ALS (motor neurone disease): open trials in United States

89 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT07224269
Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
Trial Treatment · Early phase 1 · University of Iowa
University of Iowa Health Care, Iowa City
Registry updated 2026-09-09
NCT07023835
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Trial Treatment · Phase 2 · Zydus Therapeutics Inc.
Zydus US007, Atlanta · Zydus US010, Boston · Zydus US001, Dallas · Zydus US006, Detroit · Zydus US002, Houston · Zydus US015, La Jolla · Zydus US014, Lincoln · Zydus US005, New Britain · Zydus US008, Orange · Zydus US009, Pittsburgh · Zydus US004, Richmond · Zydus US013, San Francisco · Zydus US011, Seattle · Zydus US012, Tampa · Zydus US003, Winston-Salem
Registry updated 2026-09-01
NCT07798700
Biofluid Research on Age-Related or Inherited Neurodegeneration
Research · University of Pennsylvania
University of Pennsylvania, Philadelphia
Registry updated 2026-09-01
NCT05474235
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
Research · Mayo Clinic
Mayo Clinic Florida, Jacksonville
Registry updated 2026-08-27
NCT03567213
Investigation on the Cortical Communication (CortiCom) System
Trial Treatment · Johns Hopkins University
Johns Hopkins Medicine, Baltimore
Registry updated 2026-08-21
NCT07295990
Tongue-strengthening Exercises in People With ALS.
Trial Treatment · Nova Southeastern University
Nova Southeastern University, Davie
Registry updated 2026-08-12
NCT06656702
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Trial Treatment · Early phase 1 · Johns Hopkins University
Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore
Registry updated 2026-08-11
NCT06266403
Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications
Trial Treatment · Penn State University
Speech Core, Pennsylvania State University, University Park
Registry updated 2026-08-07
NCT06609213
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
Trial Treatment · Andrea Charvet
Nova Southeastern University, Cathy J, Husman ALS Center, Fort Lauderdale
Registry updated 2026-08-04
NCT07341334
Digital Speech Markers for Monitoring ALS in Spanish Speakers
Research · Nova Southeastern University
Cathy J Husman ALS Center at Nova Southeastern University, Fort Lauderdale
Registry updated 2026-08-03
NCT07743268
Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS
Trial Treatment · Phase 1/2 · n-Lorem Foundation
Columbia University Irving Medical Center, New York · Washington University, St Louis
Registry updated 2026-08-03
NCT06735014
Multicenter ALS Imaging Study
Research · University of Minnesota
Northwestern University, Evanston · University of Florida, Gainesville · University of Minnesota, Minneapolis
Registry updated 2026-07-31
NCT06704347
Safety Study of XT-150 in Participants With ALS
Trial Treatment · Phase 1 · Xalud Therapeutics, Inc.
Johns Hopkins University, Baltimore · Massachusetts General Hospital, Boston · Henry Ford Health, Detroit · Barrow Neurological Institute (St. Joseph's), Phoenix
Registry updated 2026-07-29
NCT05470478
iBCI Optimization for Veterans With Paralysis
Trial Treatment · VA Office of Research and Development
Providence VA Medical Center, Providence, RI, Providence
Registry updated 2026-07-27
NCT07142291
PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS
Trial Treatment · Phase 2 · PhenoNet, Inc.
Mayo Clinic- Jacksonville, Jacksonville · University of California San Diego, La Jolla · Lange Neurology, New York · Sutter Health - California Pacific Medical Center Research Institute, San Francisco · Honor Health Neurology - Bob Bove Neuroscience Institute, Scottsdale
Registry updated 2026-07-23
NCT07703462
Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS
Trial Treatment · Phase 1/2 · n-Lorem Foundation
Jefferson Health, Philadelphia
Registry updated 2026-07-14
NCT07095686
Personalized Antisense Oligonucleotide for Participants With CHCHD10 ALS
Trial Treatment · Phase 1/2 · n-Lorem Foundation
Columbia University Irving Medical Center, New York
Registry updated 2026-07-13
NCT05067179
Analysis of Human ALS Tissues and Registry of ALS Patients
Research · University of Illinois Chicago
University of Illinois at Chicago, Chicago
Registry updated 2026-07-08
NCT07017946
Intestinal Microbiome Transplant in ALS
Trial Treatment · Phase 1/2 · Duke University
Duke University Medical Center, Durham
Registry updated 2026-07-08
NCT02795052
Neurologic Stem Cell Treatment Study
Trial Treatment · MD Stem Cells
MD Stem Cells, Coral Springs · MD Stem Cells, Westport
Registry updated 2026-06-26
NCT07071935
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Trial Treatment · Phase 2 · University of Pennsylvania
Penn State Hershey ALS Clinic, Hershey · Thomas Jefferson University Weinberg ALS Center, Philadelphi · Penn Comprehensive ALS Center at Pennsylvania Hospital, Philadelphia
Registry updated 2026-06-26
NCT07294144
Tofersen in Non-SOD1 ALS
Trial Treatment · Phase 2 · Washington University School of Medicine
Emory University, Atlanta · Massachusetts General Hospital, Boston · Washington University ALS Center, St Louis
Registry updated 2026-06-25
NCT07233148
Healing ALS Registry Observational Study (HAROS)
Research · Healing Advocates Registry and Ministry
Virtual, Park City
Registry updated 2026-06-24
NCT03489278
Clinical Procedures to Support Research in ALS
Research · University of Miami
Duke University, Durham · University of California, Irvine, Irvine · University of Kansas Medical Center, Kansas City · University of Miami, Miami · Hennepin County Medical Center, Minneapolis · Columbia University, New York · Stanford University, Palo Alto · Providence Health & Services, Portland · University of Texas - San Antonio - Health Science Center, San Antonio · California Pacific Medical Center, San Francisco · Wake Forest University, Winston-Salem
Registry updated 2026-06-15
NCT06527222
A Study of Ranolazine in ALS
Trial Treatment · Phase 2 · Swathy Chandrashekhar, MBBS
University of Missouri Health Care, Columbia · The Ohio State University, Columbus · University of Kansas Medical Center, Fairway · Mayo Clinic Florida, Jacksonville · University of California San Francisco, San Francisco · University of Kansas Medical Center: Wichita, Wichita
Registry updated 2026-06-08

All ALS (motor neurone disease) trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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