Depression trials in United States

In United States 272 Also abroad 684

243 of 272 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Where
Bethesda, College Park
Age
8 years to 65 years
People
3,500
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT00018057
Phase 1Taking people
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Where
Bethesda
Age
18 years to 70 years
People
70
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT03973268
No phaseEnrolling by invitation
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Where
Houston
Age
22 years to 70 years
People
84
Run by
Baylor College of Medicine
See details and how to joinNCT05418894
No phaseNot yet taking people in United States
Sensory Synchronized Imaging and Neuromodulation
Where
Palo Alto
Age
18 years and over
People
250
Run by
VA Office of Research and Development
See details and how to joinNCT06548113
Phase 2Taking people
Precision Depression Adalimumab Trial
Where
Philadelphia
Age
18 years and over
People
60
Run by
Daniel Moriarity
See details and how to joinNCT07845604
Phase 4Taking people
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
Where
Boston
Age
18 years to 70 years
People
100
Run by
Massachusetts General Hospital
See details and how to joinNCT05450432
Phase 2Taking people
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Where
Allentown, Atlanta, Boston, Brooklyn, Cedarhurst, Chino, Cromwell, Dallas, Decatur, Everett, Garden Grove, Glendale, Independence, Irving, Jacksonville, Lauderhill, Marietta, New York, North Canton, Orlando, Palm Bay, Redlands, Richardson, Russells Mills, San Jose, Staten Island, St Louis, West Palm Beach
Age
18 years to 65 years
People
360 worldwide
Run by
Seaport Therapeutics
See details and how to joinNCT07065240 · EU 2025-521240-37-00
Phase 4Taking people
The Role of mGluR5 in CBT-I
Where
Stony Brook
Age
18 years and over
People
42
Run by
Stony Brook University
See details and how to joinNCT07076342
Phase 2Enrolling by invitation
An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)
Where
Atlanta, Boston, Brooklyn, Cedarhurst, Chino, Cromwell, Dallas, Decatur, Everett, Garden Grove, Glendale, Independence, Irving, Lauderhill, New York, North Canton, Palm Bay, Richardson, San Jose, Staten Island, St Louis, West Palm Beach
Age
18 years to 66 years
People
360 worldwide
Run by
Seaport Therapeutics
See details and how to joinNCT07161700 · EU 2025-522347-18-00
Phase 2Not yet taking people in United States
A Study of Brenipatide in Participants With Major Depressive Disorder
Where
Allentown, Atlanta, Austin, Bellevue, Boston, Cedarhurst, Chino, Dallas, Decatur, DeSoto, Fairfax, Hollywood, Jacksonville, Las Vegas, Marlton, Montclair, Mount Kisco, New York, Oceanside, Orlando, Philadelphia, Phoenix, Plant City, Savannah, Sherman Oaks, Staten Island, Tampa, Toms River, Watertown, West Hills, West Palm Beach
Age
18 years to 75 years
People
330 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07928245 · EU 2026-527689-65-00
Phase 1Taking people
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Where
Bethesda
Age
18 years to 65 years
People
150
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT03065335
Phase 3Taking people
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Where
Atlanta, Austin, Bennington, Boston, Chicago, Decatur, Denver, Draper, Jacksonville, Las Vegas, Little Rock, Maitland, New York, North Charleston, Orange, Orem, Orlando, Philadelphia, San Diego, Santa Monica, Savannah, Seattle, St Louis, Tampa, Worcester
Age
18 years to 74 years
People
165
Run by
Definium Therapeutics US, Inc.
See details and how to joinNCT07592689
No phaseTaking people
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Where
Atlanta, Houston, Iowa City
Age
22 years to 85 years
People
20
Run by
Motif Neurotech, Inc.
See details and how to joinNCT07594483
No phaseTaking people
Neuromodulation of Motivation and Reward Oscillations
Where
Tallahassee
Age
18 years to 55 years
People
54
Run by
Florida State University
See details and how to joinNCT07924852
No phaseTaking people
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
Where
Orlando
Age
60 years and over
People
84
Run by
AdventHealth
See details and how to joinNCT05877885
Phase 2Taking people
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
Where
New York
Age
21 years to 80 years
People
60
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06592833
Phase 4Taking people
Biomarker-Guided Antidepressant Selection
Where
New York
Age
18 years to 70 years
People
27
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07680140
Phase 2Taking people
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Where
Birmingham, Brooklyn, Cary, Chino, Denver, Flowood, Fort Myers, Glendale, Hollywood, Houston, Katy, La Jolla, Largo, Las Vegas, Lincoln, Marlton, North Canton, Orange, Orlando, Saint Charles, Salt Lake City, Tampa, The Woodlands, Watertown, West Hills, West Palm Beach, Worcester
Age
18 years to 65 years
People
153
Run by
ACADIA Pharmaceuticals Inc.
See details and how to joinNCT07284667
No phaseTaking people
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Where
Albuquerque, Amherst, Ammon, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Boca Raton, Boston, Brentwood, Brooksville, Buffalo, Burlingame, Cary, Charleston, Chicago, Cleveland, Colton, Columbia, Columbus, Costa Mesa, Dallas, Decatur, El Paso, Fairlawn, Flowood, Garfield Heights, Glen Burnie, Grayson, Hialeah, Houston, Huntington, Huntsville, Indianapolis, Jackson, Jacksonville, Joliet, Kansas City, La Jolla, Largo, Lauderhill, Lewiston, Lewisville, Lincoln, Los Angeles, Madison, Marietta, Mercer Island, Miami, Miami Springs, Minneapolis, Missouri City, Moosic, Morgantown, Naperville, Nashua, Neptune City, New York, O'Fallon, Oklahoma City, Orlando, Philadelphia, Pompano Beach, Raleigh, Roanoke, Royal Palm Beach, Saint Augustine, Salt Lake City, San Diego, San Rafael, Santa Ana, Seattle, Skokie, South Bend, Springfield, Staten Island, St Louis, Stony Brook, Syracuse, Tampa, Tulsa, West Palm Beach, Winfield, Winston-Salem, Woodbury, Woodstock
Age
18 years and over
People
6,800
Run by
LivaNova
See details and how to joinNCT03887715
Phase 2Taking people
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Where
New York
Age
18 years to 90 years
People
70
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06559826
No phaseTaking people
Peer-Delivered Behavioral Activation in a CCBHC
Where
Detroit
Age
18 years and over
People
250
Run by
Wayne State University
See details and how to joinNCT07219394
No phaseNot yet taking people in United States
Deaf CBT-TS to Reduce Suicide Risk
Where
Rochester
Age
18 years and over
People
110
Run by
University of Rochester
See details and how to joinNCT07279363
No phaseTaking people
IMST for Dementia Risk Reduction
Where
Tallahassee
Age
60 years to 80 years
People
30
Run by
Florida State University
See details and how to joinNCT07349706
Phase 3Taking people
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Where
Baltimore, Bellevue, Boston, Clinton, Decatur, DeSoto, Fairfax, Fort Worth, Foxborough, Hollywood, Indianapolis, Las Vegas, Maitland, Miami Gardens, Miami Lakes, Moorpark, Naples, New Haven, New York, Orange, Orange City, Orlando, Philadelphia, Portland, Shavano Park, Sioux Falls, St Louis, Tampa, Troy, Waterloo, Watertown, West Chester
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07412756 · EU 2025-522308-25-00
No phaseTaking people
Defining Neurobiological Links Between Substance Use and Mental Illness
Where
Baltimore
Age
18 years to 60 years
People
620
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT05538910