Brain metastases trials in United States

In United States 93 Also abroad 221

93 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
OBSERVE: A Pilot Study Of Omission Of Brain Metastasis Stereotactic Radiosurgery Following Resection With CNS-Active Systemic Therapy
Where
Houston
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07655583
Phase 2Taking people
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
Where
Chicago
Age
18 years and over
People
166
Run by
University of Chicago
See details and how to joinNCT02747303
No phaseTaking people
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
Where
Boston
Age
18 years and over
People
101
Run by
Brigham and Women's Hospital
See details and how to joinNCT04033497
Phase 2Taking people
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Where
Boston
Age
18 years and over
People
134
Run by
Brigham and Women's Hospital
See details and how to joinNCT04899908
Phase 1Taking people
A Phase 1/1b Study of IAM1363 in HER2 Cancers
Where
Ann Arbor, Aurora, Austin, Boston, Chicago, Cleveland, Dallas, Detroit, Durham, Fairfax, Grand Rapids, Houston, Kansas City, La Jolla, Lebanon, Los Angeles, Miami, Nashville, New Brunswick, New York, Oklahoma City, Portland, Seattle, St Louis, St. Petersburg, West Valley City
Age
18 years and over
People
383 worldwide
Run by
Iambic Therapeutics, Inc
See details and how to joinNCT06253871
No phaseTaking people
A Study of Stereotactic Radiosurgery (SRS) in People With Brain Cancer Having Tumor Resection Surgery
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
50
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07802353
Phase 2Taking people
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
Where
San Diego
Age
18 years and over
People
90
Run by
Jona Hattangadi-Gluth
See details and how to joinNCT04343157
No phaseTaking people
Targeted Pediatric High-Grade Glioma Therapy
Where
Ann Arbor, Aurora, Boston, Chicago, Cincinnati, Columbus, Durham, Houston, Miami, Philadelphia, Seattle, Washington D.C.
Age
12 months to 39 years
People
350 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT05839379
Phase 2Taking people
Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
Where
Boston
Age
18 years and over
People
150
Run by
Ayal A. Aizer, MD
See details and how to joinNCT07130786
Phase 2Taking people
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
Where
Boston
Age
18 years and over
People
60
Run by
Ayal A. Aizer, MD
See details and how to joinNCT07132190
Phase 1Taking people
A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors
Where
Austin, Chicago, Fairfax, Grand Rapids, Jacksonville, Lake Success, Nashville, New Haven, New Orleans, New York, Rochester, Scottsdale, St Louis, West Valley City
Age
18 years and over
People
100
Run by
Cogent Biosciences, Inc.
See details and how to joinNCT07361562
Phase 1Taking people
Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies
Where
Houston, New Haven, New York, Sacramento
Age
18 years and over
People
180 worldwide
Run by
Duke Street Bio Ltd
See details and how to joinNCT06458712 · EU 2023-508805-26-00
Phase 2Taking people
Study of Olutasidenib and Temozolomide in HGG
Where
Aurora, Boston, Chicago, Cincinnati, Columbus, Durham, Houston, Miami, Philadelphia, Seattle, Washington D.C.
Age
12 years to 39 years
People
60 worldwide
Run by
Rigel Pharmaceuticals
See details and how to joinNCT06161974
No phaseNot yet taking people in United States
Quality of Life for Patients With Breast Cancer Brain Metastases and Leptomeningeal Disease
Where
San Francisco
Age
18 years and over
People
200
Run by
University of California, San Francisco
See details and how to joinNCT07659652
Phase 2Taking people
A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases
Where
Augusta, Aurora, Baltimore, Chicago, Duarte, Houston, Kingwood, Las Vegas, Los Angeles, San Diego, Stony Brook, Webster
Age
18 years and over
People
120
Run by
Biostar Pharma, Inc.
See details and how to joinNCT06764940
Early phase 1Not yet taking people in United States
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors
Where
Birmingham
Age
18 months to 89 years
People
28
Run by
University of Alabama at Birmingham
See details and how to joinNCT05676489
Phase 1Taking people
A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases
Where
Charleston, Dallas, Detroit, Fairfax, Houston, Oklahoma City
Age
18 years and over
People
86
Run by
A2A Pharmaceuticals Inc.
See details and how to joinNCT06136884
Phase 1Taking people
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
Where
Dallas
Age
18 years and over
People
105
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07139990
No phaseTaking people
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Where
Chapel Hill
Age
18 years and over
People
20
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT04073966
Phase 2Taking people
Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection
Where
Houston
Age
18 years and over
People
28
Run by
The Methodist Hospital Research Institute
See details and how to joinNCT07383649
Phase 2Taking people
DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs
Where
Boston, Durham, Miami
Age
18 years and over
People
58
Run by
Nancy Lin, MD
See details and how to joinNCT06176261
No phaseTaking people
Phase I Study of Fractionated Stereotactic Radiation Therapy
Where
The Bronx
Age
18 years and over
People
43
Run by
Albert Einstein College of Medicine
See details and how to joinNCT03726359
No phaseTaking people
Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases
Where
Birmingham
Age
19 years and over
People
180
Run by
University of Alabama at Birmingham
See details and how to joinNCT06857006
Phase 2Taking people
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Where
Milwaukee
Age
18 years and over
People
53
Run by
Medical College of Wisconsin
See details and how to joinNCT05045950
Phase 2Not yet taking people in United States
Sac-TMT for Active TNBC Brain Metastases
Where
New Haven
Age
18 years and over
People
20
Run by
Yale University
See details and how to joinNCT07458113