ALS (motor neurone disease) trials in United States

In United States 91 Also abroad 226

31 of 91 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Where
Bethesda
Age
18 years to 110 years
People
360
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT03225144
No phaseEnrolling by invitation
Rehabilitation and Exercise in SOD1-ALS TOfersen REcipients (RESTORE)
Where
St Louis
Age
18 years and over
People
10
Run by
Washington University School of Medicine
See details and how to joinNCT05725759
No phaseTaking people
ASSESS ALL ALS Study
Where
Ann Arbor, Aurora, Baltimore, Bethseda, Birmingham, Boise, Boston, Chicago, Colombus, Dallas, Davie, Detroit, Durham, Hershey, Indianapolis, Irvine, Jacksonville, La Jolla, Lebanon, Los Angeles, Minneapolis, Nashville, New Britain, New York, Omaha, Philadelphia, Phoenix, Portland, Richmond, Salt Lake City, San Francisco, Seattle, St Louis, Washington D.C.
Age
18 years and over
People
2,000 worldwide
Run by
St. Joseph's Hospital and Medical Center, Phoenix
See details and how to joinNCT06578195
No phaseTaking people
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
Where
Baltimore
Age
18 years and over
People
30
Run by
Johns Hopkins University
See details and how to joinNCT07823101
No phaseTaking people
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Where
Ann Arbor, Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chapel Hill, Chicago, Cleveland, Denver, Houston, Indianapolis, Jacksonville, Los Angeles, Nashville, New York, Philadelphia, Rochester, San Antonio, San Diego, San Francisco, Seattle, St Louis
Age
18 years and over
People
2,100 worldwide
Run by
Mayo Clinic
See details and how to joinNCT04363684
No phaseTaking people
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
Where
Bethesda
Age
5 years to 120 years
People
330
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT04394871
No phaseTaking people
Developing New Ways to Detect Respiratory Impairment Early in ALS
Where
Philadelphia
Age
18 years and over
People
70
Run by
Thomas Jefferson University
See details and how to joinNCT07844590
No phaseTaking people
Biofluid Research on Age-Related or Inherited Neurodegeneration
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT07798700
No phaseTaking people
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
Where
Jacksonville
Age
18 years and over
People
3,000
Run by
Mayo Clinic
See details and how to joinNCT05474235
No phaseNot yet taking people in United States
Digital Speech Markers for Monitoring ALS in Spanish Speakers
Where
Fort Lauderdale
Age
18 years to 90 years
People
35
Run by
Nova Southeastern University
See details and how to joinNCT07341334
No phaseTaking people
Multicenter ALS Imaging Study
Where
Evanston, Gainesville, Minneapolis
Age
18 years and over
People
90
Run by
University of Minnesota
See details and how to joinNCT06735014
No phaseTaking people
Analysis of Human ALS Tissues and Registry of ALS Patients
Where
Chicago
Age
18 years to 90 years
People
40
Run by
University of Illinois Chicago
See details and how to joinNCT05067179
No phaseTaking people
Healing ALS Registry Observational Study (HAROS)
Where
Park City
Age
18 years to 110 years
People
1,000
Run by
Healing Advocates Registry and Ministry
See details and how to joinNCT07233148
No phaseTaking people
Clinical Procedures to Support Research in ALS
Where
Durham, Irvine, Kansas City, Miami, Minneapolis, New York, Palo Alto, Portland, San Antonio, San Francisco, Winston-Salem
Age
18 years and over
People
1,200
Run by
University of Miami
See details and how to joinNCT03489278
No phaseTaking people
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
Where
Loma Linda
Age
18 years to 85 years
People
160
Run by
Loma Linda University
See details and how to joinNCT04097158
No phaseTaking people
ALS/MND Natural History Study Data Repository
Where
Burlington, Chicago, Detroit, Gainesville, Grand Rapids, Loma Linda, Los Angeles, Minneapolis, Philadelphia, Pittsburgh, Portland, Richmond, St Louis
Age
18 years to 90 years
People
5,000 worldwide
Run by
Massachusetts General Hospital
See details and how to joinNCT05966038
No phaseTaking people
The National Amyotrophic Lateral Sclerosis Registry
Where
Atlanta
Age
18 years and over
People
30,000
Run by
Centers for Disease Control and Prevention
See details and how to joinNCT01772602
No phaseTaking people
EIM Via the Myolex mScan as an ALS Biomarker
Where
Ann Arbor, Boston, Lebanon, Phoenix, Winston-Salem
Age
18 years and over
People
80
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT06491732
No phaseTaking people
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
Where
Boston
Age
18 years and over
People
125
Run by
Biogen
See details and how to joinNCT07259980
No phaseTaking people
Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
Where
Salisbury
Age
18 years and over
People
30
Run by
TidalHealth, Inc.
See details and how to joinNCT07491484
No phaseTaking people
Clinical Research in ALS Study
Where
Miami
Age
18 years and over
People
10,000
Run by
University of Miami
See details and how to joinNCT00136500
No phaseTaking people
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Where
Miami
Age
18 years and over
People
500
Run by
University of Miami
See details and how to joinNCT00317616
No phaseTaking people
Intermuscular Coherence as a Biomarker for ALS
Where
Boston, Irvine, Miami, St Louis
Age
20 years to 90 years
People
650
Run by
University of Chicago
See details and how to joinNCT05104710
No phaseTaking people
Retinal Imaging in Neurodegenerative Disease
Where
Durham
Age
18 years and over
People
2,000
Run by
Duke University
See details and how to joinNCT03233646
No phaseTaking people
UPenn Observational Research Repository on Neurodegenerative Disease
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT04715399