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Sickle cell disease: trials for referral

218 open trials in the registries we read. Each row links to its registry record.

Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.

Sickle cell disease·What we know·Glossary

Where the open trials are

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Only trials with a pre-treatment window

218 trials shown

Phase 42 sites
RecruitingUnited States
NCT06665997
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
University of Pennsylvania
Registry updated 5 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
RecruitingUnited States
NCT05904093
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
Registry updated 5 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
Not yet recruitingUnited States
NCT07799571
Buprenorphine for the Management of Pain in Children With Sickle Cell Disease
Natasha Archer
Registry updated 4 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 240 sites
RecruitingBelgium, France, United Kingdom, Italy, Netherlands, United States
NCT07224360
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
CSL Behring
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 10 sites
Not yet recruiting
NCT05605366
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
University of Cincinnati
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 24 sites
RecruitingCanada
NCT07282210
Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype
Biossil Inc.
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
No phase1 site
Not yet recruitingUnited States
NCT07910396
Focused Ultrasound Neuromodulation for Chronic Pain
University of Minnesota
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
No phase5 sites
Not yet recruitingUnited States
NCT06743113
Hypoxic Red Blood Cells in Sickle Cell Anemia
Hemanext
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 318 sites
RecruitingBelgium, France, Ireland, Italy, United States
NCT07656415
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
Agios Pharmaceuticals, Inc.
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 423 sites
By invitation onlyBelgium, Brazil, Canada, France, United Kingdom, Israel
NCT05777993
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
Agios Pharmaceuticals, Inc.
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 1/213 sites
RecruitingBrazil, United States
NCT06546670
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Novartis Pharmaceuticals
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 1/21 site
RecruitingUnited States
NCT04008368
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
National Heart, Lung, and Blood Institute (NHLBI)
Registry updated 26 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 21 site
RecruitingUnited States
NCT04099966
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Mitchell Cairo
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
No phase1 site
RecruitingUnited States
NCT07090668
Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
Emory University
Registry updated 22 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
RecruitingUnited States
NCT07708350
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease
Daniel Bauer
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
RecruitingUnited States
NCT07566494
Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 1/23 sites
RecruitingUnited States
NCT04774536
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Mark Walters, MD
Registry updated 20 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
No phase1 site
RecruitingUnited States
NCT07674277
Virtual Reality for SCD VOC
University of Maryland, Baltimore
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 363 sites
RecruitingBelgium, Brazil, Germany, Spain, France, United Kingdom
NCT06975865
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Sanofi
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
No phase2 sites
Not yet recruitingUnited States
NCT07875777
Self-administered Acupressure in Patients With Sickle Cell Disease
University of Cincinnati
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
RecruitingUnited States
NCT06506461
Gene Editing For Sickle Cell Disease
St. Jude Children's Research Hospital
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 333 sites
RecruitingBrazil, Colombia, Kenya, Uganda, United States
NCT06439082
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Novartis Pharmaceuticals
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 1/21 site
RecruitingUnited States
NCT07599176
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
National Heart, Lung, and Blood Institute (NHLBI)
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 258 sites
RecruitingBelgium, Germany, Spain, France, United Kingdom, Greece
NCT06699849
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
CSL Behring
Registry updated 8 Oct 2026 · The registries disagree on the status
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 111 sites
RecruitingUnited States
NCT07187973
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
Disc Medicine, Inc
Registry updated 5 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 27 sites
RecruitingFrance, French Guiana
NCT06578507
Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Disease
Theravia
Registry updated 1 Oct 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 11 site
RecruitingUnited States
NCT04055818
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
EpiDestiny, Inc.
Registry updated 30 Sept 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Early Phase 11 site
RecruitingUnited States
NCT06313398
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
National Heart, Lung, and Blood Institute (NHLBI)
Registry updated 28 Sept 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 40 sites
Not yet recruiting
NCT07826988
Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis
Assistance Publique - Hôpitaux de Paris
Registry updated 18 Sept 2026
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site
Phase 3101 sites
RecruitingCanada, Germany, Egypt, Spain, France, United Kingdom
NCT06609226
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Novo Nordisk A/S
Registry updated 18 Sept 2026 · The registries disagree on the status
Registry record: ClinicalTrials.gov
Compare criteriaReferral pack Letter to the site

389 sites Pre-treatment window

The same sites as a list

Who treats this

Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.

Ahmadu Bello University Teaching Hospital
Zaria, Nigeria
3 trials · 23 publications · ROR
All India Institute of Medical Sciences
New Delhi, India
3 trials · 22 publications · ROR
All India Institute of Medical Sciences Raipur
Raipur, India
5 trials · 25 publications · ROR
Aminu Kano Teaching Hospital
Kano, Nigeria
14 trials · 27 publications · ROR
Amsterdam University Medical Centers
Amsterdam, Netherlands
10 trials · 56 publications · ROR
Assistance Publique – Hôpitaux de Paris
Paris, France
15 trials · 159 publications · ROR
Augusta University
Augusta, United States
5 trials · 47 publications · ROR
Baylor College of Medicine
Houston, United States
6 trials · 79 publications · ROR
Bicêtre Hospital
Le Kremlin-Bicêtre, France
3 trials · 23 publications · ROR
Boston Children's Hospital
Boston, United States
19 trials · 74 publications · ROR
Boston Medical Center
Boston, United States
10 trials · 31 publications · ROR
Brigham and Women's Hospital
Boston, United States
1 trial · 38 publications · ROR
Centre Hospitalier de l’Université de Montréal
Montreal, Canada
2 trials · 27 publications · ROR
Centre Hospitalier Universitaire Henri-Mondor
Créteil, France
1 trial · 57 publications · ROR
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Canada
3 trials · 24 publications · ROR
Children's Healthcare of Atlanta
Atlanta, United States
25 trials · 138 publications · ROR
Children’s Hospital at TriStar Centennial
Nashville, United States
2 trials · 23 publications · ROR
Children's Hospital Colorado
Aurora, United States
4 trials · 22 publications · ROR
Children's Hospital Los Angeles
Los Angeles, United States
7 trials · 22 publications · ROR
Children's Hospital of Philadelphia
Philadelphia, United States
21 trials · 129 publications · ROR
Children's National
Washington, United States
20 trials · 92 publications · ROR
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
13 trials · 131 publications · ROR
Cleveland Clinic
Cleveland, United States
4 trials · 39 publications · ROR
Columbia University
New York, United States
1 trial · 30 publications · ROR
Columbia University Irving Medical Center
New York, United States
16 trials · 54 publications · ROR
Dana-Farber Cancer Institute
Boston, United States
5 trials · 59 publications · ROR
Duke Medical Center
Durham, United States
19 trials · 73 publications · ROR
Duke University
Durham, United States
10 trials · 123 publications · ROR
Emory University
Atlanta, United States
12 trials · 255 publications · ROR
Erasmus MC
Rotterdam, Netherlands
5 trials · 31 publications · ROR

What changed in the last 7 days

RSS feed (30 days)Calendar reminder

Registry facts, one per line, newest first.

5 Nov 2026
Paused
Safety and Efficacy of KL003 Cell Injection in Severe Sickle Cell Disease
NCT07436767 · No phase · China
Source: ClinicalTrials.gov
28 Oct 2026
Opened for recruitment
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
NCT07656415 · Phase 3 · Belgium, France, Ireland, Italy, United States
Source: ClinicalTrials.gov
8 Oct 2026
Phase changed: Phase 2/3 → Phase 2
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
NCT06699849 · Phase 2 · Belgium, Germany, Spain, France, United Kingdom, Greece
Source: ClinicalTrials.gov
8 Oct 2026
Opened for recruitment
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
NCT06699849 · Phase 2 · Belgium, Germany, Spain, France, United Kingdom, Greece
Source: ClinicalTrials.gov
18 Sept 2026
Opened for recruitment
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
NCT06609226 · Phase 3 · Canada, Germany, Egypt, Spain, France, United Kingdom
Source: ClinicalTrials.gov
18 Sept 2026
Phase changed: Phase 1/2 → Phase 2
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
NCT06198712 · Phase 2 · Canada, France, United Kingdom, Kenya, Lebanon, Nigeria
Source: ClinicalTrials.gov
1 Jul 2026
Closed for recruitment
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649 · Phase 3 · Germany, United Kingdom, Italy, United States
Source: ClinicalTrials.gov
8 Jun 2026
Opened for recruitment
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
NCT04657822 · Phase 4 · Belgium, Brazil, Colombia, Germany, Spain, France
Source: ClinicalTrials.gov
6 Apr 2026
Phase changed: Phase 2/3 → Phase 3
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659 · Phase 3 · Canada, Germany, Egypt, Spain, France, United Kingdom
Source: ClinicalTrials.gov
20 Mar 2025
Status changed: Recruiting → By invitation only
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
NCT04628585 · Phase 3 · France, United States
Source: ClinicalTrials.gov
11 Aug 2026
Status changed: Recruiting → By invitation only
A Long-term Follow-up Study in Participants Who Received CTX001
NCT04208529 · Phase 3 · Belgium, Canada, Germany, United Kingdom, Italy, United States
Source: ClinicalTrials.gov
16 Sept 2026
Phase changed: Phase 1/2 → Phase 2/3
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease
NCT03745287 · Phase 2/3 · Belgium, Canada, Germany, France, United Kingdom, Italy
Source: ClinicalTrials.gov
14 Oct 2026
Status changed: Completed → Running, not recruiting
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
NCT03814746 · Phase 3 · Belgium, Brazil, Canada, Colombia, Germany, Spain
Source: ClinicalTrials.gov
19 Nov 2025
Closed for recruitment
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
NCT06699849 · Phase 2 · Belgium, Germany, Spain, France, United Kingdom, Greece
Source: ClinicalTrials.gov
30 Oct 2026
Closed for recruitment
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
NCT04657822 · Phase 4 · Belgium, Brazil, Colombia, Germany, Spain, France
Source: ClinicalTrials.gov
10 Aug 2026
Closed for recruitment
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
NCT06609226 · Phase 3 · Canada, Germany, Egypt, Spain, France, United Kingdom
Source: ClinicalTrials.gov
16 Jun 2026
Opened for recruitment
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)
NCT05329649 · Phase 3 · Germany, United Kingdom, Italy, United States
Source: ClinicalTrials.gov
2 Nov 2026
Status changed: Recruiting → Not yet recruiting
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
NCT07656415 · Phase 3 · Belgium, France, Ireland, Italy, United States
Source: ClinicalTrials.gov
20 Mar 2025
Phase changed: No phase → Phase 3
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
NCT04628585 · Phase 3 · France, United States
Source: ClinicalTrials.gov

Results card

Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.

No phaseEnded 31 Oct 2026
Paused3 participants
NCT05457790
Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)
Reason given: Study on hold pending consideration for amendment.
Registry record
No phaseEnded 1 Oct 2026
Completed34 participants
NCT07877753
Evolution of Sickle Cell Maculopathy
Registry record
No phaseEnded Sept 2026
Completed70 participants
NCT02785848
Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text Messaging
Registry record
No phaseEnded 23 Jul 2026
Completed60 participants
NCT06264700
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
Registry record
No phaseEnded 9 Jul 2026
Completed37 participants
NCT06886477
Sickle Cell, Pain and Mediterranean Diet
Registry record
Phase 2Ended 2 Jul 2026
Stopped early1 participant
NCT07401823
Open-Label Extension Study to Pioneer Study 6058-SCD-101
Reason given: Sponsor Decision
Registry record
Phase 2Ended 30 Jun 2026
Completed13 participants
NCT06144749
A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)
Registry record
Phase 1Ended 1 Jun 2026
Stopped early13 participants
NCT07431398
Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell Disease
Reason given: Sponsor decision
Registry record
Phase 2Ended 28 May 2026
Completed14 participants
NCT05012631
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease
Registry record
No phaseEnded 8 May 2026
Completed25 participants
NCT07402811
Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease
Registry record
No phaseEnded 6 May 2026
Completed27 participants
NCT06880679
Ultrasound Acute Chest Syndrome Sickle Cell Disease
Registry record
Phase 2Ended 9 Apr 2026
Completed95 participants
NCT05075824
A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)
Registry record
Phase 1Ended 31 Mar 2026
Completed15 participants
NCT04925492
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
Registry record
No phaseEnded 13 Mar 2026
Completed239 participants
NCT04484272
A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease
Registry record
No phaseEnded 12 Mar 2026
Completed146 participants
NCT06397118
Prevention of Malnutrition in Children With Sickle Cell Disease
Registry record
Phase 2Ended 9 Mar 2026
Completed12 participants
NCT05725902
Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Disease
Registry record
Phase 2Ended 5 Mar 2026
Completed6 participants
NCT06023199
Assessing Physical Function in Sickle Cell Patients Taking Voxelotor
Registry record
No phaseEnded 1 Mar 2026
Completed24 participants
NCT05087303
Telemedicine for Children With Sickle Cell Disease
Registry record
Phase 2Ended 28 Feb 2026
Completed379 participants
NCT04906447
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain
- Depression, pain, and catastrophizing in adults with sickle cell disease and chronic pain. · General hospital psychiatry, 2026
Registry record
Phase 2Ended 12 Feb 2026
Completed17 participants
NCT06286046
A Clinical Study of Mitapivat in Patients with Sickle Cell Disease and Kidney Disease
Registry record

Show more

Phase 2Ended 11 Feb 2026
Completed35 participants
NCT05861453
Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients With Sickle Cell Disease
Registry record
Phase 1Ended 20 Jan 2026
Completed45 participants
NCT05169580
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir
Registry record
No phaseEnded 31 Dec 2025
Completed30486 participants
NCT07532564
Risk Factors, Costs, and Impacts of ED Boarding
Registry record
No phaseEnded 30 Dec 2025
Completed50 participants
NCT06939933
Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia
Registry record
Phase 1/2Ended 11 Dec 2025
Stopped early1 participant
NCT06078696
Siplizumab for Sickle Cell Disease Transplant
Reason given: Closed by the industry collaborator
Registry record
No phaseEnded 2 Dec 2025
Completed93 participants
NCT07721155
Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking
Registry record
Phase 1Ended 21 Nov 2025
Completed10 participants
NCT05378555
Oral Ketamine for Treatment of Vaso-Occlusive Pain
Registry record
Phase 3Ended 7 Nov 2025
Stopped early242 participants
NCT05348915
A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease
Reason given: Sponsor decision to terminate study based on results of parent study GBT2104-131.
Registry record
Phase 2/3Ended 7 Nov 2025
Completed100 participants
NCT06561061
Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2)
- Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia: The ZIPS-2 Randomized Clinical Trial. · JAMA, 2026
Registry record
No phaseEnded 1 Oct 2025
Completed8 participants
NCT04523376
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies
Registry record
No phaseEnded 30 Sept 2025
Completed8400 participants
NCT07305181
Prevalence of Abnormal Haemoglobin Variants in Metropolitan Chattogram, Bangladesh
Registry record
Phase 1/2Ended 24 Sept 2025
Completed4 participants
NCT02247843
Stem Cell Gene Therapy for Sickle Cell Disease
- Clinical outcomes of lentiviral vector gene therapy for sickle cell disease. · Blood advances, 2026
Registry record
Phase 2Ended 24 Sept 2025
Completed53 participants
NCT04987489
A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease
Registry record
Phase 1Ended 22 Sept 2025
Stopped early11 participants
NCT05660265
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years
Reason given: Sponsor decision to terminate the study due to strategic business consideration and not related to safety.
Registry record
No phaseEnded 16 Sept 2025
Completed36 participants
NCT04688411
An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease
Registry record
Phase 1Ended 15 Aug 2025
Completed30 participants
NCT04912869
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD).
Registry record
No phaseEnded 8 Aug 2025
Completed33 participants
NCT05714098
Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)
- The SickleFit Tele-Exercise Program for older adults with sickle cell disease: feasibility, acceptability, safety study. · Blood red cells & iron, 2026
Registry record
No phaseEnded 31 Jul 2025
Completed30 participants
NCT06251843
Support Strategies for Parents During the First Year Following Their Child's Diagnosis of Sickle Cell Disorder
Registry record
No phaseEnded Jul 2025
Completed10 participants
NCT01758042
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
Registry record
Phase 2Ended 24 Jul 2025
Completed96 participants
NCT05405114
Research Study Investigating How Well NDec Works in People With Sickle Cell Disease
Registry record
Phase 1/2Ended 17 Jul 2025
Completed7 participants
NCT03653247
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease
Registry record
Phase 2/3Ended 7 Jul 2025
Completed63 participants
NCT03745287
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease
Registry record
No phaseEnded 30 Jun 2025
Completed13 participants
NCT07554547
Crizanlizumab Pregnancy Outcomes Intensive Monitoring
Registry record
No phaseEnded 30 Jun 2025
Completed40 participants
NCT06580067
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
Registry record
No phaseEnded 30 Jun 2025
Completed120 participants
NCT04380610
Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
Registry record
No phaseEnded 30 Jun 2025
Completed18 participants
NCT04109820
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
Registry record
Phase 1Ended 24 Jun 2025
Completed10 participants
NCT05618301
Motixafortide and Natalizumab to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD)
Registry record
No phaseEnded 17 Jun 2025
Completed52 participants
NCT06345638
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
Registry record
No phaseEnded 5 Jun 2025
Completed8 participants
NCT03412045
Hyperbaric Oxygen Therapy in Sickle Cell Pain
Registry record
No phaseEnded 2 Jun 2025
Completed6824 participants
NCT05687474
Baby Detect : Genomic Newborn Screening
Registry record
No phaseEnded 29 May 2025
Completed68 participants
NCT04691323
The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.
Registry record
No phaseEnded 26 May 2025
Completed257 participants
NCT06650059
Cohort Study of Sickle Cell Patients Evaluating Analgesic Strategies and Their Consequences
Registry record
Phase 1Ended 30 Apr 2025
Completed22 participants
NCT04426591
Biotin-RBC Transfusion in SCD
- Red blood cell transfusion survival in sickle cell disease is reduced by donor characteristics and recipient spleen activity. · Blood advances, 2026
Registry record
No phaseEnded 30 Mar 2025
Completed170 participants
NCT07066072
The Radiofrequency Therapy in Management of Sickle Cell Disease Chronic Pain RCT Tested the Effect of TECAR Therapy on Sickle Cell Disease Chronic Pain.
Registry record
Phase 1Ended 27 Mar 2025
Completed25 participants
NCT02193191
Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease
Registry record
Phase 3Ended 19 Mar 2025
Completed104 participants
NCT03789591
Hydroxyurea Optimization Through Precision Study
Registry record
No phaseEnded 19 Mar 2025
Completed1063 participants
NCT06835335
Opioid Prescribing in the Emergency Department for Sickle Cell Disease
- Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians. · BMJ open, 2025
Registry record
No phaseEnded 17 Mar 2025
Completed72 participants
NCT04754711
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition
Registry record
Phase 3Ended 10 Mar 2025
Completed270 participants
NCT04750707
Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )
Registry record
Phase 1/2Ended 27 Feb 2025
Completed17 participants
NCT05451940
Hydroxyurea and EPO in Sickle Cell Disease
Registry record

Not medical advice. fetched 8 Nov 2026

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