Colorectal cancer trials in France

In France 184 Also abroad 1943

184 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Besancon Cedex, Dijon, Lille, Limoges Cedex 1, Lorient, Marseille, Nantes, Paris, Pessac, Rouen, Saint-Herblain Cedex, Suresnes, Toulouse, Villejuif
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 1/2Taking people
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Where
Bordeau, Marseille, Paris, Poitiers, Villejuif
Age
18 years and over
People
542 worldwide
Run by
Artios Pharma Ltd
See details and how to joinNCT04657068
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
Besançon, Brest, Dijon, Marseille
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 1/2Taking people
First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer
Where
Bordeaux, Dijon, Lyon, Montpellier, Poitiers, Villejuif
Age
18 years to 75 years
People
90 worldwide
Run by
Brenus Pharma
See details and how to joinNCT06934538
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Dijon, Marseille, Paris, Poitiers, Rennes, Villejuif
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 3Taking people
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with FOLFOX versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer (HARMONi-GI3)
Where
Bordeaux, Creteil Cedex, Dijon, Lille, Lyon, Marseille, Montpellier Cedex 5, Nancy Cedex, Nantes, Nice Cedex 2, Paris, Paris Cedex 13, Pierre-Bénite, Poitiers, Reims, Strasbourg, Suresnes, Villejuif
Age
18 years and over
People
230 worldwide
Run by
Summit Therapeutics Inc.
See details and how to join2025-521587-35-00
No phaseNot yet taking people in France
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Where
Angers, Dijon, Limoges, Lyon, Nantes, Nîmes, Paris, Pessac, Rennes, Saint-Herblain, Vandœuvre-lès-Nancy
Age
18 years and over
People
1,200
Run by
University Hospital, Bordeaux
See details and how to joinNCT07871227
Phase 1Taking people
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Where
Lyon, Paris, Toulouse Cedex 9
Age
18 years and over
People
300 worldwide
Run by
Kura Oncology, Inc.
See details and how to joinNCT06026410 · EU 2024-513285-19-00
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
Dijon, Paris, Rennes, Villejuif
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00
Phase 1Taking people
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Where
Vandœuvre-lès-Nancy
Age
18 years and over
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07261631
No phaseTaking people
Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action
Where
Dijon
Age
18 years and over
People
306
Run by
Centre Hospitalier Universitaire Dijon
See details and how to joinNCT06600295
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Brest, Creteil Cedex, Dijon, Lille Cedex, Paris, Poitiers, Villejuif
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Bordeaux, Clermont-Ferrand, Lyon, Nîmes, Saint-Herblain, Strasbourg, Toulouse, Vandœuvre-lès-Nancy, Villejuif
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
No phaseTaking people
Butyrophilins Role in Colon Cancer
Where
Marseille
Age
18 years and over
People
200
Run by
Institut Paoli-Calmettes
See details and how to joinNCT04185272
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Besancon Cedex, Bordeaux, Caen Cedex 5, Clermont Ferrand Cedex1, Marseille, Nice Cedex 2, Paris, Rennes Cedex, Saint-Herblain, Strasbourg Cedex 2, Vandoeuvre Les Nancy_ Cedex, Villejuif
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 1Taking people
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Where
Bordeaux, Lyon, Montpellier, Saint-Cloud, Saint-Herblain, Villejuif
Age
18 years and over
People
392 worldwide
Run by
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
See details and how to joinNCT06625775 · EU 2024-519445-29-00
No phaseNot yet taking people in France
Optimizing Participation In Colorectal Cancer Screening By Direct Invitation Of Non Responders By General Practitionners
Where
Champlitte
Age
50 years to 74 years
People
10,000
Run by
MSPU des 3 Provinces
See details and how to joinNCT07639554
Phase 3Taking people
Personalizing chemotherapy selection after surgery for patients with stage III colorectal cancer using a blood test
Where
Amiens, Amiens Cedex 1, Angers, Annecy, Avignon Cedex 9, Bayeux, Beauvais, Besancon Cedex, Bordeaux, Boulogne-sur-Mer, Brest, Caen Cedex 5, Creil, Créteil, Dax, Dijon, Grenoble, Le Mans, Levallois-Perret, Lyon, Lyon Cedex 04, Marseille, Nantes Cedex 2, Paris, Pierre-Bénite, Poitiers, Reims Cedex, Rillieux-La-Pape, Rouen, Rouen Cedex, Saint-Grégoire, Saint-Herblain Cedex, Saint-Malo Cedex, Strasbourg, Suresnes, Trévenans, Vandoeuvre Les Nancy, Villejuif
Age
18 years and over
People
300 worldwide
Run by
Unicancer
See details and how to join2025-521045-24-00
No phaseTaking people
Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.
Where
Bayonne, Brest, Carhaix-Plouguer, Charenton-le-Pont, Limoges, Marseille, Nantes, Nîmes, Paris, Pessac, Rennes, Toulouse, Vandœuvre-lès-Nancy
Age
18 years and over
People
592
Run by
University Hospital, Bordeaux
See details and how to joinNCT07299071
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Bordeaux, Lyon, Suresnes
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 4Taking people
Evaluation of postoperative recovery when combining intravenous lidocaine with ropivacaine infiltration in laparoscopic colorectal oncologic surgery: a randomized controlled trial
Where
Amiens Cedex 1
Age
18 years and over
People
182
Run by
Centre Hospitalier Universitaire Amiens Picardie
See details and how to join2025-523207-29-00
Phase 1/2Taking people
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Where
Angers, Bordeaux, Bron, Lille, Lyon, Montpellier, Nantes, Strasbourg
Age
18 years and over
People
534 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06128551
Phase 1/2Taking people
A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer
Where
Lyon, Villejuif
Age
18 years and over
People
100 worldwide
Run by
SOTIO Biotech a.s.
See details and how to joinNCT07693751 · EU 2026-526235-19-00
Phase 3Taking people
EFFECTIVENESS OF EARLY INFORMATION AND ENDORSMENT BY GP TO INCREASE COLONOSCOPY FOLLOW-UP AND REDUCE DELAYS IN PEOPLE WITH A POSITIVE COLORECTAL CANCER SCREENING TEST. (SUIVICOLO)
Where
Tours
Age
50 years to 75 years
People
2,000
Run by
University Hospital, Caen
See details and how to joinNCT07520578
No phaseTaking people
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
Where
Besançon
Age
18 years and over
People
4,100 worldwide
Run by
Firalis SA
See details and how to joinNCT06515821