Liver cirrhosis trials in Italy

In Italy 25 Also abroad 358

25 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Where
Bologna, Catania, Foggia, Messina, Milan, Modena, Novara, Roma, Rozzano, San Giovanni Rotondo, Torino
Age
18 years to 80 years
People
2,150 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06528314
Phase 3Taking people
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Where
Bologna, Foggia, Milan, Modena, Palermo, Rome, Rozzano, San Giovanni Rotondo, Turin
Age
18 years and over
People
1,590 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632457 · EU 2024-513741-36-00
No phaseTaking people
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Where
Bari, Bergamo, Bologna, Milan, Pisa, Roma, Torino, Verona
Age
18 years and over
People
10,000 worldwide
Run by
University Medical Center Groningen
See details and how to joinNCT07585890
No phaseTaking people
VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)
Where
Florence
Age
18 years and over
People
152 worldwide
Run by
W.L.Gore & Associates
See details and how to joinNCT07390344
Phase 2Taking people
Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Where
Bologna, Florence, Milan, Padova, Palermo, Rome
Age
18 years to 75 years
People
360 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07631637 · EU 2026-525916-33-00
No phaseTaking people
Effectiveness and Clinical Outcomes of Long-term Bulevirtide Monotherapy in Patients With HDV-related Compensated Cirrhosis
Where
Milan
Age
18 years and over
People
266
Run by
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
See details and how to joinNCT06397859
No phaseNot yet taking people in Italy
Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement
Where
Rome
Age
18 years and over
People
150 worldwide
Run by
University Hospital Muenster
See details and how to joinNCT07877298
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Where
Bergamo, Foggia, Milan, Novara, Palermo, Rome, Rozzano, Turin
Age
18 years to 75 years
People
1,800 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06419374 · EU 2023-510395-31-00
Phase 2Not yet taking people in Italy
Prevention of venous thromboembolism in cirrhotic patients with hepatocellular carcinoma
Where
Padova, Rome
Age
18 years and over
People
70
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to join2026-526857-33-00
Phase 2Taking people
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
Where
Bologna, Turin
Age
18 years to 80 years
People
90 worldwide
Run by
European Foundation for Study of Chronic Liver Failure
See details and how to joinNCT05895136 · EU 2023-507073-18-00
No phaseTaking people
LEOPARD Training and Validation Data Collection Study
Where
Ancona, Bari, Bologna, Genova, Milan, Modena, Naples, Padova, Palermo, Pisa, Roma, Rome, Torino, Udine, Verona
Age
18 years to 70 years
People
4,500 worldwide
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06675604
No phaseTaking people
LEOPARD Prospective Validation Cohort 1
Where
Roma
Age
18 years to 70 years
People
630 worldwide
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06723275
Phase 3Taking people
Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients With Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome
Where
Palermo
Age
18 years to 80 years
People
72 worldwide
Run by
The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
See details and how to joinNCT06814626
Phase 2Taking people
Safety and efficacy of a human albumin solution with restored structural profile in patients with decompensated cirrhosis
Where
Bologna, Padova, Palermo, Salerno
Age
18 years and over
People
88
Run by
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
See details and how to join2024-515484-54-00
No phaseNot yet taking people in Italy
Multiparametric Ultrasound for the Noninvasive Diagnosis of Porto-sinusoidal Vascular Liver Disorder
Where
Roma
Age
18 years and over
People
100
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07492862
No phaseTaking people
Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide
Where
Roma
Age
18 years and over
People
20
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07429864
No phaseNot yet taking people in Italy
Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension
Where
Roma
Age
18 years and over
People
2,500
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07405749
No phaseTaking people
2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices
Where
Roma
Age
18 years and over
People
450
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07122622
No phaseTaking people
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Where
Bergamo, Bologna, Milan, Padova
Age
18 years to 80 years
People
3,000 worldwide
Run by
European Foundation for Study of Chronic Liver Failure
See details and how to joinNCT04613921
Phase 2Taking people
Dapagliflozin in the treatment of decompensated liver cirrhosis: phase IIb randomised, controlled clinical trial
Where
Bologna, Milan, Padova
Age
18 years and over
People
110
Run by
Azienda Ospedale-Universita Padova
See details and how to join2024-511964-95-00
No phaseNot yet taking people in Italy
Ketogenic Diet in MASLD-related cACLD
Where
Palermo
Age
18 years and over
People
50
Run by
University of Palermo
See details and how to joinNCT06537466
No phaseTaking people
The European NAFLD Registry
Where
Ancona, Milan, Palermo, Rome, Turin
Age
18 years to 100 years
People
10,000 worldwide
Run by
Newcastle University
See details and how to joinNCT04442334
No phaseTaking people
PROtocol of Metabolic and Cryptogenic livEr Disease regisTry for intEgration of Omic Studies
Where
Roma
Age
18 years and over
People
5,000
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT04371042
No phaseNot yet taking people in Italy
Hepatocarcinoma Recurrence on the Liver Study - Part2
Where
Bari, Bologna, Bolzano, Brescia, Forlì, Lecco, Mantua, Milan, Monza, Parma, Pavia, Rome, Rozzano, Savona, Treviso, Verona
Age
18 years and over
People
3,000
Run by
University of Milano Bicocca
See details and how to joinNCT04053231
No phaseTaking people
Cirrhosis, Effects of TRAnsplantation and Diabetes
Where
Milan
Age
18 years to 65 years
People
200
Run by
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
See details and how to joinNCT02038517