Depression trials in Germany

In Germany 39 Also abroad 667

32 of 39 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Not yet taking people in Germany
A Study to Assess the Change in Disease Activity and Adverse Events of AGN-151607-DP for the Treatment of Major Depressive Disorder in Adult Participants
Where
Bad Homburg, Erbach, Hamburg, Hanover
Age
18 years and over
People
40
Run by
AbbVie Deutschland GmbH & Co. KG
See details and how to join2025-525047-40-00 · EU 2025-525047-40-00
No phaseTaking people
Effects of rTMS Compared to SSRI as Early Treatment of Depression (Early-TMS)
Where
Tübingen
Age
18 years to 65 years
People
106
Run by
University Hospital Tuebingen
See details and how to joinNCT06545474
Phase 2Taking people
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Where
Bad Homburg, Berlin, Chemnitz, Schwerin
Age
18 years to 65 years
People
360 worldwide
Run by
Seaport Therapeutics
See details and how to joinNCT07065240 · EU 2025-521240-37-00
Phase 2Enrolling by invitation
An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)
Where
Bad Homburg, Berlin, Chemnitz, Schwerin
Age
18 years to 66 years
People
360 worldwide
Run by
Seaport Therapeutics
See details and how to joinNCT07161700 · EU 2025-522347-18-00
Phase 3Taking people
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Where
Aachen, Berlin, Bielefeld, Chemnitz, Mainz, Mannheim, Schwerin, Siegen
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07412756 · EU 2025-522308-25-00
Phase 3Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Where
Berlin, Chemnitz, Hamburg, Leipzig, Schwerin
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07775300 · EU 2025-522310-24-00
Phase 3Taking people
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Where
Berlin, Frankfurt Am Main, Homburg, Mannheim
Age
18 years to 85 years
People
330 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06793397 · EU 2024-519270-40-00
No phaseTaking people
IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
Where
Munich
Age
18 years to 65 years
People
42
Run by
Max-Planck-Institute of Psychiatry
See details and how to joinNCT07197138
Phase 3Taking people
Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression.
Where
Augsburg, Berlin, Frankfurt Am Main, Freiburg im Breisgau, Hamburg, Leipzig, Munich, Stralsund
Age
18 years to 75 years
People
320
Run by
Charite University, Berlin, Germany
See details and how to joinNCT07843927 · EU 2024-517963-21-00
Phase 3Enrolling by invitation
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
Where
Berlin, Frankfurt Am Main, Homburg, Mannheim
Age
18 years to 85 years
People
468 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06605105 · EU 2024-516805-22-00
Phase 2Taking people
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
Where
Berlin, Bonn, Frankfurt, Leipzig, München
Age
18 years to 65 years
People
105
Run by
Prof. Dr. Frank Behrens
See details and how to joinNCT06967857
Phase 3Taking people
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Where
Berlin, Chemnitz, Stralsund
Age
18 years to 65 years
People
500 worldwide
Run by
Vanda Pharmaceuticals
See details and how to joinNCT06830044 · EU 2024-520333-68-00
Phase 2Taking people
Randomized, placebo-controlled clinical trial to investigate the safety and efficacy of two dexamfetamine sulfate formulations in adults with ADHD and moderate to severe depression (DEXAD)
Where
Berlin, Bonn, Frankfurt Am Main, Leipzig, Munich
Age
18 years to 64 years
People
105
Run by
Fraunhofer Institute For Translational Medicine And Pharmacology ITMP
See details and how to join2024-515395-12-00 · EU 2024-515395-12-00
No phaseNot yet taking people in Germany
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
Where
Munich
Age
18 years and over
People
100
Run by
Technical University of Munich
See details and how to joinNCT07727005
No phaseTaking people
Accelerated Treatment of Depressive Patients With tDCS
Where
Regensburg
Age
18 years to 70 years
People
30
Run by
University of Regensburg
See details and how to joinNCT07444242
Phase 4Taking people
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Where
Bonn, Munich
Age
16 years to 70 years
People
2,500 worldwide
Run by
Parnassia Groep
See details and how to joinNCT05656469 · EU 2023-509680-25-00
No phaseTaking people
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Where
Berlin, Bonn, Hanover, Jena, Lübeck, Marburg, München, Tübingen
Age
18 years to 75 years
People
396
Run by
University of Greifswald
See details and how to joinNCT04996433
No phaseNot yet taking people in Germany
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
Where
Mannheim, München
Age
18 years to 65 years
People
140 worldwide
Run by
Ludwig-Maximilians - University of Munich
See details and how to joinNCT07586150
Phase 4Not yet taking people in Germany
Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression
Where
Frankfurt, Marburg
Age
18 years to 65 years
People
90
Run by
Goethe University
See details and how to joinNCT07488910
No phaseTaking people
Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation
Where
Steglitz
Age
18 years to 65 years
People
165
Run by
Charite University, Berlin, Germany
See details and how to joinNCT05909267
No phaseTaking people
Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches
Where
Marburg
Age
18 years to 80 years
People
150
Run by
Philipps University Marburg
See details and how to joinNCT07388004
No phaseEnrolling by invitation
The Effect of Digital Markers in the Self-management of Depressive Symptoms
Where
Frankfurt
Age
18 years and over
People
660 worldwide
Run by
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
See details and how to joinNCT06919133
No phaseTaking people
tVNS, Motivation, and Insulin Sensitivity
Where
Bonn
Age
18 years to 60 years
People
120
Run by
University of Bonn
See details and how to joinNCT07198100
Phase 1/2Taking people
Enoxolone in Major Depression - Biomarker-outcome Relationship
Where
Marburg
Age
18 years and over
People
80
Run by
Philipps University Marburg
See details and how to joinNCT05570110
Phase 3Taking people
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Where
Bielefeld, Dortmund, Frankfurt am Main, Mainz, Muenster
Age
18 years and over
People
418 worldwide
Run by
Dr. Inge Winter
See details and how to joinNCT05973786 · EU 2023-506605-19-00