ALS (motor neurone disease) trials in United States

In United States 90 Also abroad 225

90 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Where
Bethesda
Age
18 years to 110 years
People
360
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT03225144
No phaseEnrolling by invitation
Rehabilitation and Exercise in SOD1-ALS TOfersen REcipients (RESTORE)
Where
St Louis
Age
18 years and over
People
10
Run by
Washington University School of Medicine
See details and how to joinNCT05725759
Phase 1/2Taking people
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Where
Boston, Jacksonville, New York, Philadelphia, Phoenix, San Diego
Age
18 years and over
People
36 worldwide
Run by
Vector Y Therapeutics
See details and how to joinNCT07287397 · EU 2025-522697-37-00
No phaseTaking people
Clinical Outcome Assessment for AT & BCI
Where
Chicago
Age
18 years and over
People
60
Run by
Shirley Ryan AbilityLab
See details and how to joinNCT07407725
No phaseTaking people
ASSESS ALL ALS Study
Where
Ann Arbor, Aurora, Baltimore, Bethseda, Birmingham, Boise, Boston, Chicago, Colombus, Dallas, Davie, Detroit, Durham, Hershey, Indianapolis, Irvine, Jacksonville, La Jolla, Lebanon, Los Angeles, Minneapolis, Nashville, New Britain, New York, Omaha, Philadelphia, Phoenix, Portland, Richmond, Salt Lake City, San Francisco, Seattle, St Louis, Washington D.C.
Age
18 years and over
People
2,000 worldwide
Run by
St. Joseph's Hospital and Medical Center, Phoenix
See details and how to joinNCT06578195
Phase 1Not yet taking people in United States
Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS
Where
Durham, Philadelphia
Age
18 years and over
People
100
Run by
Duke University
See details and how to joinNCT07589764
No phaseTaking people
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
Where
Dallas
Age
18 years to 65 years
People
2
Run by
Nader Pouratian
See details and how to joinNCT05936619
Phase 1Not yet taking people in United States
A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS)
Where
Jacksonville, Rochester, Scottsdale
Age
18 years and over
People
40
Run by
Sachi Bioworks Inc.
See details and how to joinNCT07906665
Phase 2Enrolling by invitation
The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab
Where
Boston, Chicago, Davie, Minneapolis
Age
18 years to 75 years
People
44
Run by
Tiziana Life Sciences LTD
See details and how to joinNCT07688239
No phaseTaking people
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
Where
Baltimore
Age
18 years and over
People
30
Run by
Johns Hopkins University
See details and how to joinNCT07823101
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Where
Atlanta, Aurora, Baltimore, Boston, Chicago, Dallas, Fairway, Houston, Jacksonville, Lincoln, New York, Philadelphia, Phoenix, San Francisco, Seattle, St Louis, Tampa
Age
18 years to 80 years
People
500 worldwide
Run by
Prilenia
See details and how to joinNCT07322003
Phase 1/2Taking people
A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)
Where
Austin, St Louis
Age
18 years and over
People
69
Run by
Biogen
See details and how to joinNCT07855211
Phase 1Not yet taking people in United States
A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).
Where
Aurora, Kansas City, San Francisco
Age
18 years to 75 years
People
32 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07883590
No phaseTaking people
Brain-Computer Interface Communication Device for People With ALS
Where
Santa Barbara
Age
18 years and over
People
30
Run by
Cognixion
See details and how to joinNCT07871071
No phaseTaking people
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
Where
Baltimore
Age
18 years to 80 years
People
5
Run by
Johns Hopkins University
See details and how to joinNCT07521930
No phaseTaking people
Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Where
Boston, Hershey, Jacksonville, Lebanon, Madison, Pittsburgh, Scottsdale
Age
18 years and over
People
800
Run by
Trustees of Dartmouth College
See details and how to joinNCT07454733
No phaseTaking people
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Where
Ann Arbor, Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chapel Hill, Chicago, Cleveland, Denver, Houston, Indianapolis, Jacksonville, Los Angeles, Nashville, New York, Philadelphia, Rochester, San Antonio, San Diego, San Francisco, Seattle, St Louis
Age
18 years and over
People
2,100 worldwide
Run by
Mayo Clinic
See details and how to joinNCT04363684
Phase 1Taking people
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
Where
Bethesda
Age
18 years to 99 years
People
30
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT07204977
No phaseTaking people
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
Where
Bethesda
Age
5 years to 120 years
People
330
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT04394871
Phase 2/3Taking people
RAPA-501 Therapy for ALS
Where
Boston
Age
18 years and over
People
41
Run by
Rapa Therapeutics LLC
See details and how to joinNCT04220190
No phaseTaking people
Developing New Ways to Detect Respiratory Impairment Early in ALS
Where
Philadelphia
Age
18 years and over
People
70
Run by
Thomas Jefferson University
See details and how to joinNCT07844590
Phase 1Not yet taking people in United States
Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS)
Where
Boston
Age
18 years to 70 years
People
10
Run by
Mark Poznansky
See details and how to joinNCT07838389
Phase 1Taking people
A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Where
Baltimore, Columbia, Columbus, La Jolla, Palo Alto, Philadelphia, Worcester
Age
18 years to 79 years
People
23
Run by
Insmed Gene Therapy LLC
See details and how to joinNCT07290062
No phaseTaking people
Using Gaze to Enable Head-neck Movements in Patients With Head Drop
Where
Salt Lake City
Age
18 years and over
People
12
Run by
University of Utah
See details and how to joinNCT07836751
Phase 2Taking people
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Austin, Birmingham, Boston, Buffalo, Chapel Hill, Charlottesville, Chicago, Cleveland, Columbus, Draper, Honolulu, Kansas City, Knoxville, Madison, New York, Novi, Omaha, Philadelphia, Rockville, San Diego, Santa Rosa, Seattle, Shreveport, Tampa, Towson, Tucson, Worcester
Age
18 years to 80 years
People
100
Run by
Reunion Neuroscience Inc
See details and how to joinNCT07002034