ALS (motor neurone disease) trials in United States

In United States 91 Also abroad 226

91 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Developing New Ways to Detect Respiratory Impairment Early in ALS
Where
Philadelphia
Age
18 years and over
People
70
Run by
Thomas Jefferson University
See details and how to joinNCT07844590
Phase 1Not yet taking people in United States
Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS)
Where
Boston
Age
18 years to 70 years
People
10
Run by
Mark Poznansky
See details and how to joinNCT07838389
No phaseTaking people
Using Gaze to Enable Head-neck Movements in Patients With Head Drop
Where
Salt Lake City
Age
18 years and over
People
12
Run by
University of Utah
See details and how to joinNCT07836751
No phaseTaking people
Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study
Where
Boston
Age
18 years to 80 years
People
15
Run by
PathMaker Neurosystems Inc.
See details and how to joinNCT06649955
Early phase 1Taking people
Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
Where
Iowa City
Age
18 years to 80 years
People
20
Run by
University of Iowa
See details and how to joinNCT07224269
Phase 2Taking people
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Where
Atlanta, Boston, Dallas, Detroit, Houston, La Jolla, Lincoln, New Britain, Orange, Pittsburgh, Richmond, San Francisco, Seattle, Tampa, Winston-Salem
Age
18 years and over
People
240 worldwide
Run by
Zydus Therapeutics Inc.
See details and how to joinNCT07023835 · EU 2025-522580-15-00
No phaseTaking people
Biofluid Research on Age-Related or Inherited Neurodegeneration
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT07798700
No phaseTaking people
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
Where
Jacksonville
Age
18 years and over
People
3,000
Run by
Mayo Clinic
See details and how to joinNCT05474235
No phaseTaking people
Investigation on the Cortical Communication (CortiCom) System
Where
Baltimore
Age
22 years to 70 years
People
3
Run by
Johns Hopkins University
See details and how to joinNCT03567213
No phaseTaking people
Tongue-strengthening Exercises in People With ALS.
Where
Davie
Age
18 years to 99 years
People
20
Run by
Nova Southeastern University
See details and how to joinNCT07295990
Early phase 1Taking people
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Where
Baltimore
Age
18 years and over
People
24
Run by
Johns Hopkins University
See details and how to joinNCT06656702
No phaseTaking people
Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications
Where
University Park
Age
18 years to 90 years
People
300
Run by
Penn State University
See details and how to joinNCT06266403
No phaseTaking people
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
Where
Fort Lauderdale
Age
18 years and over
People
22
Run by
Andrea Charvet
See details and how to joinNCT06609213
No phaseNot yet taking people in United States
Digital Speech Markers for Monitoring ALS in Spanish Speakers
Where
Fort Lauderdale
Age
18 years to 90 years
People
35
Run by
Nova Southeastern University
See details and how to joinNCT07341334
Phase 1/2Enrolling by invitation
Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS
Where
New York, St Louis
People
6
Run by
n-Lorem Foundation
See details and how to joinNCT07743268
No phaseTaking people
Multicenter ALS Imaging Study
Where
Evanston, Gainesville, Minneapolis
Age
18 years and over
People
90
Run by
University of Minnesota
See details and how to joinNCT06735014
Phase 1Not yet taking people in United States
Safety Study of XT-150 in Participants With ALS
Where
Baltimore, Boston, Detroit, Phoenix
Age
18 years to 80 years
People
8
Run by
Xalud Therapeutics, Inc.
See details and how to joinNCT06704347
No phaseNot yet taking people in United States
iBCI Optimization for Veterans With Paralysis
Where
Providence
Age
18 years to 80 years
People
2
Run by
VA Office of Research and Development
See details and how to joinNCT05470478
Phase 2Taking people
PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS
Where
Jacksonville, La Jolla, New York, San Francisco, Scottsdale
Age
18 years to 75 years
People
105 worldwide
Run by
PhenoNet, Inc.
See details and how to joinNCT07142291
Phase 1/2Enrolling by invitation
Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS
Where
Philadelphia
People
1
Run by
n-Lorem Foundation
See details and how to joinNCT07703462
Phase 1/2Enrolling by invitation
Personalized Antisense Oligonucleotide for Participants With CHCHD10 ALS
Where
New York
Age
18 years and over
People
9
Run by
n-Lorem Foundation
See details and how to joinNCT07095686
No phaseTaking people
Analysis of Human ALS Tissues and Registry of ALS Patients
Where
Chicago
Age
18 years to 90 years
People
40
Run by
University of Illinois Chicago
See details and how to joinNCT05067179
Phase 1/2Taking people
Intestinal Microbiome Transplant in ALS
Where
Durham
Age
18 years and over
People
20
Run by
Duke University
See details and how to joinNCT07017946
No phaseTaking people
Neurologic Stem Cell Treatment Study
Where
Coral Springs, Westport
Age
18 years and over
People
500 worldwide
Run by
MD Stem Cells
See details and how to joinNCT02795052
Phase 2Taking people
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Where
Hershey, Philadelphi, Philadelphia
Age
18 years and over
People
48
Run by
University of Pennsylvania
See details and how to joinNCT07071935