Head and neck cancer trials in United States

In United States 386 Also abroad 940

386 trials · From ClinicalTrials.gov, checked 10 Nov 2026. Ask the study team whether a trial fits you.

Phase 1/2RecruitingTrial-stage medicine
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer
Where
Bethesda
Age
18 years to 120 years
People
120
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07667400Registry updated 2026-11-09
Phase 2RecruitingTrial-stage medicine
Indocyanine Green With Near Infrared Imaging for Intraoperative Visualization of Head and Neck Squamous Cell Carcinoma
Where
St Louis
Age
18 years and over
People
25
Run by
Washington University School of Medicine
See details and how to joinNCT07825597Registry updated 2026-11-09
Phase 2Not yet recruitingTrial-stage medicine
Induction Chemoimmunotherapy to Prevent Laryngectomy in Advanced Laryngeal Cancer and Hypopharyngeal Cancer
Where
Rochester
Age
18 years and over
People
50
Run by
Mayo Clinic
See details and how to joinNCT07923877Registry updated 2026-11-09
No phaseNot yet recruitingResearch participation
Removing the Planning Tumor Volume From Radiation Therapy for the Treatment of Head and Neck Squamous Cell Carcinoma
Where
Duarte
Age
18 years and over
People
30
Run by
City of Hope Medical Center
See details and how to joinNCT07926906Registry updated 2026-11-09
Phase 1/2RecruitingTrial-stage medicine
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Where
Allentown, Atlanta, Billings, Camden, Chicago, Clermont, Cleveland, Dallas, Detroit, Duarte, El Paso, Fairfax, Glendale, Grand Island, Grand Rapids, Iowa City, Knoxville, La Jolla, Lakewood, Los Angeles, Louisville, Milwaukee, Murrieta, Nashville, Omaha, Orange City, Portland, Saint Louis Park, Saint Paul, San Antonio, Santa Rosa, St Louis, The Bronx, The Woodlands, Tyler
Age
18 years and over
People
340 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT04198766Registry updated 2026-11-06
No phaseRecruitingResearch participation
A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years to 89 years
People
185
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05207098Registry updated 2026-11-06
Phase 3RecruitingTrial-stage medicine
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
Where
Allentown, Ames, Anaconda, Ann Arbor, Aventura, Baltimore, Barrington, Basking Ridge, Bemidji, Bethlehem, Billings, Bismarck, Boise, Boone, Boston, Bozeman, Brighton, Burlington, Burnsville, Caldwell, Canton, Cape Girardeau, Carlisle, Cedar Rapids, Centerville, Chapel Hill, Charleston, Chelsea, Cherry Hill, Chicago, City of Saint Peters, Coeur d'Alene, Colorado Springs, Commack, Coon Rapids, Creve Coeur, Crown Point, Crystal Lake, Cudahy, Danville, Dayton, Decatur, Downers Grove, East Stroudsburg, Eau Claire, Edina, Effingham, Elgin, Erie, Fargo, Flint, Fort Collins, Fort Dodge, Franklin, Germantown, Glens Falls, Golden, Grafton, Great Falls, Greeley, Green Bay, Greensburg, Greenville, Harrisburg, Harrison, Hays, Hazel Crest, Hendersonville, Indiana, Jefferson, Johnstown, Kalispell, Kansas City, Kenosha, La Crosse, Lansing, Lawrence, Lawton, Lebanon, Lee's Summit, Liberty, Libertyville, Little Rock, Livonia, Loveland, Macomb, Maplewood, Marinette, Marshalltown, Marshfield, Marysville, Mattoon, Mechanicsburg, Miami Beach, Middletown, Milwaukee, Minneapolis, Missoula, Mitchell, Monroeville, Montvale, Mukwonago, Nampa, New Lenox, New York, Normal, Oak Lawn, Oconomowoc, O'Fallon, Oklahoma City, Olathe, Ontario, Oregon City, Orland Park, Osage Beach, Oshkosh, Overland Park, Palo Alto, Palos Heights, Park Ridge, Peoria, Philadelphia, Pierre, Pinehurst, Pittsburgh, Pontiac, Portland, Post Falls, Racine, Rice Lake, Richmond, Rockford, Saint Johnsbury, Saint Louis Park, Saint Paul, Salina, Sandpoint, Seneca, Sewell, Sheboygan, Shiloh, Sioux Falls, Springfield, Stevens Point, St Louis, Summit, Sylvania, Syracuse, Topeka, Troy, Two Rivers, Uniondale, Uniontown, Urbana, Verona, Washington, Waukesha, Wauwatosa, West Allis, Weston, Westwood, Yankton, Ypsilanti
Age
18 years and over
People
158
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06589804Registry updated 2026-11-06
Phase 2RecruitingResearch participation
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
Where
Baltimore, Columbia, Glen Burnie
Age
18 years and over
People
132
Run by
University of Maryland, Baltimore
See details and how to joinNCT07418034Registry updated 2026-11-06
Phase 2RecruitingTrial-stage medicine
Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial
Where
Rochester
Age
18 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT07783581Registry updated 2026-11-06
Phase 1RecruitingTrial-stage medicine
Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
Where
Chapel Hill
Age
18 years and over
People
33
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT06096038Registry updated 2026-11-05
Phase 1RecruitingTrial-stage medicine
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Where
Boston, Conroe, Duarte, Houston, Irvine, League City, Los Angeles, Nashville, New Haven, Newton, San Antonio, Santa Monica, Sugar Land, Trumbull
Age
18 years and over
People
540 worldwide
Run by
Pfizer
See details and how to joinNCT07090499EU 2025-521729-33-00Registry updated 2026-11-05
No phaseNot yet recruitingResearch participation
Gut-Liver-Muscle Axis in Cancer Cachexia
Where
Aurora
Age
40 years to 89 years
People
20
Run by
University of Colorado, Denver
See details and how to joinNCT07911150Registry updated 2026-11-05
Phase 1/2RecruitingTrial-stage medicine
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Where
Albuquerque, Englewood, Florham Park, Fort Lauderdale, Hartford, Houston, Morristown, New York, Pembroke Pines, Santa Rosa, Washington D.C., York
Age
18 years to 80 years
People
242 worldwide
Run by
VM Oncology, LLC
See details and how to joinNCT03556228Registry updated 2026-11-04
No phaseRecruitingResearch participation
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Where
Austin, Charleston, Cleveland, Corbin, Duarte, Elizabethtown, Florence, Gainesville, Lexington, Memphis, Miami, Minneapolis, Nashville, New Albany, Paducah, Portland, Rochester
Age
40 years and over
People
7,000
Run by
Adela, Inc
See details and how to joinNCT05366881Registry updated 2026-11-04
Phase 1RecruitingTrial-stage medicine
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Where
Athens, Birmingham, Boston, Buffalo, Fort Wayne, Margate, Nashville, Orlando, Palo Alto, Sarasota, Spokane
Age
18 years and over
People
85
Run by
Compass Therapeutics
See details and how to joinNCT06150664Registry updated 2026-11-04
Phase 1RecruitingTrial-stage medicine
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Where
Atlanta, Boston, Chicago, Cleveland, Denver, Duarte, Grand Rapids, Houston, Indianapolis, La Jolla, Los Angeles, Nashville, New York, Salt Lake City, San Antonio, St Louis, St. Petersburg, West Valley City
Age
18 years and over
People
460 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06465069EU 2024-512927-36-00Registry updated 2026-11-04
Early phase 1RecruitingResearch participation
PET/CT Assessment of Radiation-Induced Vascular Complications in Head and Neck Cancer
Where
Atlanta
Age
18 years and over
People
20
Run by
Emory University
See details and how to joinNCT06914999Registry updated 2026-11-04
Phase 3RecruitingTrial-stage medicine
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Where
Albert Lea, Ames, Anaconda, Antigo, Augusta, Aurora, Bakersfield, Barrington, Bath, Bellevue, Bemidji, Billings, Bismarck, Bloomington, Boise, Boone, Bozeman, Bridgeport, Brunswick, Buffalo, Burlington, Canton, Cape Girardeau, Carthage, Cedar Rapids, Cherry Hill, Cheyenne, Chicago, Clive, Coeur d'Alene, Colorado Springs, Columbus, Council Bluffs, Crystal Lake, Cudahy, Damariscotta, Danville, Decatur, Denver, Des Moines, Dickson City, Dixon, Downers Grove, Dublin, Eau Claire, Effingham, Elgin, Erie, Eureka, Fargo, Farmington, Farrell, Forest Hills, Fort Dodge, Fremont, Fresno, Fruitland, Galesburg, Germantown, Gilbert, Grafton, Great Falls, Green Bay, Greensburg, Greer, Harrisburg, Hazel Crest, Honolulu, Jefferson, Jefferson Hills, Joplin, Kalispell, Kearney, Kenosha, Kewanee, La Crosse, Lafayette, Lake Success, Lakewood, Lewisburg, Libertyville, Little Rock, Lone Tree, Los Angeles, Macomb, Mankato, Marinette, Marshalltown, Martinsburg, Mattoon, Mechanicsburg, Medford, Menomonee Falls, Meridian, Milwaukee, Missoula, Modesto, Moline, Monroeville, Morgantown, Mount Vernon, Nampa, Newport News, New York, Normal, Oak Creek, Oakland, Oak Lawn, O'Fallon, Oklahoma City, Omaha, Oshkosh, Ottawa, Palos Heights, Parkersburg, Park Ridge, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Portland, Post Falls, Pottsville, Princeton, Racine, Rego Park, Rhinelander, Rochester, Roseville, Sacramento, Saint Cloud, Salt Lake City, Sandpoint, Sanford, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, Scarborough, Scottsdale, Seneca, Sewell, Sheboygan, Sioux Falls, South Jordan, South Portland, South San Francisco, Spartanburg, Springfield, Stevens Point, St Louis, Stony Brook, Summit, Surprise, Tempe, The Bronx, Two Rivers, Urbana, Vallejo, Walnut Creek, Washington, Wausau, Wauwatosa, West Allis, West Bend, Wexford, Wheeling, Wilkes-Barre, Willow Grove, Wisconsin Rapids
Age
18 years and over
People
228
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT06992427Registry updated 2026-11-04
No phaseRecruitingResearch participation
Distance-Based Exercise to Preserve Function and Prevent Disability
Where
Boston, Butler, Cranberry Township, Dublin, Fremont, Fresno, Indiana, Kernersville, Mechanicsville, Midlothian, Modesto, Mount Airy, New Castle, Oakland, Pittsburgh, Richmond, Sacramento, San Francisco, San Jose, San Rafael, Santa Clara, Santa Rosa, Seneca, Vallejo, Walnut Creek, Winston-Salem
Age
18 years and over
People
104
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07059884Registry updated 2026-11-04
No phaseRecruitingResearch participation
Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer
Where
Boston
Age
18 years and over
People
10
Run by
Boston University Charles River Campus
See details and how to joinNCT07756684Registry updated 2026-11-04
No phaseRecruitingResearch participation
Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
Where
Aurora
Age
21 years to 90 years
People
700
Run by
University of Colorado, Denver
See details and how to joinNCT00900419Registry updated 2026-11-03
Phase 3RecruitingTrial-stage medicine
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Where
Atlanta, Birmingham, Boston, Chapel Hill, Charlotte, Charlottesville, Cincinnati, Duarte, Jacksonville, Laguna Hills, La Jolla, Lexington, Los Angeles, Newport Beach, New York, Norfolk, Oklahoma City, Orlando, Philadelphia, Portland, San Francisco, Santa Fe, Staten Island, Tampa, The Bronx, Washington D.C.
Age
60 years and over
People
500 worldwide
Run by
Johnson & Johnson Enterprise Innovation Inc.
See details and how to joinNCT04892173EU 2024-520386-31-00Registry updated 2026-11-03
Phase 2RecruitingTrial-stage medicine
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
Where
‘Aiea, Albuquerque, Alexandria, Ames, Anaconda, Ankeny, Ann Arbor, Ashland, Aurora, Battle Creek, Bellevue, Bemidji, Bend, Beverly Hills, Billings, Bismarck, Bloomington, Boise, Boone, Boston, Bozeman, Brainerd, Brighton, Burnsville, Caldwell, Canton, Cape Girardeau, Carthage, Cedar Rapids, Centerville, Centralia, Chaska, Chelsea, Chicago, City of Saint Peters, Clackamas, Clinton, Clive, Coeur d'Alene, Colorado Springs, Coon Rapids, Creve Coeur, Danville, Dayton, Decatur, Deer River, DeKalb, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, Eau Claire, Edina, Effingham, Escanaba, Eureka, Fairfax, Falls Church, Fargo, Farmington Hills, Flint, Fort Collins, Fort Dodge, Fosston, Franklin, Fridley, Fruitland, Galesburg, Geneva, Glenview, Goldsboro, Grand Rapids, Grayslake, Great Falls, Greeley, Green Bay, Greenville, Hibbing, Honolulu, Irvine, Jacksonville, Jamestown, Jefferson, Kalamazoo, Kalispell, Kewanee, La Crosse, Lake Forest, Lake Success, Lansing, Lebanon, Little Rock, Livonia, Los Angeles, Loveland, Lynchburg, Macomb, Maplewood, Marshalltown, Marshfield, Mattoon, Maywood, Meridian, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Mukwonago, Muskegon, Nampa, Newark, Newberg, New Richmond, New York, Niles, Normal, Norton Shores, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Omaha, Ontario, Orange, Oregon City, Orlando, Orland Park, Ottawa, Park Rapids, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pontiac, Portland, Post Falls, Princeton, Rapid City, Reed City, Rice Lake, Richmond, Rochester, Saint Johnsbury, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, Sandpoint, Sandstone, Sheboygan, Shiloh, Sioux Falls, Springfield, Stevens Point, St Louis, Stoneham, Sturgeon Bay, Superior, Tappahannock, Traverse City, Troy, Twin Falls, Urbana, Virginia, Waconia, Warrenville, Washington, Waukee, Waukesha, Weston, Willow Grove, Woodbury, Wyoming, Yorkville, Ypsilanti
Age
18 years and over
People
150
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05136196Registry updated 2026-11-03
Phase 1/2RecruitingTrial-stage medicine
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
Where
Ann Arbor, Aurora, Baltimore, Boston, Chapel Hill, Charlottesville, Chicago, Cleveland, Detroit, Fairfax, La Jolla, New Brunswick, New Haven, Salt Lake City, St Louis
Age
18 years and over
People
287 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06385080EU 2023-508418-40-00Registry updated 2026-11-03
Phase 1RecruitingTrial-stage medicine
A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma
Where
Atlanta, Birmingham, Boston, Chapel Hill, Duarte, Jacksonville, La Jolla, Philadelphia, Tampa, The Bronx
Age
18 years to 74 years
People
45 worldwide
Run by
Johnson & Johnson Enterprise Innovation Inc.
See details and how to joinNCT07219212EU 2025-522914-22-00Registry updated 2026-11-03

All Head and neck cancer trials and the map

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