ALS (motor neurone disease): trials for referral
256 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
Type a city to sort by distance. The distance is worked out in your browser; the city is not sent anywhere.
256 trials shown
No phase1 site
RecruitingUnited States
NCT05936619
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
Nader Pouratian
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 1/213 sites
RecruitingBelgium, Spain, United Kingdom, Netherlands, United States
NCT07287397
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Vector Y Therapeutics
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 13 sites
Not yet recruitingUnited States
NCT07906665
A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS)
Sachi Bioworks Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT03225144
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT05632757
Anticipated Patient and Caregiver Burden
Assistance Publique Hopitaux De Marseille
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govPhase 24 sites
By invitation onlyUnited States
NCT07688239
The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab
Tiziana Life Sciences LTD
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 26 sites
Not yet recruitingItaly
2026-526460-20-00
A RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER, CLINICAL TRIAL OF COLCHICINE IN AMYOTROPHIC LATERAL SCLEROSIS (CO-ALS II)
Azienda Ospedaliero Universitaria Di Modena
Registry updated 28 Oct 2026
Registry record: EU CTISNo phase1 site
RecruitingGermany
NCT07900672
Register for Medical Data, Functional Scales, and Care Outcomes in ALS, SMA, and Other Motor System Disorders
Ambulanzpartner Soziotechnologie APST GmbH
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07823101
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
Johns Hopkins University
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 356 sites
RecruitingBelgium, Canada, Germany, Spain, France, United Kingdom
NCT07322003
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Prilenia
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 1/22 sites
RecruitingUnited States
NCT07855211
A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)
Biogen
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.govNo phase7 sites
RecruitingFrance
NCT06083584
Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis Diagnosis
Centre Hospitalier Universitaire de Nīmes
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.govNo phase5 sites
RecruitingUnited States
NCT07543367
INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
Synchron, Inc.
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govPhase 14 sites
Not yet recruitingCanada, United States
NCT07883590
A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).
Eli Lilly and Company
Registry updated 20 Oct 2026
Registry record: ClinicalTrials.govPhase 23 sites
RecruitingGermany
2022-502743-35-00
Evaluation of the efficacy and safety of Rituximab in patients with Amyotrophic Lateral Sclerosis (ALS)
Deutsches Zentrum Fuer Neurodegenerative Erkrankungen e.V.
Registry updated 16 Oct 2026
Registry record: EU CTISNo phase1 site
RecruitingUnited States
NCT07871071
Brain-Computer Interface Communication Device for People With ALS
Cognixion
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govPhase 10 sites
Not yet recruiting
NCT07875972
Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS)
Liu Qing
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govPhase 1/26 sites
RecruitingGermany, United Kingdom, Netherlands
NCT07674667
FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS
Trace Neuroscience, Inc.
Registry updated 14 Oct 2026
Registry record: ClinicalTrials.govPhase 22 sites
RecruitingCanada
NCT06249867
A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS
Oliver Blanchard
Registry updated 9 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07521930
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
Johns Hopkins University
Registry updated 9 Oct 2026
Registry record: ClinicalTrials.govNo phase4 sites
Not yet recruitingItaly
NCT07865260
PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults
Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
Registry updated 8 Oct 2026
Registry record: ClinicalTrials.govNo phase7 sites
RecruitingUnited States
NCT07454733
Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Trustees of Dartmouth College
Registry updated 8 Oct 2026
Registry record: ClinicalTrials.govNo phase26 sites
RecruitingCanada, United States
NCT04363684
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Mayo Clinic
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.govPhase 2/320 sites
RecruitingAustralia, Italy
NCT06126315
Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS
Mario Negri Institute for Pharmacological Research
Registry updated 6 Oct 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingChina
NCT06726577
TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis
Talengen Institute of Life Sciences, Shenzhen, P.R. China.
Registry updated 2 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingUnited States
NCT07204977
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 1 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingUnited Kingdom
NCT07851714
Metabolism and Nutrition in MND
Guy's and St Thomas' NHS Foundation Trust
Registry updated 1 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT04394871
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 30 Sept 2026
Registry record: ClinicalTrials.govPhase 2/31 site
RecruitingUnited States
NCT04220190
RAPA-501 Therapy for ALS
Rapa Therapeutics LLC
Registry updated 29 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07844590
Developing New Ways to Detect Respiratory Impairment Early in ALS
Thomas Jefferson University
Registry updated 28 Sept 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States91 open trials
- Italy29 open trials
- France26 open trials
- China21 open trials
- Germany17 open trials
- Canada16 open trials
- Netherlands15 open trials
- Spain14 open trials
- Belgium14 open trials
- United Kingdom11 open trials
- Poland9 open trials
- Australia8 open trials
- Sweden7 open trials
- Israel6 open trials
- Denmark6 open trials
- Ireland5 open trials
- Norway4 open trials
- South Korea2 open trials
- Japan2 open trials
- Taiwan2 open trials
- Puerto Rico2 open trials
- Serbia2 open trials
- Czechia2 open trials
- United Arab Emirates2 open trials
- Slovenia2 open trials
- Portugal2 open trials
- Switzerland2 open trials
- Greece2 open trials
- Thailand2 open trials
- Brazil1 open trials
- Chile1 open trials
- Colombia1 open trials
- Ukraine1 open trials
- Russia1 open trials
- Hungary1 open trials
- Egypt1 open trials
- Mexico1 open trials
- Latvia1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
Turin, Italy
0 trials · 45 publications · ROR
Biomedical Research Networking Center on Neurodegenerative Diseases
Madrid, Spain
0 trials · 62 publications · ROR
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
0 trials · 34 publications · ROR
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
0 trials · 23 publications · ROR
National Hospital for Neurology and Neurosurgery
London, United Kingdom
1 trials · 58 publications · ROR
National Institute of Mental Health and Neurosciences
Bengaluru, India
0 trials · 25 publications · ROR
National Institute of Neurological Disorders and Stroke
Bethesda, United States
0 trials · 41 publications · ROR
Perron Institute for Neurological and Translational Science
Nedlands, Australia
0 trials · 34 publications · ROR
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
2 trials · 49 publications · ROR
University of Massachusetts Chan Medical School
Worcester, United States
2 trials · 57 publications · ROR
University of North Carolina at Chapel Hill
Chapel Hill, United States
1 trials · 23 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Phase changed: No phase → Phase 1
Quantification of Hsp90 in the Human Brain
NCT07380204 · Phase 1 · Belgium
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 5 Oct 2026
Completed31 participants
NCT03578796
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study
No phaseEnded 18 Aug 2026
Completed10 participants
NCT07491562
Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis
No phaseEnded 30 Jul 2026
Completed23 participants
NCT06119087
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study
Phase 1Ended 2 Jul 2026
No phaseEnded 25 Jun 2026
No phaseEnded 1 Jun 2026
No phaseEnded 29 May 2026
Phase 2Ended 13 May 2026
Completed41 participants
NCT07047209
Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS)
No phaseEnded 1 May 2026
Completed46 participants
NCT05829330
Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation
Phase 1Ended 31 Mar 2026
Completed8 participants
NCT05974579
Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Sclerosis
No phaseEnded 31 Mar 2026
Phase 2Ended 26 Feb 2026
Completed49 participants
NCT06441682
A safety and efficacy study of ARGX-119 in adult patients with Amyotrophic Lateral Sclerosis (ALS) (reALiSe)
No phaseEnded 31 Dec 2025
Phase 1/2Ended 16 Dec 2025
Completed1 participants
NCT07095712
Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS
Phase 3Ended 31 Oct 2025
Phase 1Ended 22 Aug 2025
Completed12 participants
2024-515021-29-00
A Randomized, Placebo-Controlled, Double-Blind, Single Dose, Phase 1 Study to Explore the PK/PD Relationship of QRL-101 in People Living With ALS
Phase 1Ended 22 Aug 2025
Completed12 participants
NCT06714396
A Study Exploring the PK/PD Relationship of QRL-101 in Adults With ALS
Phase 2Ended 13 Aug 2025
Completed73 participants
NCT05039099
A Study to Evaluate, Safety, Tolerability, and PK of AP-101 in Participants With ALS
Phase 1Ended 4 Aug 2025
No phaseEnded 30 Jun 2025
Completed500 participants
NCT02360891
Study of Predictive Factors of Progression of Motor Neurone Disease
Phase 1Ended 27 Jun 2025
Phase 2Ended 24 Jun 2025
Phase 1/2Ended 20 Jun 2025
Completed17 participants
NCT05189106
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
No phaseEnded 4 Jun 2025
Completed22 participants
NCT04691011
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis
No phaseEnded 1 Jun 2025
Completed42 participants
NCT03766321
Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients
Phase 2Ended 31 May 2025
Completed15 participants
NCT05163886
Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis
Phase 1Ended 30 May 2025
Completed12 participants
NCT06177431
An Open Label Extension Study of Monepantel in Individuals With Motor Neurone Disease
No phaseEnded 21 May 2025
Completed43 participants
NCT07625605
The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease
Phase 1Ended 15 May 2025
Completed24 participants
2024-518833-27-00
A Study Evaluating the Pharmacokinetics of Three QRL-101 Formulations in Healthy Participants
No phaseEnded 5 May 2025
Completed55 participants
NCT04468919
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
No phaseEnded 27 Apr 2025
Completed14 participants
NCT07656714
HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial
No phaseEnded 10 Apr 2025
Completed100 participants
NCT05595850
A Mindful Community for People With ALS and Their Primary Caregivers
No phaseEnded 4 Apr 2025
Completed95 participants
NCT04721717
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
No phaseEnded 31 Mar 2025
Completed5 participants
NCT05562960
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP
Phase 3Ended 26 Mar 2025
Phase 3Ended 18 Feb 2025
Completed130 participants
NCT03548311
Clinical Trial of Ultra-high Dose Methylcobalamin for ALS
- The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial. · JMIR research protocols, 2018
- Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. · JAMA neurology, 2022
Phase 4Ended 13 Feb 2025
Completed4 participants
NCT06849115
Effects of L-Carnitine in Amyotrophic Lateral Sclerosis Patients With CHCHD10 Mutations
No phaseEnded 12 Feb 2025
Completed81 participants
NCT04820478
Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS)
Phase 2Ended 20 Jan 2025
Completed51 participants
NCT05508074
Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol)
No phaseEnded 18 Jan 2025
Completed60 participants
NCT07260981
Comprehensive Biomarker Profiling of the IFN-α Pathway in Amyotrophic Lateral Sclerosis Patient Biofluids
Phase 3Ended 13 Jan 2025
Completed526 participants
NCT05021536
A study to investigate the safety and efficacy of AMX0035 in patients with Amyotrophic Lateral Sclerosis
No phaseEnded 1 Jan 2025
No phaseEnded 31 Dec 2024
Completed25000 participants
NCT05852418
Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases.
No phaseEnded 31 Dec 2024
Completed2000 participants
NCT05852405
Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS
No phaseEnded 18 Dec 2024
Completed230 participants
NCT02532244
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases
Phase 2Ended 26 Nov 2024
No phaseEnded 24 Nov 2024
Completed74 participants
NCT04259255
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)
Phase 3Ended 13 Nov 2024
Completed123 participants
NCT04745299
Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALS
Phase 2Ended 4 Nov 2024
No phaseEnded 1 Nov 2024
Completed13 participants
NCT05979688
Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis
Phase 3Ended 30 Oct 2024
Completed352 participants
NCT05619783
Extension Study Evaluating The Safety And Tolerability of AMX0035
Phase 2/3Ended 29 Oct 2024
No phaseEnded 28 Oct 2024
Completed45 participants
NCT05407428
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS Patients
Phase 2/3Ended 3 Oct 2024
Phase 1Ended 16 Sept 2024
Completed32 participants
2024-511405-27-00
A Multiple-Ascending-Dose Study of MK-1708 in Healthy Participants
No phaseEnded 5 Sept 2024
No phaseEnded 31 Aug 2024
No phaseEnded 28 Aug 2024
Completed80 participants
NCT05276349
Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS)
Phase 2Ended 23 Aug 2024
Completed8 participants
NCT05176093
A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis
Phase 3Ended 12 Aug 2024
Not medical advice. fetched 4 Nov 2026