Written based on 18 research studies on PubMed, searched on 2026. nov. 11..
The claim
Posts online say that stem cell treatment helps with fatty liver disease (MASLD/MASH).
Where research stands
We found 53 published papers on stem cell treatment and fatty liver disease (MASLD/MASH). They were published between 2014 and 2026. None of them is a study in people. 26 were studies in animals, and 9 were only in cells in the lab. 16 papers are reviews that sum up other studies.
- 0In people
- 26In animals
- 9Only in the lab
What the studies found
We have not summed up these studies in words yet. The most important papers are listed under Sources.
Verdict
Stem cell treatment has been studied for fatty liver disease (MASLD/MASH) in animals, not yet in people.
Unproven means: it was only tested in animals or cells, or there is too little or mixed data from people. How we rate claims
What this means for you: Results in animals or in cells often do not hold in people. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Decoding dysbiosis: the role of gut microbiota in MASLD progression and emerging therapeutic interventions.2026 · J Physiol Biochem · Review
- Human Umbilical Cord Mesenchymal Stem Cells in Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) Therapy: Mechanisms, Clinical Efficacy, and Future Perspectives.2026 · Stem Cell Rev Rep · Review
- Mesenchymal stem cells and extracellular vesicles for MAFLD: from biological mechanisms to translational prospects.2026 · Stem Cell Res Ther · Review
- Therapeutic Role of Bone Marrow Mesenchymal Stem Cells (BMSCs) in Nonalcoholic Steatohepatitis (NASH) Cirrhosis.2025 · Curr Stem Cell Res Ther · Review
- Therapeutic potential of mesenchymal stem cell-derived extracellular vesicle in nonalcoholic fatty liver disease: a systematic review and meta-analysis of preclinical evidence.2025 · Lipids Health Dis · Review
- The therapeutic potential of different mesenchymal stem cells and their derived exosomes in metabolic dysfunction-associated steatotic liver disease.2025 · Front Endocrinol (Lausanne) · Review
- Human embryonic stem cell-derived mesenchymal stem cells ameliorate mitochondrial oxidative dysfunction in metabolic dysfunction-associated steatotic liver disease.2026 · Stem Cells Transl Med · In animals
- Anti-Inflammatory Effects of Adipose-Derived Mesenchymal Stem Cells and Their Exosomes in the Cortex and Striatum in a Nonalcoholic Steatohepatitis Model.2026 · Curr Stem Cell Res Ther · In animals
- Adipose-Derived Mesenchymal Stem Cells and Their Exosomes Ameliorate Sperm-related Abnormalities, Hormonal Imbalance, and Disrupted Testicular Autophagy in A Diet-Induced Murine Model for Non-Alcoholic Fatty Liver Disease.2026 · Reprod Sci · In animals
- Pathological transcriptional retention of Cyp26b1 in perirenal adipose-derived stem cells contributes to MASLD progression.2026 · Hepatol Int · In animals
- Therapeutic Potential of Mesenchymal Stem Cells Transplantation in Nonalcoholic Fatty Liver Disease of Polycystic Ovary Syndrome: A Cross-Talk Between Ovary and Liver.2026 · J Obstet Gynaecol Res · In animals
- Targeting cancer stem cells enhances multikinase inhibitor therapy in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma.2026 · Gut · In animals
- Induced Pluripotent Stem Cell-Derived Hepatocytes From Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease Exhibit Early Mitochondrial Dysfunction.2026 · Cell Mol Gastroenterol Hepatol · In the lab
- Human stem cell-derived hepatic cells recapitulate polygenic risk in MASLD development and highlight CD36 as a key mediator.2026 · Life Sci · In the lab
- Predicting metabolic dysfunction-associated steatotic liver disease risk using patient-derived induced pluripotent stem cells.2026 · Stem Cells Transl Med · In the lab
- NENF, as a Biomarker for the Development of NAFLD to Liver Cancer by Enhancing the Tumor-Like Stem Cell Properties of L02 Cells to Promote the Progression of NAFLD to Liver Cancer.2025 · J Biochem Mol Toxicol · In the lab
- Enhancing the functionality of mesenchymal stem cells: An attractive treatment strategy for metabolic dysfunction-associated steatotic liver disease?2024 · World J Stem Cells · Other paper
- Mesenchymal stem cells: A promising therapeutic avenue for non-alcoholic fatty liver disease.2024 · World J Stem Cells · Other paper
