HIV: open trials in South Africa

56 open trials have a site in South Africa. Registry data; only the trial team decides who can take part.

NCT07666139
The 'Comprehensive Adherence Resource and Empowerment Support' (CARES) Study
Trial Treatment · RTI International
Desmond Tutu Health Foundation, Cape Town
Registry updated 2026-06-26
NCT06485154
Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial
Trial Treatment · Phase 4 · University of Witwatersrand, South Africa
Desmond Tutu Health Foundation, Cape Town · Africa Health Research Institute (AHRI), Durban · Ezintsha, a division of Wits Health Consortium, Johannesburg
Registry updated 2026-06-09
NCT06027671
Structured Peer-delivered ART and Reentry Community Strategy
Trial Treatment · Johns Hopkins University
The Aurum Institute - Head office, Johannesburg
Registry updated 2026-06-02
NCT07226323
Testing the WeCare Intervention to Address Mental Health and Medication Adherence Challenges Among MSM in South Africa
Trial Treatment · Emory University
Aurum Institute, Johannesburg
Registry updated 2026-05-29
NCT05633056
An Adaptive Randomized Controlled Trial
Trial Treatment · Columbia University
King DinuZulu Hospital, Durban
Registry updated 2026-05-28
NCT07275606
A Study to Investigate Cabotegravir for Neonates Exposed to HIV-1
Trial Treatment · Phase 1/2 · ViiV Healthcare
Parow Valley
Registry updated 2026-05-19
NCT07564193
The Coach Mpilo Study: Evaluation of a Peer-led Intervention to Promote Engagement in HIV Care for Men Living With HIV
Trial Treatment · University of Cape Town
Multisite study with several health care facilities, Durban
Registry updated 2026-05-11
NCT04700579
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
Research · University of Stellenbosch
Scottsdene Clinic, Cape Town · Wallacedene Clinic, Cape Town · Kraaifontein Community Health Centre, Cape Town
Registry updated 2026-05-06
NCT06857071
Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
Trial Treatment · University of Illinois Chicago
Centre for Community-based Research, Human Sciences Research Council, Pietermaritzburg
Registry updated 2026-04-13
NCT06721078
Evaluation of Long-Acting Injectable (LAI) and Teen Clubs in Adolescents (ATTUNE).
Trial Treatment · Africa Health Research Institute
Michael Mapongwana CHC, Cape Town · Eerste River Hospital, Cape Town · KwaMashu CHC, Durban · Cato Manor CHC, Durban · Rahima Moosa Mother and Child Hospital, Johannesburg · Charlotte Maxeke Hospital, Johannesburg · Somkhele CHC, Mtubatuba · Mtubatuba CHC, Mtubatuba · Kgabo CHC, Pretoria · Soshanguve Block TT, Pretoria · KT Motubatse CHC, Pretoria · Soshanguve Block JJ, Pretoria
Registry updated 2026-04-03
NCT07439003
Behavioral Risk Identification and Decision Guidance for HIV Engagement
Research · Boston University
Health Economics and Epidemiology Research Office, Johannesburg
Registry updated 2026-04-02
NCT07428577
Tracking and Continuity of Care in Advanced HIV Disease
Research · Boston University
Helen Joseph Hospital, Johannesburg
Registry updated 2026-03-31
NCT07194902
HIV Self-testing for Partners of HIV-uninfected Postpartum Women
Trial Treatment · Massachusetts General Hospital
Wits MatCH Research Unit, Durban
Registry updated 2026-03-23
NCT05373758
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa
Trial Treatment · Massachusetts General Hospital
RK Khan Hospital Clinic, Durban
Registry updated 2026-03-19
NCT07439562
Choice-Based Support for Adults Starting or Restarting Antiretroviral Therapy in Cape Town, South Africa
Trial Treatment · University of Cape Town
Gugulethu Community Health Centre, Cape Town
Registry updated 2026-02-27
NCT05630638
Doravirine Dose Optimisation in Pregnancy
Trial Treatment · Phase 4 · University of Liverpool
Desmond Tutu Health Foundation, Cape Town
Registry updated 2026-02-19
NCT06617091
A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.
Trial Treatment · Phase 1 · International AIDS Vaccine Initiative
DTHF, Cape Town · AHRI, Mtubatuba
Registry updated 2026-02-13
NCT07390409
ALIGN: A Non-randomised Study Delivering Injectable Lenacapavir for HIV Prevention Within a Pre-exposure Prophylaxis (PrEP) Choice Context in Cape Town, South Africa.
Research · Desmond Tutu HIV Foundation
DTHF Mobile Clinics, Cape Town
Registry updated 2026-02-05
NCT06408142
Universal Test and Connect for HIV Service Delivery in South Africa
Research · Johns Hopkins University
Gugulethu Community Health Centre, Cape Town
Registry updated 2026-01-30
NCT05553236
Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis
Trial Treatment · University of California, San Francisco
South African National Health Laboratory Service, Cape Town
Registry updated 2026-01-26
NCT06554223
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
Trial Treatment · Brigham and Women's Hospital
University of Cape Town, Cape Town
Registry updated 2025-11-24
NCT04149782
Gathering Records to Evaluate Antiretroviral Treatment-South Africa
Research · Boston University
All clinics, Johannesburg
Registry updated 2025-11-17
NCT05580666
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Trial Treatment · Phase 3 · Population Health Research Institute
Ubuntu Clinic, Site B, Khayelitsha, Wellcome Centre, Cape Town · Groote Schuur Hospital -New main building, Infectious Disease Clinic G26, Cape Town · Desmond Tutu Health Foundation, Cape Town · New Somerset Hospital, Cape Town · Africa Health Research Institute (AHRI)- Nkundusi Clinic, Hlabisa · Africa Health Research Institute (AHRI)- Hluhluwe Clinic, Hluhluwe · Wits Health Consortium (Pty) Ltd, Johannesburg · The Aurum Institute, Klerksdorp · Africa Health Research Institute (AHRI)- KwaMsane Clinic, Mtubatuba · Africa Health Research Institute (AHRI)- Somkhele Clinic, Mtubatuba · Africa Health Research Institute (AHRI)- Mpukunyoni Clinic, Mtubatuba · Africa Health Research Institute (AHRI)- Mtubatuba Clinic, Mtubatuba · Livingstone hospital, Port Elizabeth · Steve Biko Academic Hospital, University of Pretoria, Pretoria · Right to Care NPC, Esizayo Division, Randburg · The Aurum Institute, Rustenburg
Registry updated 2025-09-03
NCT07117370
Assessing the Feasibility of Coach Mpilo for Men With TB and HIV
Trial Treatment · Arizona State University
Desmond Tutu Health Foundation, East London
Registry updated 2025-08-12
NCT07117656
Project Vuselela Feasibility
Trial Treatment · Arizona State University
Anova Health Institute, Johannesburg
Registry updated 2025-08-12

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This page is not medical advice. Talk to your doctor before contacting a trial.

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