Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients
Where
Madison
Age
18 years and over
People
24
Run by
University of Wisconsin, Madison
See details and how to joinNCT06199713
No phaseTaking people
Sample Collection for Ongoing Research and Product Evaluation Study
Where
Austin
Age
18 years and over
People
9,600
Run by
Natera, Inc.
See details and how to joinNCT07318051
Phase 4Taking people
A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3
Where
La Jolla
Age
18 years and over
People
50 worldwide
Run by
Replimune, Inc.
See details and how to joinNCT06887348 · EU 2025-521621-33-00
Phase 1Taking people
ACTengine® IMA203 Combined With mRNA-4203
Where
Boston, Houston, New York, San Francisco
Age
18 years and over
People
15
Run by
Immatics US, Inc.
See details and how to joinNCT06946225
Phase 1Taking people
A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
Where
Canton, Columbus, Dallas, Fairfax, Houston, Los Angeles, Pittsburgh, Tamarac
Age
18 years and over
People
168 worldwide
Run by
OncoNano Medicine, Inc.
See details and how to joinNCT06022029
Phase 3Taking people
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
Where
Atlanta, Chicago, Columbus, Durham, Easton, Hershey, Houston, Iowa City, La Jolla, New Brunswick, New York, Ney York, Orange, Philadelphia, Phoenix, Richmond, Rochester, Salt Lake City, UT, Tampa
Age
18 years and over
People
186 worldwide
Run by
Philogen S.p.A.
See details and how to joinNCT03567889 · EU 2023-507119-36-00
Phase 2Taking people
Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma
Where
Chicago, Los Angeles, New Hyde Park, Tampa
Age
18 years and over
People
32
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT06121180
Phase 1/2Taking people
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma
Where
Iowa City, Salt Lake City
Age
18 years and over
People
33
Run by
University of Utah
See details and how to joinNCT06194929
Phase 1/2Taking people
Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma
Where
Denver, Nashville, Scottsdale
Age
18 years and over
People
36
Run by
Novelwise Pharmaceutical Corporation
See details and how to joinNCT07136181
No phaseTaking people
Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma
Where
Pittsburgh
Age
18 years and over
People
20
Run by
John Kirkwood
See details and how to joinNCT07223411
Phase 1Taking people
Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC
Where
Fairfax
Age
18 years and over
People
76
Run by
LG Chem
See details and how to joinNCT06332755
Early phase 1Taking people
FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma
Where
Charlottesville
Age
18 years and over
People
11
Run by
University of Virginia
See details and how to joinNCT06472661
Phase 2Taking people
Mirdametinib in Patients With Advanced NF1-mutant Melanoma
Where
San Francisco
Age
18 years and over
People
10
Run by
Kevin Kim, MD
See details and how to joinNCT07237100
Phase 2Taking people
Time-of-Day Specified Immunotherapy for Advanced Melanoma, The TIME Trial
Where
Atlanta
Age
18 years and over
People
99
Run by
Emory University
See details and how to joinNCT07155317
No phaseTaking people
Molecular Analysis of Childhood and Adolescent Melanocytic Lesions
Where
Memphis
Age
Up to 18 years
People
500
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT02775643
No phaseTaking people
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma
Where
Louisville
Age
18 years and over
People
30
Run by
Kelly McMasters
See details and how to joinNCT04513028
Phase 1/2Taking people
Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
Where
Beverly Hills, Cleveland, Houston, Pittsburgh, Salt Lake City, Scottsdale
Age
18 years and over
People
108 worldwide
Run by
Strand Therapeutics Inc.
See details and how to joinNCT06249048
No phaseTaking people
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Baltimore, Bethesda, Billings, Birmingham, Boise, Buffalo, Chapel Hill, Charlottesville, Chicago, Cincinnati, Columbus, Dallas, Denver, Duarte, Duluth, Fargo, Greenville, Hartford, Hattiesburg, Hempstead, Houston, Iowa City, Irvine, Jacksonville, Kansas City, La Jolla, Lansing, Little Rock, Littleton, Manhasset, Mayfield Heights, Memphis, Miami, Milwaukee, Mobile, Morgantown, Nashville, Newark, New Brunswick, New Orleans, New York, Norwalk, Omaha, Orange, Philadelphia, Portland, Providence, Salt Lake City, San Francisco, Savannah, Scarborough, Scottsdale, Seattle, Silver Spring, Stanford, Staten Island, St Louis, Tampa, Temple, Towson, Tulsa, Winston-Salem, Worcester
People
50,000 worldwide
Run by
Massive Bio, Inc.
See details and how to joinNCT03452774
Phase 1/2Taking people
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
Where
Boston, Dallas, Fairfax, Gilbert, Pittsburgh
Age
18 years and over
People
30 worldwide
Run by
ImmVira Pharma Co. Ltd
See details and how to joinNCT04370587
Phase 1Taking people
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
Where
Ann Arbor, Cleveland, Fairfax, Houston, Portland
Age
18 years and over
People
67
Run by
Novelty Nobility, Inc.
See details and how to joinNCT06805825
No phaseTaking people
Storage and Research Use of Human Bio-specimens From Melanoma Patients and Clinical Testing for Assignment of Treatment
Where
Nashville
Age
18 years and over
People
3,000
Run by
Vanderbilt-Ingram Cancer Center
See details and how to joinNCT01205815
Phase 1Taking people
Naltrexone and Propranolol Combined With Immunotherapy
Where
New Brunswick
Age
18 years and over
People
12
Run by
Sarah Weiss
See details and how to joinNCT05968690
No phaseTaking people
Excision of Lymph Node Trial (EXCILYNT) (Mel69)
Where
Ann Arbor, Atlanta, Baltimore, Charlottesville, Durham, New York, Philadelphia
Age
18 years and over
People
66
Run by
Craig L Slingluff, Jr
See details and how to joinNCT05839912
No phaseTaking people
Observational Study of Iris Tumors
Where
Portland
Age
18 years and over
People
100
Run by
Oregon Health and Science University
See details and how to joinNCT03809585
Phase 1Taking people
A Study of NX-1607 in Adults With Advanced Malignancies
Where
Aurora, Chapel Hill, Charlottesville, Chicago, Duarte, Houston, Los Angeles, Oklahoma City, San Francisco, Seattle
Age
18 years and over
People
345 worldwide
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT05107674