Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
Where
Cincinnati, Los Angeles, Louisville, Miami, Milwaukee, New York, Orlando, Pittsburgh, Tampa, Westwood
Age
18 years to 70 years
People
53
Run by
Iovance Biotherapeutics, Inc.
See details and how to joinNCT05361174
Phase 1/2Taking people
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain
Where
Columbus
Age
18 years and over
People
24
Run by
Kari Kendra
See details and how to joinNCT05588453
No phaseTaking people
Evaluation of Hypoxia in Primary Melanoma
Where
Pittsburgh
Age
18 years and over
People
50
Run by
Yana Najjar
See details and how to joinNCT06831071
Phase 1/2Taking people
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
Where
Cincinnati, Cleveland, Denver, Durham, Grand Rapids, Houston, Iowa City, Los Angeles, Nashville, New York, Philadelphia, San Francisco
Age
18 years and over
People
336 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT03947385
Phase 1Not yet taking people in United States
Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte Therapy
Where
Duarte
Age
18 years and over
People
8
Run by
City of Hope Medical Center
See details and how to joinNCT07628894
No phaseTaking people
Identification of Metabolic Phenotypes Associated With Melanoma Metastasis
Where
Dallas
Age
18 years and over
People
400
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT06400550
No phaseTaking people
High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies
Where
Houston
Age
19 years and over
People
60
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05053555
Early phase 1Taking people
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
Where
Philadelphia
Age
18 years and over
People
12
Run by
Fox Chase Cancer Center
See details and how to joinNCT05498792
No phaseTaking people
Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
Where
Houston
Age
18 years and over
People
125
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04751396
Phase 1Taking people
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Where
Memphis
Age
Up to 21 years
People
48
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT04897321
Phase 2Taking people
Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases
Where
Palo Alto
Age
18 years and over
People
60
Run by
Stanford University
See details and how to joinNCT06712927
Phase 1/2Taking people
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Where
Atlanta, Austin, Baltimore, Baton Rouge, Boston, Chattanooga, Cincinnati, Dallas, Fairfax, Houston, Maumee, Nashville, New York, Orange, Salt Lake City, San Antonio, Santa Monica, Seattle, Tampa
Age
18 years and over
People
754
Run by
Revolution Medicines, Inc.
See details and how to joinNCT05379985
Phase 1/2Taking people
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
Where
Aurora, Boston, Chicago, Columbus, Houston, Miami, New York, Philadelphia, Pittsburgh, Seattle, Stanford
Age
18 years and over
People
375 worldwide
Run by
Immatics US, Inc.
See details and how to joinNCT03686124
Phase 3Taking people
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Where
Ann Arbor, Aurora, Austin, Baltimore, Boston, Cleveland, Columbus, Dallas, Englewood, Fishersville, Grand Rapids, Houston, Jacksonville, La Jolla, Los Angeles, Madison, Nashville, New York, Oklahoma City, Omaha, Orange, Palo Alto, Philadelphia, Pittsburgh, Riverside, Rochester, San Francisco, Scottsdale, Tampa
Age
18 years and over
People
520 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07015190 · EU 2025-522387-32-00
No phaseTaking people
Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy
Where
Nashville
Age
18 years and over
People
25
Run by
Jessica Mezzanotte Sharpe
See details and how to joinNCT07555210
No phaseTaking people
Quality of Life, Lifestyle, and Psychosocial Factors in Patients With Melanoma
Where
Houston
Age
18 years and over
People
5,000
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04778449
No phaseTaking people
Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
Where
Birmingham, Duarte, Fresno, Fruitdale, Fullerton, Honolulu, Las Vegas, Los Angeles, Mather, Mobile, Monterey, Palo Alto, Salt Lake City, San Francisco
Age
18 years and over
People
2,996
Run by
Stanford University
See details and how to joinNCT05297734
Phase 1/2Taking people
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
Where
Chapel Hill, Chicago, Grand Rapids, Houston, Lake Success, Los Angeles, North Haven, Pittsburgh, San Antonio, San Francisco
Age
18 years and over
People
240 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06413680 · EU 2025-523399-22-00
Phase 1Taking people
A Study of 68Gallium PSMA-PET/CT Scans in People With Bladder Cancer or Skin Cancer
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
20
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05562791
Phase 2/3Taking people
A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
Where
Albuquerque, Aurora, Boston, Denver, Newport Beach, Philadelphia, San Francisco, Stanford, Tampa
Age
18 years and over
People
135
Run by
Linnaeus Therapeutics, Inc.
See details and how to joinNCT06624644
Phase 1Taking people
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
Where
Austin, Buffalo, Dallas, Denver, Fairfax, Houston, Nashville, New Haven, New York, Pittsburgh, San Francisco, Tampa, West Valley City, Westwood, Los Angeles
Age
18 years and over
People
230 worldwide
Run by
Nested Therapeutics, Inc
See details and how to joinNCT06326411
Phase 2Taking people
Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases
Where
Houston
Age
18 years and over
People
35
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05026983
Phase 2Taking people
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Where
Pittsburgh
Age
18 years and over
People
880
Run by
Diwakar Davar
See details and how to joinNCT07223424
No phaseTaking people
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04693377
Early phase 1Taking people
RP1 in Primary Melanoma to Reduce the Risk of Sentinel Lymph Node Metastasis
Where
Pittsburgh
Age
18 years and over
People
25
Run by
Yana Najjar
See details and how to joinNCT06216938