Crohn's disease trials in Italy

In Italy 52 Also abroad 422

52 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Where
Catanzaro, Messina, Milan, Monserrato, Negrar, Rome, Rozzano, San Giovanni Rotondo, Turin
Age
18 years to 75 years
People
590 worldwide
Run by
AbbVie
See details and how to joinNCT06548542 · EU 2024-513009-30-00
No phaseNot yet taking people in Italy
Development of the SC-IBD Self-Care Measurement Scale
Where
Roma
Age
18 years and over
People
275
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07494227
No phaseNot yet taking people in Italy
Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease
Where
Milan
Age
18 years and over
People
30
Run by
PhoenixLAB srls
See details and how to joinNCT07824726
Phase 1/2Taking people
Clostridium Butyricum in Stenosing Crohn's Disease
Where
Roma
Age
18 years to 85 years
People
40
Run by
San Giovanni Addolorata Hospital
See details and how to joinNCT07263880
No phaseTaking people
Comparison Between Artificial Intelligence and Standard Reading to Investigate Suspected Crohn Disease: the SCAI STUDY
Where
Brescia
Age
18 years to 75 years
People
180
Run by
Fondazione Poliambulanza Istituto Ospedaliero
See details and how to joinNCT07111715
Phase 3Taking people
Crohn’s Head-to-Head Assessing Risankizumab Versus Guselkumab for One Year
Where
Bologna, Bolzano, Catania, Genoa, Milan, Rome, Rozzano, Turin
Age
18 years and over
People
302 worldwide
Run by
Janssen Cilag International
See details and how to join2025-521590-13-00 · EU 2025-521590-13-00
Phase 3Taking people
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
Where
Messina, Milan, Pescara, Rome
Age
2 years to 17 years
People
70 worldwide
Run by
Takeda
See details and how to joinNCT06100289 · EU 2023-503188-40-00
No phaseNot yet taking people in Italy
TOLerogenic Potential of Hematopoietic Stem and Progenitor Cells and Inflammatory Bowel Disease
Where
Milan, Rome
Age
2 years to 18 years
People
80
Run by
IRCCS San Raffaele
See details and how to joinNCT07740499
No phaseTaking people
Prospective Risk Evaluation and Detection of Crohn's Disease in First-degree Relatives
Where
Roma
Age
16 years to 35 years
People
10,000 worldwide
Run by
GLSMED Learning Health S.A.
See details and how to joinNCT07316621
No phaseTaking people
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis
Where
Roma
Age
18 years to 80 years
People
20
Run by
Catholic University of the Sacred Heart
See details and how to joinNCT07724990
No phaseTaking people
Evaluation of the Accuracy of Immunostaining of Claudin 2 to Detect Active or Inactive Inflammation in Endoscopic Biopsies of IBD
Where
San Donato Milanese
Age
18 years and over
People
100
Run by
IRCCS Policlinico S. Donato
See details and how to joinNCT07710287
No phaseTaking people
Resting Energy Expenditure in Pediatric Patients With Inflammatory Bowel Disease (REE-MICI)
Where
Alessandria
Age
6 years to 17 years
People
50
Run by
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
See details and how to joinNCT07670975
No phaseTaking people
Partial Enteral Nutrition to Prevent Weight Loss and Sarcopenia in IBD Patients at Nutritional Risk - SIMBA
Where
Naples, Pavia, Roma, Rozzano
Age
18 years to 65 years
People
146
Run by
Lionhealth Srl Società Benefit
See details and how to joinNCT07433946
No phaseTaking people
A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting
Where
Bari, Bologna, Cagliari, Castellana Grotte, Catania, Catanzaro, Genova, Milan, Monserrato, Monza, Naples, Negrar, Palermo, Pescara, Roma, Rome, Rozzano, San Giovanni Rotondo, Turin
Age
18 years and over
People
250
Run by
AbbVie
See details and how to joinNCT07073079
Phase 3Taking people
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
Where
Cagliari, Milan, Naples, Padova, Rome, Rozzano, San Giovanni Rotondo, Turin
Age
18 years to 65 years
People
396 worldwide
Run by
Takeda
See details and how to joinNCT06227910 · EU 2023-509391-42-00
Phase 2Taking people
A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Where
Bologna, Milan, Palermo, Rome, Rozzano
Age
18 years to 75 years
People
192 worldwide
Run by
Takeda
See details and how to joinNCT06764615 · EU 2024-518914-18-00
No phaseTaking people
Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
Where
Florence, Naples, Rozzano
Age
18 years to 90 years
People
600 worldwide
Run by
Weill Medical College of Cornell University
See details and how to joinNCT03256240
Phase 3Taking people
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Where
Bologna, Florence, Monza, Naples, Rome
Age
2 years to 17 years
People
240 worldwide
Run by
Takeda
See details and how to joinNCT05442567 · EU 2023-509046-36-00
Phase 3Taking people
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
Where
Bologna, Florence, Naples, Rome
Age
2 years to 17 years
People
120 worldwide
Run by
Takeda
See details and how to joinNCT04779320 · EU 2023-509045-13-00
Phase 4Taking people
Prevention of Postoperative Endoscopic Recurrence With Endoscopy-driven Versus Systematic Biological Therapy
Where
Castellana Grotte, Florence, Milan
Age
18 years to 80 years
People
292 worldwide
Run by
Universitaire Ziekenhuizen KU Leuven
See details and how to joinNCT05169593
Phase 2Taking people
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
Where
Bologna, Catanzaro, Milan, Negrar, Pavia, Rome, Rozzano, San Giovanni Rotondo
Age
18 years to 75 years
People
212 worldwide
Run by
Abivax S.A.
See details and how to joinNCT06456593 · EU 2023-508234-34-00
No phaseTaking people
Impact of Exclusion Diet in Addition to Anti-TNF Therapy in Crohn's Disease and Ulcerative Colitis: a Prospective, Randomized, Double-arm, Open-label Study
Where
Milan
Age
18 years and over
People
80
Run by
IRCCS Ospedale San Raffaele
See details and how to joinNCT06896305
Phase 4Taking people
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
Where
Bologna, Milan, Rome, Rozzano, San Giovanni Rotondo
Age
18 years to 80 years
People
304 worldwide
Run by
Alimentiv Inc.
See details and how to joinNCT06257706 · EU 2023-509096-16-00
No phaseTaking people
Spatially and Temporally Resolving Predictive Biomarkers of Postoperative Recurrence and Complications in Chronic Intestinal Inflammation
Where
Milan
Age
18 years to 69 years
People
35
Run by
IRCCS Ospedale San Raffaele
See details and how to joinNCT06516341
No phaseTaking people
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
Where
Florence, Foggia, Palermo, Roma
People
90
Run by
Meyer Children's Hospital IRCCS
See details and how to joinNCT06862843