Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.
Publikáció
Disrupting the PNPLA3-ABHD5 Interaction Stimulates Lipolysis and Improves PNPLA3-I148M-Associated Hepatic Steatosis.
2026. okt. 20.· Diabetes· PUBMED
Publikáció
PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD.
2026. szept. 27.· Journal of gastroenterology and hepatology· PUBMED
Vizsgálat
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
2026. szept. 1.· NA · NOT_YET_RECRUITING· CTGOV
Publikáció
Correction to 'Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD'.
2026. szept. 1.· Liver international : official journal of the International Association for the Study of the Liver· PUBMED
Publikáció
Gene-environment interaction between heavy alcohol use and PNPLA3 rs738409 in incident cirrhosis: Evidence from a diverse U.S. cohort.
2026. aug. 22.· Clinics and research in hepatology and gastroenterology· PUBMED
Publikáció
Genetic Susceptibility Versus Fibrosis Progression in North Indian Metabolic Dysfunction-Associated Steatotic Liver Disease: Distinct Roles of APOC3 and PNPLA3 in a Candidate Gene Study.
2026. aug. 21.· Journal of clinical and experimental hepatology· PUBMED
Publikáció
Erratum: A PNPLA3-NACC1-RIPK3 pathway mediates macrophage necroptosis and inflammation in MASLD.
2026. aug. 14.· Hepatology communications· PUBMED
Publikáció
Regulation of hepatic PNPLA3 gene expression by aerobic exercise and echium officinalis in a rat model of non-alcoholic fatty liver disease.
2026. aug. 12.· Molecular biology reports· PUBMED
Publikáció
Ambient fine particulate matter components and liver fat and stiffness in youth: metabolic vulnerability in PNPLA3 risk carriers.
2026. júl. 25.· Environment international· PUBMED
Publikáció
Molecular analysis of genes MICA, GPC3, PNPLA3, and TM6SF2 polymorphisms in patients of hepatocellular carcinoma.
2026. júl. 24.· Nucleosides, nucleotides & nucleic acids· PUBMED
Publikáció
Association between the PNPLA3 I148M (rs738409) polymorphism and risk of metabolic dysfunction-associated steatotic liver disease: a meta-analysis (2015-2025).
2026. júl. 21.· BMC gastroenterology· PUBMED
Publikáció
Targeting PNPLA3 I148M variant in MASLD: Cell-type specific mechanisms and precision therapy opportunities.
2026. júl. 21.· Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie· PUBMED
Vizsgálat
Influence of Donor and Recipient Genetic Polymorphisms on Graft Steatosis After Liver Transplant
2026. júl. 7.· NA · RECRUITING· CTGOV
Vizsgálat
Non-Invasive Diagnostic Panel for MASLD in Children With Obesity
2026. júl. 1.· NA · NOT_YET_RECRUITING· CTGOV
Publikáció
Prime editing enables isogenic modeling of PNPLA3-I148M-associated lipotoxicity in hepatocytes.
2026. jún. 24.· Molecular therapy. Nucleic acids· PUBMED
Publikáció
Analysis of PNPLA3, TM6SF2 and GCKR gene polymorphisms in patients with metabolic dysfunction-associated steatohepatitis treated with probiotics ‒ An exploratory study.
2026. jún. 16.· Nutricion hospitalaria· PUBMED
Publikáció
PNPLA3 polymorphisms and risk of hepatic and extrahepatic outcomes in MASLD: A meta-analysis of observational studies.
2026. jún. 6.· JHEP reports : innovation in hepatology· PUBMED
Publikáció
Association of Genetic Variants in PNPLA3, MBOAT7, and MARC1 with Metabolic and Hematological Immune-Inflammation Indices in Adolescent Females with and Without MASLD: A Multilevel Risk-Allele Burden Analysis.
2026. máj. 27.· International journal of molecular sciences· PUBMED
Publikáció
Consistent efficacy of efruxifermin across PNPLA3 genotypes in phase 2b trials in MASH.
2026. máj. 12.· Hepatology (Baltimore, Md.)· PUBMED
Publikáció
PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.
2026. máj. 10.· Scientific reports· PUBMED
Preprint
PNPLA3 I148M is a novel regulator of bone mass independent of MASLD.
2026. márc. 17.· bioRxiv : the preprint server for biology· PUBMED
Publikáció
HLA DRB1*01 and *04 Predisposition to Rheumatoid Arthritis and Polymorphisms of the SLCO1B1, MTHFR and PNPLA3 Genes Are Not Associated with Fatty Liver and Hepatotoxicity.
2026. febr. 16.· Journal of clinical medicine· PUBMED
Publikáció
Influence of genetics on clinical trajectories in children with MASLD: role of the PNPLA3 I148M polymorphism.
2026. febr. 7.· Journal of endocrinological investigation· PUBMED
Publikáció
The I148M PNPLA3 Variant Forces Progressive Portal MASLD by Spatially Perturbing Metabolic Pathways Across Liver Zones.
2026. febr. 6.· International journal of molecular sciences· PUBMED
Publikáció
A PNPLA3-NACC1-RIPK3 pathway mediates macrophage necroptosis and inflammation in MASLD.
2026. jan. 21.· Hepatology communications· PUBMED
Publikáció
PNPLA3 Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study.
2026. jan. 12.· Alimentary pharmacology & therapeutics· PUBMED
Publikáció
Reply: The PNPLA3 paradox-Does genotype modify the clinical utility of the MASLD framework in children?
2026. jan. 12.· Hepatology (Baltimore, Md.)· PUBMED
Publikáció
Letter to the Editor: The PNPLA3 paradox-Does genotype modify the clinical utility of the MASLD framework in children?
2026. jan. 9.· Hepatology (Baltimore, Md.)· PUBMED
Publikáció
Association of the Rs738409 Polymorphism in PNPLA3 with Development and Severity of Nonalcoholic Fatty Liver Disease.
2025. dec. 19.· Indian journal of endocrinology and metabolism· PUBMED
Publikáció
Integration of PNPLA3 and TM6SF2 genotypes provides incremental improvement in advanced fibrosis prediction among MASLD patients with type 2 diabetes mellitus.
2025. dec. 17.· JHEP reports : innovation in hepatology· PUBMED