Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
Where
Canton, Cleveland, Detroit, El Paso, Houston, Indianapolis, Los Angeles, Morristown, Nashville, New York, Omaha, Pittsburgh, Rancho Santa Margarita, The Woodlands, Weston
Age
18 years and over
People
240
Run by
Krystal Biotech, Inc.
See details and how to joinNCT05970497
Phase 1/2Taking people
RAPA-201 Therapy of Solid Tumors
Where
Hackensack
Age
18 years and over
People
37
Run by
Rapa Therapeutics LLC
See details and how to joinNCT05144698
No phaseTaking people
In Vivo Liquid Biopsy of Melanoma (Cytophone)
Where
Madison
Age
18 years to 80 years
People
180
Run by
Cytoastra
See details and how to joinNCT06488365
Phase 1/2Taking people
A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
Where
Boston, Denver, Detroit, Fairfax, Fort Myers, Houston, Indianapolis, Los Angeles, Nashville, New Haven, New York, Portland
Age
18 years and over
People
365
Run by
GV20 Therapeutics
See details and how to joinNCT05669430
Phase 1/2Taking people
A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents
Where
Austin, Fairfax, Irving, San Antonio
Age
18 years and over
People
168
Run by
OncoResponse, Inc.
See details and how to joinNCT06090266
Phase 1/2Taking people
Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
Where
Irvine, Pittsburgh
Age
18 years and over
People
160 worldwide
Run by
CJ Bioscience, Inc.
See details and how to joinNCT05877430
Phase 2Taking people
A Study of IBI363 in Subjects with Advanced Solid Malignancies
Where
Dearborn, Fairway, Houston, Ocala, Plantation, San Francisco, Seattle, Troy
Age
18 years and over
People
178
Run by
Innovent Biologics (Suzhou) Co. Ltd.
See details and how to joinNCT06281678
No phaseTaking people
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Where
Albuquerque, Allentown, Ann Arbor, Atlanta, Aventura, Avon, Baltimore, Bay Shore, Bellevue, Bethlehem, Brighton, Buffalo, Burlington, Centerville, Chapel Hill, Chardon, Charleston, Charlottesville, Chicago, Cincinnati, Clackamas, Cleveland, Columbus, Coral Gables, Coral Springs, Creve Coeur, Deerfield Beach, DeKalb, Durham, Easton, Evanston, Fargo, Geneva, Gilbert, Grand Rapids, Greenville, Guilford, Hillsborough, Hollywood, Houston, Indianapolis, Irvine, Jacksonville, Kalamazoo, Kansas City, Lake Forest, Lakeland, Lake Success, Lexington, Little Rock, Livingston, Los Angeles, Madison, Marshfield, Miami, Milwaukee, Mineola, Mobile, Mount Kisco, Murray, New Haven, Newport News, New York, Oklahoma City, Omaha, Orange, Overland Park, Palo Alto, Park Ridge, Pasadena, Philadelphia, Phoenix, Piscataway, Plantation, Portland, Poughkeepsie, Quakertown, Richmond, Roanoke, Rochester, Salt Lake City, San Antonio, San Jose, Savannah, Sayre, Sioux Falls, Sleepy Hollow, Springfield, St Louis, Syracuse, Tampa, Vallejo, Walnut Creek, Warrenville, Washington D.C., Webster, West Chester, Westlake, Weston, Westwood, Winchester
Age
18 years and over
People
2,998 worldwide
Run by
Melanoma and Skin Cancer Trials Limited
See details and how to joinNCT03860883
Phase 1/2Taking people
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
Where
Cleveland, Jacksonville, New York, Rochester, Scottsdale
Age
18 years and over
People
358 worldwide
Run by
GI Innovation, Inc.
See details and how to joinNCT05824975
Phase 1/2Taking people
Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
Where
Boston, Buffalo, Denver, New Haven, Scottsdale, Tampa
Age
18 years and over
People
316
Run by
Simcha IL-18, Inc.
See details and how to joinNCT04787042
No phaseTaking people
DermaSensor Postmarket Surveillance Study
Where
Morehead City, New Smyrna Beach
Age
40 years and over
People
396
Run by
DermaSensor, Inc.
See details and how to joinNCT06666790
Phase 2Taking people
Neoadjuvant Combination Immunotherapy for Stage III Melanoma
Where
Louisville
Age
18 years and over
People
28
Run by
University of Louisville
See details and how to joinNCT03842943
Phase 2Taking people
Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors
Where
Boston, New Haven, Richmond
Age
18 years and over
People
60 worldwide
Run by
IO Biotech
See details and how to joinNCT05280314
Phase 1Taking people
A First-in-human, Phase I, Open-label, Multicenter Study of NM1F(Anti-PVRIG) in Patients With Advanced Solid Tumors
Where
Dallas, Fairfax
Age
18 years and over
People
38
Run by
Hefei TG ImmunoPharma Co., Ltd.
See details and how to joinNCT05746897
No phaseNot yet taking people in United States
Investigating Participation Patterns Among Stage IV Melanoma Patients
Where
San Francisco
Age
18 years and over
People
500
Run by
Power Life Sciences Inc.
See details and how to joinNCT06093594
No phaseTaking people
The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
Where
Elizabethtown
Age
18 years and over
People
800
Run by
VastBiome
See details and how to joinNCT05037825
Phase 1/2Taking people
A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients
Where
Louisville
Age
18 years and over
People
55
Run by
University of Louisville
See details and how to joinNCT01638676
Phase 1Taking people
Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes
Where
Maywood
Age
18 years to 89 years
People
18
Run by
Loyola University
See details and how to joinNCT02870244