Lupus (SLE) trials in United States

In United States 100 Also abroad 354

100 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132
Where
Farmington, Jackson, New York, Oklahoma City
Age
18 years to 75 years
People
35
Run by
Bristol-Myers Squibb
See details and how to joinNCT06875960
No phaseTaking people
Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users
Where
Wilmington
People
442
Run by
AstraZeneca
See details and how to joinNCT06659029
Phase 1/2Taking people
FT839 in Autoimmune Diseases
Where
Fullerton
Age
18 years to 70 years
People
446
Run by
Fate Therapeutics
See details and how to joinNCT07800871
Phase 3Taking people
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
Where
Atlanta, Hackensack, Hershey, Los Angeles, New York, Oklahoma City, San Diego, The Bronx
Age
55 years and over
People
330
Run by
NYU Langone Health
See details and how to joinNCT05799378
No phaseTaking people
Intervention to Improve Communication and Medication Adherence in Lupus
Where
Durham
Age
18 years to 90 years
People
480
Run by
Duke University
See details and how to joinNCT06458075
Phase 1Taking people
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)
Where
Avon Park, Clearwater, Harlingen, Margate, Memphis, Orland Park, Tampa
Age
18 years to 75 years
People
36 worldwide
Run by
AbbVie
See details and how to joinNCT06977724 · EU 2024-519157-10-00
No phaseTaking people
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
Where
Iowa City
Age
18 years to 100 years
People
400
Run by
Terry L. Wahls
See details and how to joinNCT07180537
Phase 4Taking people
PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis
Where
Arvada, Bellaire, Charlotte, Dakota Dunes, Dallas, El Paso, Harlingen, Houston, Jackson, Jacksonville, Kansas City, Kissimmee, Lake Charles, La Mesa, Las Vegas, Lawrenceville, Los Alamitos, Lubbock, Margate, Orchard Park, Orlando, Plano, Rockville, Van Vleck, West Long Branch, Willow Grove
Age
18 years to 75 years
People
150
Run by
Aurinia Pharmaceuticals Inc.
See details and how to joinNCT07611214
Phase 1/2Taking people
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Where
Bethesda
Age
18 years to 120 years
People
78
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT06032923
Phase 3Taking people
A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment
Where
Bellaire, Doral, El Paso, Houston, Kissimmee, Miami, Miami Lakes, San Antonio, Sterling Heights, Sugarland
Age
18 years to 75 years
People
300 worldwide
Run by
Viatris Innovation GmbH
See details and how to joinNCT07201129 · EU 2025-522984-14-00
No phaseTaking people
Systemic Lupus Erythematosus in Gullah Health
Where
Charleston
Age
2 years and over
People
750
Run by
Medical University of South Carolina
See details and how to joinNCT00756769
Phase 1Not yet taking people in United States
BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease
Where
Boston
Age
16 years to 75 years
People
94
Run by
Luminary Therapeutics
See details and how to joinNCT07729995
Phase 1/2Taking people
Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders
Where
Cincinnati, St Louis, Washington D.C.
Age
12 years and over
People
50
Run by
Cartesian Therapeutics
See details and how to joinNCT07089121
No phaseTaking people
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Where
Washington D.C.
Age
5 years to 21 years
People
90
Run by
Children's National Research Institute
See details and how to joinNCT04833465
No phaseTaking people
Wellness & Workforce Solution for Lupus/Lupus Nephritis
Where
Atlanta
Age
18 years and over
People
160
Run by
Morehouse School of Medicine
See details and how to joinNCT06217107
Phase 1Taking people
Phase 1a/b Tolerability of NTR-1011 in Healthy Adults and Adult Patients With SLE and RA
Where
Apple Valley, Beverly Hills, Covina, Monterey Park, Riverside, Temecula, Tujunga
Age
18 years to 75 years
People
24
Run by
Neutrolis
See details and how to joinNCT07237659
Phase 1Taking people
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Where
Boston, Durham
Age
18 years and over
People
125 worldwide
Run by
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
See details and how to joinNCT07115745 · EU 2024-517681-41-00
Phase 2Taking people
Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty
Where
New York
Age
18 years and over
People
80
Run by
NYU Langone Health
See details and how to joinNCT07138898
No phaseTaking people
Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
Where
Baltimore, Charlotte, Columbus, Hixson
Age
18 years and over
People
300 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06527872
Phase 1Enrolling by invitation
A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus
Where
New York
Age
18 years to 65 years
People
6
Run by
Hospital for Special Surgery, New York
See details and how to joinNCT06518668
Phase 1Taking people
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
Where
Aurora, Columbus, Dallas, Las Vegas, Oklahoma City, Scottsdale
Age
18 years to 65 years
People
142 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06576271 · EU 2024-514186-18-00
Phase 1Taking people
US Zamto-cel Autoimmune Diseases
Where
Milwaukee
Age
18 years and over
People
48
Run by
Miltenyi Biomedicine GmbH
See details and how to joinNCT06708845
Phase 1/2Taking people
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Where
Ann Arbor, Atlanta, Chicago, Dallas, Gainesville, Houston, Little Rock, Miami, New Orleans, New York, Plantation, Stony Brook, Summit, Syracuse, Tampa, Tustin, Worcester
Age
18 years to 75 years
People
120 worldwide
Run by
Nkarta, Inc.
See details and how to joinNCT06557265
Phase 1/2Taking people
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE/CLE Participants
Where
Clearwater, Irving, La Palma, Orlando, San Antonio, Syracuse
Age
18 years to 70 years
People
148 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06625671
Phase 1Taking people
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Where
Beverly Hills, Cleveland, Durham, Fullerton, Gainesville, Irvine, Los Angeles, Louisville, Memphis, Miami, Minneapolis, New York, Oklahoma City, Omaha, Philadelphia, San Francisco
Age
12 years to 70 years
People
244 worldwide
Run by
Fate Therapeutics
See details and how to joinNCT06308978