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ALS (motor neurone disease): open trials in United States

61 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT07287397

    Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

    Trial Treatment · Phase 1/2 · Vector Y Therapeutics

    Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, Boston · Mayo Clinic in Florida, Jacksonville · University of Miami School of Science, Miami · Herbert Irving Comprehensive Cancer Center, New York · University of Pennsylvania, Philadelphia · St. Joseph's Hospital and Medical Center/Barrow Neurological Institute, Phoenix · University of California San Diego Medical Center, San Diego

    Registry updated 2026-10-30

  • NCT07688239

    The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab

    Trial Treatment · Phase 2 · Tiziana Life Sciences LTD

    Massachusetts General Hospital, Boston · Northwestern University, Chicago · Nova Southeastern University, Davie · University of Minnesota, Minneapolis

    Registry updated 2026-10-28

  • NCT07823101

    Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis

    Research · Johns Hopkins University

    The Johns Hopkins Hospital, Baltimore

    Registry updated 2026-10-28

  • NCT07322003

    Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

    Trial Treatment · Phase 3 · Prilenia

    Emory University, Atlanta · University of Colorado CU Anschutz Neurology, Aurora · Johns Hopkins University, Baltimore · Sean M. Healey & AMG Center for ALS, Boston · Northwestern University, Chicago · Texas Neurology, Dallas · University of Kansas, Fairway · Baylor College of Medicine; McNair Medical Campus, Houston · Mayo Clinic, Jacksonville · Somnos Clinical Research, Lincoln · Eleanor and Lou Gehrig ALS Center at Columbia University, New York · Neuroscience Department at LKSM at Temple University, Philadelphia · Barrow Neurological Institute, Phoenix · California Pacific Medical Center, San Francisco · University of Washington, Seattle · Swedish Medical Center, Seattle · Washington University, St Louis · University of South Florida, Tampa

    Registry updated 2026-10-27

  • NCT07855211

    A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)

    Trial Treatment · Phase 1/2 · Biogen

    Austin Neuromuscular Center_Austin, Austin · Washington University School of Medicine - St. Louis, St Louis

    Registry updated 2026-10-26

  • NCT07543367

    INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

    Trial Treatment · Synchron, Inc.

    University of Buffalo Neurosurgery, Buffalo · University of Texas Southwestern Medical Center (UTSW), Dallas · Mayo Clinic, Jacksonville · Mount Sinai Hospital, New York · University of Pittsburgh Medical Center (UPMC), Pittsburgh

    Registry updated 2026-10-21

  • NCT07871071

    Brain-Computer Interface Communication Device for People With ALS

    Trial Treatment · Cognixion

    Cognixion Corporation, Santa Barbara

    Registry updated 2026-10-16

  • NCT07454733

    Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?

    Trial Treatment · Trustees of Dartmouth College

    Massachusetts General Hospital, Boston · Penn State Health Milton S. Hersey Medical Center, Hershey · Mayo Clinic- Jacksonville, Jacksonville · Dartmouth-Hitchcock Health, Lebanon · University of Wisconsin Health, Madison · University of Pittsburgh Medical Center, Pittsburgh · Mayo Clinic Scottsdale, Scottsdale

    Registry updated 2026-10-08

  • NCT04363684

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

    Research · Mayo Clinic

    University of Michigan, Ann Arbor · Emory University, Atlanta · Johns Hopkins University, Baltimore · NIH, Bethesda · University of Alabama Birmingham, Birmingham · Massachusetts General Hospital, Boston · University of North Carolina, Chapel Hill, Chapel Hill · Northwestern University, Chicago · Case Western Reserve Medical Center, Cleveland · University of Colorado Denver, Denver · Nantz National Alzheimer Center Houston, Houston · Indiana University, Indianapolis · Mayo Clinic Florida, Jacksonville · University of California, Los Angeles, Los Angeles · Vanderbilt University, Nashville · Columbia University, New York · Mount Sinai, New York · University of Pennsylvania, Philadelphia · Mayo Clinic - Rochester, Rochester · UT San Antonio Health Science Center, San Antonio · University of California San Diego, San Diego · University of California San Francisco, San Francisco · University of Washington, Seattle · Washinton University in St. Louis, St Louis

    Registry updated 2026-10-07

  • NCT04220190

    RAPA-501 Therapy for ALS

    Trial Treatment · Phase 2/3 · Rapa Therapeutics LLC

    Massachusetts General Hospital, Boston

    Registry updated 2026-09-29

  • NCT07844590

    Developing New Ways to Detect Respiratory Impairment Early in ALS

    Research · Thomas Jefferson University

    Thomas Jefferson University - Center City, Philadelphia

    Registry updated 2026-09-28

  • NCT07838389

    Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS)

    Trial Treatment · Phase 1 · Mark Poznansky

    Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital, Boston

    Registry updated 2026-09-24

  • NCT06649955

    Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

    Trial Treatment · PathMaker Neurosystems Inc.

    Beth Israel Deaconess Medical Center, Boston

    Registry updated 2026-09-10

  • NCT07589764

    Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS

    Trial Treatment · Phase 1 · Duke University

    Duke University Medical Center, Durham · Temple University, Philadelphia

    Registry updated 2026-09-08

  • NCT07023835

    Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

    Trial Treatment · Phase 2 · Zydus Therapeutics Inc.

    Zydus US007, Atlanta · Zydus US010, Boston · Zydus US001, Dallas · Zydus US006, Detroit · Zydus US002, Houston · Zydus US015, La Jolla · Zydus US014, Lincoln · Zydus US005, New Britain · Zydus US008, Orange · Zydus US009, Pittsburgh · Zydus US004, Richmond · Zydus US013, San Francisco · Zydus US011, Seattle · Zydus US012, Tampa · Zydus US003, Winston-Salem

    Registry updated 2026-09-01

  • NCT07798700

    Biofluid Research on Age-Related or Inherited Neurodegeneration

    Research · University of Pennsylvania

    University of Pennsylvania, Philadelphia

    Registry updated 2026-09-01

  • NCT05474235

    Registry updated 2026-08-27

  • NCT06578195

    ASSESS ALL ALS Study

    Research · St. Joseph's Hospital and Medical Center, Phoenix

    University of Michigan, Ann Arbor · University of Colorado Anschutz Medical Campus, Aurora · John Hopkins University, Baltimore · Nih/Ninds, Bethseda · University of Alabama Birmingham, Birmingham · Saint Alphonsus Regional Medical Center, Boise · Massachusetts General Brigham, Boston · Synapticure (Remote Participation Only), Chicago · Northwestern University, Chicago · Ohio State University, Colombus · Texas Neurology, Dallas · Nova Southeastern University, Davie · Henry Ford Health, Detroit · Duke University, Durham · Penn State Health, Hershey · Indiana University, Indianapolis · University of California, Irvine, Irvine · Mayo Clinic, Jacksonville · University of California San Diego, La Jolla · Dartmouth Hitchcock Medical Center, Lebanon · University of California, Los Angeles, Los Angeles · University of Minnesota, Minneapolis · Vanderbilt University Medical Center, Nashville · Hospital for Special Care, New Britain · Columbia University, New York · University of Nebraska Medical Center, Omaha · Temple University, Philadelphia · University of Pennsylvania, Philadelphia · Barrow Neurological Institute, Phoenix · Providence ALS Center, Portland · Virginia Commonwealth University, Richmond · University of Utah, Salt Lake City · University of California San Francisco, San Francisco · University of Washington, Seattle · Washington University, St Louis · Georgetown University, Washington D.C.

    Registry updated 2026-08-24

  • NCT07295990

    Tongue-strengthening Exercises in People With ALS.

    Trial Treatment · Nova Southeastern University

    Nova Southeastern University, Davie

    Registry updated 2026-08-12

  • NCT07341334

    Digital Speech Markers for Monitoring ALS in Spanish Speakers

    Research · Nova Southeastern University

    Cathy J Husman ALS Center at Nova Southeastern University, Fort Lauderdale

    Registry updated 2026-08-03

  • NCT07743268

    Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS

    Trial Treatment · Phase 1/2 · n-Lorem Foundation

    Columbia University Irving Medical Center, New York · Washington University, St Louis

    Registry updated 2026-08-03

  • NCT06735014

    Multicenter ALS Imaging Study

    Research · University of Minnesota

    Northwestern University, Evanston · University of Florida, Gainesville · University of Minnesota, Minneapolis

    Registry updated 2026-07-31

  • NCT06704347

    Safety Study of XT-150 in Participants With ALS

    Trial Treatment · Phase 1 · Xalud Therapeutics, Inc.

    Johns Hopkins University, Baltimore · Massachusetts General Hospital, Boston · Henry Ford Health, Detroit · Barrow Neurological Institute (St. Joseph's), Phoenix

    Registry updated 2026-07-29

  • NCT07142291

    PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

    Trial Treatment · Phase 2 · PhenoNet, Inc.

    Mayo Clinic- Jacksonville, Jacksonville · University of California San Diego, La Jolla · Lange Neurology, New York · Sutter Health - California Pacific Medical Center Research Institute, San Francisco · Honor Health Neurology - Bob Bove Neuroscience Institute, Scottsdale

    Registry updated 2026-07-23

  • NCT07703462

    Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS

    Trial Treatment · Phase 1/2 · n-Lorem Foundation

    Jefferson Health, Philadelphia

    Registry updated 2026-07-14

All ALS (motor neurone disease) trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

ALS (motor neurone disease) trials in United States – Frontlight Research