Colorectal cancer trials in Netherlands

In Netherlands 86 Also abroad 1929

86 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Where
Amsterdam
Age
18 years and over
People
534 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06128551
Phase 1/2Taking people
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
Where
Amsterdam, Utrecht
Age
18 years and over
People
47 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07213609
Phase 2Taking people
[68Ga]BED003 PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications
Where
Groningen, Nijmegen
Age
18 years to 79 years
People
71 worldwide
Run by
Blue Earth Diagnostics
See details and how to joinNCT07702292 · EU 2025-521983-36-00
Phase 1Taking people
A Phase 1/1b Study of IAM1363 in HER2 Cancers
Where
Amsterdam
Age
18 years and over
People
383 worldwide
Run by
Iambic Therapeutics, Inc
See details and how to joinNCT06253871
Phase 1Taking people
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Where
Groningen, Leiden
Age
12 years to 85 years
People
411 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT03715933 · EU 2023-508139-29-00
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Amsterdam, Dordrecht, Enschede, Groningen, Maastricht, Utrecht
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
No phaseTaking people
Irreversible Electroporation (IRE) for Treating Recurrent Pelvic Tumors (PELFIRE Study)
Where
Amsterdam
Age
18 years and over
People
27
Run by
Amsterdam UMC, location VUmc
See details and how to joinNCT07782164
Phase 1Taking people
Evaluating PD-1/PD-L1 in rectal cancer by quantitative fluorescence molecular endoscopy.
Where
Groningen
Age
18 years and over
People
23
Run by
Universitair Medisch Centrum Groningen
See details and how to joinNCT06304597 · EU 2023-507106-13-00
Phase 3Taking people
Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
Where
Amsterdam, Dordrecht, Enschede, Groningen, Maastricht, Utrecht
Age
18 years to 64 years
People
241 worldwide
Run by
Amgen Inc.
See details and how to join2022-502352-31-00
Phase 1Taking people
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
Where
Utrecht
Age
18 years and over
People
434 worldwide
Run by
Amgen
See details and how to joinNCT07094113
Phase 1Taking people
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Where
Nijmegen, Utrecht
Age
18 years to 100 years
People
162 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06562192
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Amsterdam, Utrecht, Venlo
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
Phase 1Taking people
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Where
Amsterdam, Groningen
Age
18 years and over
People
914 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT06131840 · EU 2023-505858-18-00
Phase 2Taking people
Randomized Study to Evaluate Melphalan/HDS Treatment Followed by Trifluridine–tipiracil plus Bevacizumab Versus Trifluridine–tipiracil plus Bevacizumab Alone in Metastatic Colorectal Cancer Patients
Where
Leiden
Age
18 years and over
People
35 worldwide
Run by
Delcath Systems Inc.
See details and how to join2024-520356-24-00
Phase 1/2Taking people
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Where
Amsterdam, Nijmegen, Rotterdam
Age
18 years and over
People
180 worldwide
Run by
Alentis Therapeutics AG
See details and how to joinNCT07169734 · EU 2025-521441-24-00
Phase 1Taking people
LB-100 (PP2A Inhibitor) and Atezolizumab (PD-L1 Inhibitor) in Metastatic Colorectal Cancer Patients
Where
Amsterdam
Age
18 years and over
People
37
Run by
The Netherlands Cancer Institute
See details and how to joinNCT06012734 · EU 2023-505534-98-00
Phase 2/3Taking people
Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE)
Where
Nieuwegein
Age
18 years and over
People
175 worldwide
Run by
GE Healthcare
See details and how to joinNCT07219238 · EU 2024-519384-18-00
No phaseTaking people
Prospective Data Collection Initiative on Colorectal Cancer
Where
Alkmaar, Almere Stad, Amersfoort, Amstelveen, Amsterdam, Apeldoorn, Arnhem, Assen, Beugen, Beverwijk, Breda, Capelle aan den IJssel, Delft, Deventer, Dirksland, Doetinchem, Dordrecht, Drachten, Ede, Eindhoven, Enschede, Geldrop, Goes, Gorinchem, Gouda, Groningen, Haarlem, Hardenberg, Harderwijk, Heerenveen, Helmond, Hengelo, Hilversum, Hoogeveen, Hoorn, Leeuwarden, Leiden, Maastricht, Nieuwegein, Nijmegen, Oss, Roermond, Roosendaal, Rotterdam, 's-Hertogenbosch, Sittard, Sneek, Terneuzen, The Hague, Tiel, Tilburg, Utrecht, Venlo, Weert, Winterswijk, Zaandam, Zwolle
Age
18 years and over
People
50,000
Run by
Dutch Colorectal Cancer Group
See details and how to joinNCT02070146
No phaseTaking people
Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients
Where
Rotterdam
Age
18 years and over
People
25
Run by
Claudia Schuurhuizen
See details and how to joinNCT07616297
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
Amsterdam, Groningen
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
No phaseTaking people
FAPI Molecular Imaging for Diagnosis of the CMS4 Unfavorable Colorectal Cancer Subtype
Where
Utrecht
Age
18 years and over
People
45
Run by
UMC Utrecht
See details and how to joinNCT06191120
Phase 1Taking people
Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-NNS309 in patients with pancreatic, lung, breast and colorectal cancers.
Where
Nijmegen, Utrecht
Age
18 years and over
People
76 worldwide
Run by
Novartis Pharma AG
See details and how to join2023-510356-23-00
No phaseTaking people
Circulating Tumor DNA Based Adjuvant Chemotherapy in Stage II Colon Cancer Patients: the MEDOCC-CrEATE Trial
Where
Alkmaar, Almelo, Almere Stad, Amersfoort, Amsterdam, Arnhem, Breda, Delft, Deventer, Dordrecht, Ede, Goes, Gorinchem, Haarlem, Harderwijk, Maastricht, Middelharnis, Nieuwegein, Nijmegen, Roosendaal, Rotterdam, 's-Hertogenbosch, The Hague, Uden, Utrecht, Veldhoven, Venlo, Weert
Age
18 years and over
People
1,320
Run by
UMC Utrecht
See details and how to joinNCT06434896
No phaseTaking people
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Where
Amsterdam, Deventer, Leeuwarden, Nijmegen, Utrecht
Age
18 years and over
People
8,000 worldwide
Run by
UMC Utrecht
See details and how to joinNCT04075305
Phase 1Taking people
The detection of tumor-associated fibrosis in colorectal peritoneal metastases by FAPI-PET (TROMPET)
Where
Amsterdam
Age
18 years and over
People
25
Run by
Universitair Medisch Centrum Utrecht
See details and how to join2024-512301-16-01