Depression trials in United States

In United States 272 Also abroad 666

28 of 272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Natural History of Depression, Bipolar Disorder and Suicide Risk
Where
Bethesda
Age
18 years to 120 years
People
500
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT06462196
No phaseTaking people
Tracking Response to Antidepressants in Advance of Investigational Trials
Where
Watertown
Age
18 years and over
People
400
Run by
Adams Clinical
See details and how to joinNCT04748276
No phaseTaking people
Characterization and Treatment of Adolescent Depression
Where
Bethesda, Denver, Los Angeles
Age
11 years to 25 years
People
4,100
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT03388606
No phaseTaking people
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Where
Bethesda
Age
8 years to 70 years
People
1,260
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT05669703
No phaseTaking people
Long-term Observation of Participants With Mood Disorders
Where
Bethesda
Age
18 years to 99 years
People
1,000
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT04877977
No phaseTaking people
Singula Phase 0.1 Primary Care Pilot
Where
Brentwood, Mount Kisco
Age
18 years and over
People
100
Run by
Singula Health, Inc.
See details and how to joinNCT07834684
No phaseNot yet taking people in United States
REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness
Where
Greenwich, New Haven
Age
22 years and over
People
50
Run by
Yale University
See details and how to joinNCT07792252
No phaseTaking people
The OBSERVE Protocol
Where
Ann Arbor, Atlanta, Bellaire, Milford, Moore, Nashville, New Haven, Seattle
People
450
Run by
Yale University
See details and how to joinNCT06725277
No phaseTaking people
Transition Care for FEP
Where
Chicago, Harvey
Age
18 years to 40 years
People
75
Run by
University of Chicago
See details and how to joinNCT07713849
No phaseTaking people
Triage Survey for Psychiatry Research Eligibility
Where
Boston, DeSoto, New York, Philadelphia, The Bronx, Watertown
Age
18 years and over
People
20,000
Run by
Adams Clinical
See details and how to joinNCT05800925
No phaseTaking people
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Where
Rochester
Age
18 years and over
People
200
Run by
Mayo Clinic
See details and how to joinNCT06897670
No phaseTaking people
ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
Where
Laguna Hills, La Jolla
Age
18 years and over
People
5,000
Run by
Salma Health, Inc.
See details and how to joinNCT07528014
No phaseTaking people
MicroRNA Correlates of Childhood Maltreatment and Suicidality
Where
Birmingham, Huntsville
Age
18 years to 60 years
People
450
Run by
University of Alabama at Birmingham
See details and how to joinNCT04923685
No phaseTaking people
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Where
St Louis
Age
21 years to 65 years
People
50
Run by
Washington University School of Medicine
See details and how to joinNCT05905705
No phaseTaking people
Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
Where
Athens, Belmont, Boston, Chicago, Dallas, Hartford
Age
18 years to 40 years
People
320
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT06740383
No phaseNot yet taking people in United States
Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Veterans and First Responders
Where
Waco
Age
18 years to 70 years
People
80
Run by
Baylor University
See details and how to joinNCT07452900
No phaseTaking people
University of Iowa Interventional Psychiatry Service Patient Registry
Where
Iowa City
Age
18 years to 99 years
People
1,000
Run by
Mark Niciu
See details and how to joinNCT04480918
No phaseTaking people
Impact of Depression on Thermoregulation
Where
University Park
Age
18 years to 40 years
People
64
Run by
Penn State University
See details and how to joinNCT06805851
No phaseEnrolling by invitation
Psychiatric Genotype/Phenotype Project Repository
Where
Nashville
Age
16 years to 65 years
People
2,000
Run by
Vanderbilt University
See details and how to joinNCT00762866
No phaseTaking people
The Effect of PROSE or Scleral Lenses on Mental Health
Where
Needham
People
200
Run by
Boston Sight
See details and how to joinNCT07195721
No phaseEnrolling by invitation
Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Where
Bellevue, Columbus, Costa Mesa, La Jolla, Los Angeles, Seattle, Sunnyvale
Age
18 years to 75 years
People
540
Run by
Kernel
See details and how to joinNCT06002100
No phaseTaking people
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Where
Pittsburgh, San Francisco
Age
65 years and over
People
120
Run by
University of Southern California
See details and how to joinNCT02434393
No phaseTaking people
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
Where
Belmont
Age
18 years to 45 years
People
228
Run by
Mclean Hospital
See details and how to joinNCT05630963
No phaseEnrolling by invitation
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
Where
Brookline, Zanesville
Age
13 years to 60 years
People
500
Run by
Psyrin Inc.
See details and how to joinNCT06792175
No phaseEnrolling by invitation
Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions
Where
New York, Sunnyvale
Age
18 years to 68 years
People
200
Run by
Psyrin Inc.
See details and how to joinNCT06823024