Heart failure trials in Italy

In Italy 103 Also abroad 1265

103 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseNot yet taking people in Italy
Remote Monitoring and Optimization of Heart Failure Therapy
Where
Roma
Age
18 years to 85 years
People
800 worldwide
Run by
Zoll Medical Corporation
See details and how to joinNCT07622472
Phase 3Taking people
COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease
Where
Ancona, Bari, Bergamo, Busto Arsizio, Catania, Cesena, Foggia, Lecco, Milan, Palermo, Perugia, Reggio Emilia, Rimini, Rome, San Donato Milanese
Age
45 years and over
People
2,500 worldwide
Run by
Hamilton Health Sciences Corporation
See details and how to joinNCT05873881 · EU 2023-506675-96-00
No phaseTaking people
The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure
Where
Milan
Age
18 years and over
People
1,600
Run by
Fondazione Don Carlo Gnocchi ETS
See details and how to joinNCT07094737
Phase 3Taking people
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Ancona, Bergamo, Brescia, Milan, Pavia, Perugia, Riccione, Salerno, Sesto San Giovanni, Vizzolo Predabissi (MI)
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
No phaseTaking people
Left Bundle Branch Area Pacing (LBBAP) PMCF Study
Where
Cona
Age
18 years and over
People
200 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT07217392
Phase 4Taking people
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Where
Cagliari, Florence, Milan, Pavia, Perugia
Age
18 years to 130 years
People
60 worldwide
Run by
AstraZeneca
See details and how to joinNCT06651970
Phase 2Not yet taking people in Italy
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
Where
Ancona, Bologna, Brescia, Caserta, Ferrara, Milan, Naples, Pavia, Rome, Rozzano, Siena, Trieste
Age
18 years to 85 years
People
400 worldwide
Run by
AnaCardio AB
See details and how to joinNCT07584967 · EU 2025-524469-25-00
No phaseTaking people
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
Where
Campobasso
People
500 worldwide
Run by
CVRx, Inc.
See details and how to joinNCT02880618
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Where
Ancona, Bergamo, Brescia, Catanzaro, Genova, Varese
Age
18 years and over
People
5,200 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06008197
No phaseTaking people
RHYthm and Myocardial Function Relationship Evaluation in Heart Diseases
Where
Roma
Age
18 years and over
People
253
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07491237
No phaseNot yet taking people in Italy
KV-PREDICT Diagnostic Device in Patients With Heart Failure
Where
Modena
Age
18 years and over
People
120
Run by
KardioVis S.r.l.
See details and how to joinNCT07805213
No phaseNot yet taking people in Italy
BIOmarker Based Diagnostic TOOLkit to Personalise Pharmacological Approaches in Congestive Heart Failure: the BIOTOOL-CHF Validation Trial
Where
Bologna
Age
18 years and over
People
600
Run by
IRCCS Azienda Ospedaliero-Universitaria di Bologna
See details and how to joinNCT07635810
Phase 2Not yet taking people in Italy
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
Where
Bergamo, Brescia, Caserta, Florence, Milan, Rozzano
Age
18 years and over
People
369 worldwide
Run by
Cardurion Pharmaceuticals Inc.
See details and how to join2025-525033-31-00 · EU 2025-525033-31-00
No phaseTaking people
Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
Where
Bari, Milan, Pavia, Torino, Veruno
Age
18 years and over
People
419
Run by
Istituti Clinici Scientifici Maugeri SpA
See details and how to joinNCT07741305
Phase 3Taking people
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Where
Bentivoglio, Bergamo, Bologna, Brescia, Chieti, Cosenza, Cremona, Ferrara, Genoa, Grosseto, Latina, Messina, Milan, Naples, Padova, Palermo, Pavia, Perugia, Pisa, Reggio Emilia, Rome, Rozzano, San Donato Milanese, Sassari, Siena, Treviso, Udine, Varese
Age
18 years and over
People
5,610 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07567001 · EU 2025-523717-29-00
No phaseTaking people
Alleviant ALLAY-HF Study
Where
Milan, Rozzano
Age
40 years and over
People
700 worldwide
Run by
Alleviant Medical, Inc.
See details and how to joinNCT05685303
No phaseTaking people
Liver and Coagulation Disorders in Cardiac Transthyretin Amyloidosis
Where
Messina
Age
18 years and over
People
70
Run by
University of Messina
See details and how to joinNCT07766135
Phase 4Taking people
Pharmacological optimization in prevention in Heart Failure: A Sex-gap?
Where
Ancona, Bari, Cecina, Ferrara, Florence, Milan, Pisa, Ravenna, Reggio Emilia, Rome, San Donato Milanese
Age
18 years and over
People
368
Run by
Policlinico San Donato S.p.A.
See details and how to join2025-520660-18-00 · EU 2025-520660-18-00
No phaseTaking people
Early Detection and IntervenTion in Heart Failure
Where
Pisa
Age
65 years and over
People
18,000 worldwide
Run by
University Hospital, Basel, Switzerland
See details and how to joinNCT07731490
Phase 3Taking people
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
Where
Brescia, Germaneto
Age
18 years and over
People
2,600 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06033950
No phaseTaking people
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.
Where
Bergamo
Age
18 years and over
People
300
Run by
FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
See details and how to joinNCT06626685
No phaseTaking people
Acute Response to Left Bundle Branch Area Pacing With SyncAV
Where
San Donato Milanese
Age
18 years and over
People
50
Run by
Abbott Medical Devices
See details and how to joinNCT06436053
No phaseTaking people
Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure
Where
Bergamo, Milan
Age
18 years to 75 years
People
300
Run by
Università Vita-Salute San Raffaele
See details and how to joinNCT07560982
No phaseTaking people
Transcultural Digital Solutions in Phase III Cardiac Rehabilitation
Where
Castellanza, Lumezzane, Milan
Age
18 years and over
People
306 worldwide
Run by
Fondazione Don Carlo Gnocchi ETS
See details and how to joinNCT07252856
No phaseTaking people
The AFteR Registry - Follow-up Study to Monitor the Efficacy and Safety of the Occlutech AFR in Heart Failure Patients
Where
Florence, Milan
Age
18 years and over
People
150 worldwide
Run by
Occlutech International AB
See details and how to joinNCT04405583