Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
Where
‘Aiea, Albuquerque, Alexandria, Ames, Anaconda, Ankeny, Ann Arbor, Ashland, Aurora, Battle Creek, Bellevue, Bemidji, Bend, Beverly Hills, Billings, Bismarck, Bloomington, Boise, Boone, Boston, Bozeman, Brainerd, Brighton, Burnsville, Caldwell, Canton, Cape Girardeau, Carthage, Cedar Rapids, Centerville, Centralia, Chaska, Chelsea, Chicago, City of Saint Peters, Clackamas, Clinton, Clive, Coeur d'Alene, Colorado Springs, Coon Rapids, Creve Coeur, Danville, Dayton, Decatur, Deer River, DeKalb, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, Eau Claire, Edina, Effingham, Escanaba, Eureka, Fairfax, Falls Church, Fargo, Farmington Hills, Flint, Fort Collins, Fort Dodge, Fosston, Franklin, Fridley, Fruitland, Galesburg, Geneva, Glenview, Goldsboro, Grand Rapids, Grayslake, Great Falls, Greeley, Green Bay, Greenville, Hibbing, Honolulu, Irvine, Jacksonville, Jamestown, Jefferson, Kalamazoo, Kalispell, Kewanee, La Crosse, Lake Forest, Lake Success, Lansing, Lebanon, Little Rock, Livonia, Los Angeles, Loveland, Lynchburg, Macomb, Maplewood, Marshalltown, Marshfield, Mattoon, Maywood, Meridian, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Mukwonago, Muskegon, Nampa, Newark, Newberg, New Richmond, New York, Niles, Normal, Norton Shores, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Omaha, Ontario, Orange, Oregon City, Orlando, Orland Park, Ottawa, Park Rapids, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pontiac, Portland, Post Falls, Princeton, Rapid City, Reed City, Rice Lake, Richmond, Rochester, Saint Johnsbury, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, Sandpoint, Sandstone, Sheboygan, Shiloh, Sioux Falls, Springfield, Stevens Point, St Louis, Stoneham, Sturgeon Bay, Superior, Tappahannock, Traverse City, Troy, Twin Falls, Urbana, Virginia, Waconia, Warrenville, Washington, Waukee, Waukesha, Weston, Willow Grove, Woodbury, Wyoming, Yorkville, Ypsilanti
Age
18 years and over
People
150
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05136196
Phase 1/2Taking people
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
Where
Columbus, Houston, Los Angeles, Louisville, Miami, New York, Orlando, Pittsburgh, Stanford, Tampa, Tucson
Age
18 years and over
People
254 worldwide
Run by
Obsidian Therapeutics, Inc.
See details and how to joinNCT06060613
Phase 1/2Taking people
A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors
Where
Aurora, Boston, Fairfax, Grand Rapids, Los Angeles, Nashville, New York, San Francisco
Age
18 years and over
People
180
Run by
Relay Therapeutics, Inc.
See details and how to joinNCT07584226
Phase 1/2Taking people
A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors
Where
Los Angeles, Scottsdale
Age
18 years to 75 years
People
111
Run by
VM Discovery, Inc.
See details and how to joinNCT07636785
Phase 1Taking people
Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial Metastases
Where
Houston
Age
18 years and over
People
50
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07444606
No phaseTaking people
Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma
Where
Aurora
Age
55 years and over
People
40
Run by
University of Colorado, Denver
See details and how to joinNCT07704918
Phase 3Taking people
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
Where
Allentown, Ann Arbor, Atlanta, Aurora, Baltimore, Boston, Chapel Hill, Chicago, Cleveland, Columbus, Dallas, Duarte, Houston, Jacksonville, La Jolla, Los Angeles, Madison, Miami, Morristown, Nashville, New Haven, New York, Omaha, Orlando, Philadelphia, Phoenix, Pittsburgh, Portland, Richmond, Rochester, Salt Lake City, San Francisco, Scottsdale, Seattle, Sioux Falls, Stanford, Tampa
Age
18 years and over
People
450 worldwide
Run by
Immatics US, Inc.
See details and how to joinNCT06743126 · EU 2024-517062-42-00
Phase 1Taking people
A Study of BI 3810944 in Patients With Advanced Cancer
Where
Charlottesville, Houston, Louisville, Nashville
Age
18 years and over
People
69 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07224425 · EU 2025-522045-21-00
Phase 1/2Taking people
Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
Where
Madison
Age
18 years and over
People
15
Run by
University of Wisconsin, Madison
See details and how to joinNCT07281924
No phaseTaking people
Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma
Where
Bethesda
Age
4 weeks to 99 years
People
3,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00040352
No phaseTaking people
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
Where
Washington D.C.
Age
18 years and over
People
15,000
Run by
Cancer Support Community, Research and Training Institute, Philadelphia
See details and how to joinNCT02333604
Phase 1/2Taking people
Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers
Where
Bethesda
Age
18 years to 72 years
People
124
Run by
National Cancer Institute (NCI)
See details and how to joinNCT02830724
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Anderson, Atlanta, Bethesda, Charleston, Florida City, Houston, Lincoln, Los Angeles, New York, Portland, Puyallup, Spokane, Virginia Beach, Wheat Ridge
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 2Not yet taking people in United States
Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults
Where
Bethesda
Age
3 years to 40 years
People
15
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07891286
Phase 2Taking people
Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
Where
Boston, Los Angeles, New York
Age
18 years to 100 years
People
105
Run by
NYU Langone Health
See details and how to joinNCT05428007
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Grand Rapids, Houston, Lake Success, Los Angeles, Portland, West Valley City
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
No phaseEnrolling by invitation
TruScore Standalone Clinical Study
Where
Boston, Lutherville, Philadelphia, Pleasanton, Tampa, Walnut Creek
Age
22 years and over
People
464
Run by
VeriSkin, Inc.
See details and how to joinNCT06793423
Phase 1/2Taking people
Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
Where
Boston, Nashville, Scottsdale
Age
18 years and over
People
220 worldwide
Run by
Strand Therapeutics Inc.
See details and how to joinNCT07751042
No phaseEnrolling by invitation
Community Based Strategies for Early Detection of Melanoma
Where
Los Angeles
Age
18 years and over
People
200
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT04799106
Phase 2Taking people
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Where
Baltimore, Buffalo, Chicago, Duarte, Houston, Kissimmee, Nashville, New Haven, New York, Rockville, Saint Louis Park, Saint Paul, Seattle, St Louis
Age
18 years and over
People
740 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06172478 · EU 2023-507641-29-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Amarillo, Chattanooga, Dallas, Fairfax, Germantown, Los Angeles, Minneapolis, Nashville, New York, Pearland, Salt Lake City, Skokie, Wenatchee, Westbury, White Plains, Whittier
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 1Taking people
A Phase 1 Study to Evaluate OPB-201 in Recurrent Endometrial and Platinum-resistant Ovarian Cancer.
Where
Atlanta, Detroit, Houston, Minneapolis, San Francisco
Age
18 years and over
People
30
Run by
Outpace Bio, Inc.
See details and how to joinNCT07664735
Phase 1Taking people
Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors
Where
St Louis
Age
18 years and over
People
33
Run by
Washington University School of Medicine
See details and how to joinNCT05629546
No phaseTaking people
Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver
Where
Boston
Age
18 years and over
People
20
Run by
Massachusetts General Hospital
See details and how to joinNCT07364474
Phase 3Taking people
The Cancer of the Pancreas Screening-5 CAPS5)Study
Where
Ann Arbor, Baltimore, Boston, Cleveland, New Haven, New York, Philadelphia, Pittsburgh
Age
18 years and over
People
9,000
Run by
Johns Hopkins University
See details and how to joinNCT02000089