Brain metastases trials in United States

In United States 93 Also abroad 221

93 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Where
Albany, Allentown, Atlanta, Boise, Boston, Carmel, Castro Valley, Chapel Hill, Chattanooga, Cincinnati, Clearwater, Dallas, Denver, Detroit, Englewood, Fairfax, Greenville, Hershey, Houston, Indianapolis, Jacksonville, Kansas City, Kettering, Laguna Hills, La Jolla, Little Rock, Louisville, Miami, Minneapolis, New York, Omaha, Orlando, Palm Springs, Phoenix, Pittsburgh, Providence, San Antonio, San Francisco, Seattle, Shreveport, Syracuse, Tampa, The Bronx, The Woodlands, Valhalla, Weston, Wilmington
People
600
Run by
GT Medical Technologies, Inc.
See details and how to joinNCT04427384
Phase 1/2Taking people
Asciminib in HER2+ Breast Cancer Brain Metastases
Where
Durham
Age
18 years and over
People
42
Run by
Duke University
See details and how to joinNCT07136428
Phase 2Taking people
Palbociclib and Pembrolizumab In Central Nervous System Metastases
Where
Boston
Age
18 years and over
People
45
Run by
Massachusetts General Hospital
See details and how to joinNCT02896335
Phase 2Taking people
Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer
Where
Buffalo, Charlottesville, Tampa
Age
18 years and over
People
23
Run by
Roswell Park Cancer Institute
See details and how to joinNCT04348747
Phase 2Taking people
Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance
Where
Winston-Salem
Age
18 years and over
People
60
Run by
Wake Forest University Health Sciences
See details and how to joinNCT05692635
Phase 2Taking people
A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05673928
Phase 2Taking people
Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05704647
Phase 1Taking people
Stereotactic Radiosurgery Dose Escalation for Brain Metastases
Where
Salt Lake City
Age
18 years and over
People
86
Run by
University of Utah
See details and how to joinNCT02390518
Phase 4Taking people
An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis
Where
Duarte
Age
18 years and over
People
10
Run by
City of Hope Medical Center
See details and how to joinNCT05376878
Phase 3Taking people
18F-FLUC PET/MR in Patients With Brain Mets
Where
Madison
Age
18 years and over
People
30
Run by
University of Wisconsin, Madison
See details and how to joinNCT06159335
Phase 2Taking people
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
62
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05419076
Phase 3Taking people
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Where
Annapolis, Ann Arbor, Asheville, Atlanta, Bethesda, Billings, Bismarck, Boca Raton, Boise, Boston, Cape Girardeau, Chicago, City of Saint Peters, Coral Gables, Corona, Creve Coeur, Danville, Decatur, Deerfield Beach, Des Moines, Duarte, Egg Harbor, Furlong, Great Falls, Greensboro, Greenville, Greenwood, Hollywood, Indianapolis, Irvine, Jacksonville, La Jolla, Lancaster, Lebanon, Maywood, Miami, Milwaukee, O'Fallon, Oklahoma City, Orange, Pembroke Pines, Peoria, Philadelphia, Plantation, Portland, Rancho Cordova, Rochester, Rohnert Park, Roseville, Sacramento, Saint Johnsbury, Saint Paul, Salt Lake City, Santa Clara, South Pasadena, South San Francisco, St Louis, Syracuse, Tampa, Torrance, Tucson, Upland, Urbana, Warrenville, Wilkes-Barre, Winston-Salem
Age
18 years and over
People
206 worldwide
Run by
Canadian Cancer Trials Group
See details and how to joinNCT03550391
Phase 2Taking people
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Where
Ann Arbor, Aurora, Boston, Chicago, Cincinnati, Columbus, Durham, Houston, Philadelphia, Seattle, Washington D.C.
Age
12 months to 39 years
People
120 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT05843253
No phaseTaking people
MeDex: No Perioperative Dexamethasone in Brain Metastases
Where
Louisville
Age
18 years and over
People
35
Run by
University of Louisville
See details and how to joinNCT07044557
Phase 2Taking people
Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial
Where
Burlington
Age
18 years and over
People
45
Run by
University of Vermont Medical Center
See details and how to joinNCT06974370
No phaseTaking people
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
Where
Philadelphia, Sewell
Age
18 years and over
People
90
Run by
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
See details and how to joinNCT03184038
Phase 1Taking people
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Where
Miami
Age
18 years and over
People
46
Run by
Baptist Health South Florida
See details and how to joinNCT06048094
Phase 2Taking people
Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases
Where
Palo Alto
Age
18 years and over
People
60
Run by
Stanford University
See details and how to joinNCT06712927
Phase 2Taking people
Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment
Where
Birmingham, Chicago, Cleveland, St Louis, Weston
Age
18 years and over
People
80 worldwide
Run by
Advenchen Pharmaceuticals, LLC.
See details and how to joinNCT05363280 · EU 2023-509067-24-01
Phase 2Taking people
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
Where
Detroit, Omaha
Age
18 years and over
People
100
Run by
University of Nebraska
See details and how to joinNCT04222062
Phase 1Taking people
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Where
Miami
Age
18 years and over
People
20
Run by
Baptist Health South Florida
See details and how to joinNCT04689048
Phase 2Taking people
Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1
Where
St Louis
Age
18 years and over
People
104
Run by
Washington University School of Medicine
See details and how to joinNCT07462507
Phase 1/2Taking people
A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
53
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07535463
Phase 2Taking people
NTS-WBRT in Brain Metastases
Where
Boston
Age
18 years and over
People
41
Run by
Massachusetts General Hospital
See details and how to joinNCT05013892
Phase 1/2Taking people
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
Where
Aurora, Columbus, Stanford
Age
18 years and over
People
56
Run by
Joshua Palmer
See details and how to joinNCT05987644