HIV: open trials in South Africa

55 open trials have a site in South Africa. Registry data; only the trial team decides who can take part.

NCT07266831
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Josha Research ( Site 4302), Bloemfontein · Wentworth Hospital ( Site 4303), Durban · Be Part Yoluntu Centre ( Site 4300), Mbekweni, Paarl
Registry updated 2026-11-04
NCT07645378
Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa
Trial Treatment · Fred Hutchinson Cancer Center
Centre for the AIDS Programme of Research in South Africa, Durban
Registry updated 2026-11-03
NCT05947890
Evaluating the Safety and Immunogenicity of MTBVAC
Trial Treatment · Phase 2 · HIV Vaccine Trials Network
Cape Town - Groote Schuur, Cape Town · Cape Town - Khayelitsha, Cape Town · Cape Town - UCTLI, Cape Town · Cape Town - Emavundleni, Cape Town · Durban - Chatsworth, Chatsworth · Durban - Wentworth, Durban · Durban - Botha's Hill CRS, Durban · Durban eThekwini, Durban · Durban - Isipingo, Isipingo · Soweto - Gauteng, Johannesburg · Klerksdorp, Klerksdorp · Ladysmith, Ladysmith · Rustenburg CRS, Rustenburg · Soshanguve, Soshanguve · Johannesburg - CHRU, Westdene · Worcester - SATVI, Worcester
Registry updated 2026-10-30
NCT04375800
Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
FARMOVS PTY LTD ( Site 0601), Bloemfontein · Family Clinic Research With UBUNTU ( Site 0605), Cape Town · King Edward Hospital ( Site 0600), Durban · Perinatal HIV Research Unit ( Site 0602), Johannesburg · Wits Reproductive Health and HIV Institute (WRHI) ( Site 0603), Johannesburg · Empilweni Services and Research Unit ( Site 0604), Johannesburg · Be Part Yoluntu Centre ( Site 0606), Paarl · Tsitsikamma Clinical Research Initiative (TCRI) ( Site 0607), Plettenberg Bay
Registry updated 2026-10-27
NCT06483854
Healer-initiated HIV Counseling and Testing Versus Standard of Care in Rural South Africa
Trial Treatment · Vanderbilt University Medical Center
Bushbuckridge, Agincourt
Registry updated 2026-10-23
NCT07071623
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Josha Research ( Site 0045), Bloemfontein · Desmond Tutu Health Foundation. Philippi Village ( Site 0024), Cape Town · DTHF Masiphumelele Clinical Research Site ( Site 0023), Cape Town · SA Medical Research Council - Chatsworth Clinical Research Site ( Site 0026), Chatsworth · SA Medical Research Council - Botha's Hill Clinical Research Site ( Site 0035), Durban · Wits Maternal Adolescent and Child Health Research Unit (WMRU) ( Site 0027), Durban · Umlazi Clinical Research Site ( Site 0047), Durban · CAPRISA eThekwini Clinical Research Site ( Site 0030), Durban · Synergy Biomed Research Institute ( Site 0040), East London · SYNAPSE Research Clinic ( Site 0043), Edendale · Wits RHI Ward 21 Clinical Research site ( Site 0022), Johannesburg · Helen Joseph Hospital-Clinical HIV Research Unit ( Site 0048), Johannesburg · Perinatal HIV Research Unit (PHRU) ( Site 0033), Johnnesburg · Vuka Research Clinic ( Site 0025), Khayelitsha · Qhakaza Mbokodo Research Clinic ( Site 0028), Ladysmith · Foundation For Professional Development ( Site 0031), Ndevana · SA Medical Research Council - Phoenix Clinical Research Site ( Site 0037), Phoenix · CAPRISA Vulindlela Clinical Research Site ( Site 0029), Pietermaritzburg · Setshaba Research Centre ( Site 0032), Pretoria · Africa Health Research Institute (AHRI) - Mtubatuba ( Site 0049), Somkhele - Mtubatuba · SA Medical Research Council - Verulam Clinical Research Site ( Site 0036), Verulam
Registry updated 2026-10-20
NCT05413122
Evaluating Smoking Cessation Interventions for PWH in South Africa
Trial Treatment · Phase 2/3 · Johns Hopkins University
Perinatal HIV Research Unit (PHRU), Soweto
Registry updated 2026-10-19
NCT06337032
A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
Trial Treatment · Phase 4 · Gilead Sciences
University of Stellenbosch, Cape Town · Enhancing Care Foundation, Durban · WITS RHI Research Centre, Johannesburg · Rahima Moosa Mother and Child Hospital, Johannesburg · Be Part Yoluntu Centre, Paarl · The Aurun Institute, Pretoria · Perinatal HIV Research Unit, Soweto
Registry updated 2026-10-19
NCT07698600
A Clinical Trial to Look at the Safety and Immune Responses of the RNA-based Vaccine BNT168 in Adults Living With or Without HIV
Trial Treatment · Phase 1 · BioNTech SE
Clinical HIV Research Unit (CHRU), Johannesburg · Wits RHI - Shandukani Research, Johannesburg · Perinatal HIV Research Unit (PHRU), Johannesburg
Registry updated 2026-10-14
NCT07563309
A Study to Evaluate Performance, Usability, and Contrived Result Interpretation of TruPlex HIV/HepB/Syphilis Rapid Test
Trial Treatment · bioLytical Laboratories
Epicentre Health Research (Cape Town), Cape Town · Epicentre Health Research, Durban · Epicentre Health Research (Johannesburg), Johannesburg
Registry updated 2026-10-02
NCT05413798
Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa
Trial Treatment · UNC Lineberger Comprehensive Cancer Center
Clinical HIV Research Unit Temba Lethu Wing Helen Joseph Hospital, Westdene
Registry updated 2026-09-30
NCT07032363
Implementing Depression and Adherence Treatment
Trial Treatment · University of Miami
University of Cape Town, Cape Town
Registry updated 2026-09-21
NCT06613789
Safety & Immunogenicity of 426c.Mod.Core-C4b Vaccine With 3M-052-AF+Alum in Infants Perinatally Exposed to HIV But Uninfected
Trial Treatment · Phase 1 · HIV Vaccine Trials Network
Soweto HVTN CRS, Soweto
Registry updated 2026-09-18
NCT02140255
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
Trial Treatment · Phase 1/2 · National Institute of Allergy and Infectious Diseases (NIAID)
Durban · Soweto IMPAACT CRS, Johannesburg · Wits RHI Shandukani Research Centre CRS, Johannesburg · Tygerberg
Registry updated 2026-09-09
NCT05842161
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Trial Treatment · Massachusetts General Hospital
University of Cape Town, Rondebosch
Registry updated 2026-09-09
NCT06152003
Intervention Development for Syndemics Among PWH in SA
Trial Treatment · Massachusetts General Hospital
University of Cape Town, Cape Town
Registry updated 2026-09-09
NCT07703891
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Trial Treatment · University of Pennsylvania
Health Economics and Epidemiology Research Office (HE2RO), University of the Witwatersrand, Johannesburg
Registry updated 2026-08-27
NCT07393659
A Continued Access Study for Participants Transitioning From ViiV Healthcare-sponsored or ViiV Healthcare-collaborative Parent Studies for HIV Treatment
Trial Treatment · Phase 3 · ViiV Healthcare
Durban · Gauteng · Johannesburg · Jouberton
Registry updated 2026-08-14
NCT07741474
Community Popular Opinion Leader Intervention for HIV Prevention Uptake in Rural South Africa
Trial Treatment · Africa Health Research Institute
Africa Health Research Institute, uMkhanyakude
Registry updated 2026-08-03
NCT07102745
HomeLink2: Reducing Posthospitalization Mortality Through Structured Home Care and Nutritional Support
Trial Treatment · Johns Hopkins University
Tshepong Hospital, Klerksdorp
Registry updated 2026-07-22
NCT05624931
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Trial Treatment · Boston University Charles River Campus
Gugulethu Midwife Obstetric Unit (MOU), Cape Town
Registry updated 2026-07-17
NCT06250504
Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT
Trial Treatment · Phase 3 · Africa Health Research Institute
Africa Health Research Institute, Somkele
Registry updated 2026-07-09
NCT06962592
Mentor Moms+ Study
Trial Treatment · University of California, Los Angeles
Saldanha Bay Municipality Clinic, Cape Town · Saldanha Bay Clinics, Saldanha Bay
Registry updated 2026-07-02
NCT07675629
Evaluating the Safety and Immunogenicity of Polyvalent DNA and Recombinant gp120 Protein HIV Vaccine (PDPHV) in Healthy, HIV-uninfected Adults
Trial Treatment · Phase 2 · Worcester HIV Vaccine
Emavundleni Clinical Research Site, Desmond Tutu Health Foundation, Cape Town
Registry updated 2026-06-30
NCT07666139
The 'Comprehensive Adherence Resource and Empowerment Support' (CARES) Study
Trial Treatment · RTI International
Desmond Tutu Health Foundation, Cape Town
Registry updated 2026-06-26

All HIV trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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