Brain metastases trials in United States

In United States 93 Also abroad 221

93 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases
Where
Charlottesville, Columbus, Richmond
Age
18 years and over
People
30
Run by
Ryan Gentzler, MD
See details and how to joinNCT06248606
Phase 1/2Taking people
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Where
New York
Age
19 years to 90 years
People
41
Run by
Weill Medical College of Cornell University
See details and how to joinNCT03449238
No phaseTaking people
Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment
Where
New York
Age
18 years and over
People
119
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05559853
Early phase 1Taking people
A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases
Where
Phoenix
Age
18 years and over
People
15
Run by
Nader Sanai
See details and how to joinNCT07268053
Phase 1Taking people
Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer
Where
Sacramento
Age
18 years and over
People
20
Run by
University of California, Davis
See details and how to joinNCT05452005
No phaseTaking people
Evaluation of the CONVIVO System
Where
Lebanon
Age
18 years and over
People
30
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT05139277
Phase 2Taking people
Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)
Where
Houston
Age
18 years and over
People
120
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05700721
No phaseTaking people
Multi-disciplinary Care for Brain Metastases
Where
Burlington
Age
18 years and over
People
40
Run by
University of Vermont Medical Center
See details and how to joinNCT06280300
No phaseTaking people
Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis
Where
Los Angeles
Age
18 years and over
People
42
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07339085
No phaseTaking people
Assessment of Eloquent Function in Brain Tumor Patients
Where
Omaha
Age
19 years and over
People
75
Run by
University of Nebraska
See details and how to joinNCT01535430
Phase 2Taking people
Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling
Where
Rochester
Age
18 years and over
People
22
Run by
University of Rochester
See details and how to joinNCT04965064
Phase 1/2Taking people
Sacituzumab Govitecan and Zimberelimab w/SRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases
Where
Tampa
Age
18 years and over
People
31
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT06238921
Phase 1/2Taking people
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma
Where
Iowa City, Salt Lake City
Age
18 years and over
People
33
Run by
University of Utah
See details and how to joinNCT06194929
No phaseTaking people
7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
Where
Columbia
Age
18 years and over
People
20
Run by
University of Missouri-Columbia
See details and how to joinNCT07175077
Phase 2Taking people
Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis
Where
Miami
Age
18 years and over
People
20
Run by
Baptist Health South Florida
See details and how to joinNCT05554302
No phaseTaking people
Stereotactic Magnetic Resonance Guided Radiation Therapy
Where
Boston
Age
18 years and over
People
397
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT04115254
Phase 1/2Taking people
A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.
Where
Boston, Denver, Fairfax, Houston, Lake Mary, San Antonio
Age
18 years to 89 years
People
130 worldwide
Run by
Eikon Therapeutics
See details and how to joinNCT06907043
Early phase 1Taking people
Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy
Where
Nashville
Age
18 years and over
People
48
Run by
Vanderbilt-Ingram Cancer Center
See details and how to joinNCT05996432