cell models.2026 · Trends Cell Biol · Review
15. Unraveling the Potential of Stem Cell Therapy in Motor Neuron Disease: A Narrative Review.2026 · CNS Neurol Disord Drug Targets · Review
16. Neural Stem Cell-Derived Extracellular Vesicles Improve CNS Delivery and Therapeutic Efficacy of Antisense Oligonucleotide in Amyotrophic Lateral Sclerosis.2026 · J Extracell Vesicles · In animals
17. Neural stem cell-derived small extracellular vesicles ameliorate disease progression in the SOD1 G93A murine model of amyotrophic lateral sclerosis.2026 · J Neuropathol Exp Neurol · In animals
18. Therapeutic potential of adipose-derived stem cell transplantation in amyotrophic lateral sclerosis: A combined clinical case and preclinical study.2026 · Tzu Chi Med J · In animals
19. Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics.2026 · Stem Cell Reports · In animals
20. Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery.2026 · Sci Rep · In animals
21. Metabolic reprogramming in amyotrophic lateral sclerosis ependymal stem cells by FM19G11 nanotherapy.2025 · Sci Rep · In animals
22. ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons.2026 · Commun Biol · In the lab
23. Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.2026 · Neural Regen Res · In the lab
24. Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS).2026 · Cell Death Dis · In the lab
25. Identification of Transcriptomic Differences in Induced Pluripotent Stem Cells and Neural Progenitors from Amyotrophic Lateral Sclerosis Patients Carrying Different Mutations: A Pilot Study.2025 · Cells · In the lab
26. Constructing functional neural circuits to model amyotrophic lateral sclerosis with induced pluripotent stem cell-derived brain organoids.2026 · Neural Regen Res · Other paper
27. The connection between unproven stem cell-based interventions and complementary and alternative medicine in crowdfunding for Amyotrophic Lateral Sclerosis.2026 · Amyotroph Lateral Scler Frontotemporal Degener · Other paper
28. Exosome-rich mesenchymal stem cell secretome improves strength in patients with amyotrophic lateral sclerosis, Kennedy disease, congenital myasthenic syndrome and Lewy body dementia.2025 · Am J Stem Cells · Other paper
29. Bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for amyotrophic lateral sclerosis.2024 · Neurodegener Dis Manag · Other paper

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